Development of targeted degradation of Nuclear Receptor Binding SET Domain Protein 2 (NSD2) by Proteolysis-targeting chimera (PROTAC) for the study of its role in SARS-CoV-2 infections

The recent outbreak of the SARS-CoV-2 associated coronavirus disease, COVID-19, had been declared a global pandemic by the World Health Organization. There is still only a minimal understanding of the virus and an absence of effective targeted therapy for its treatment. Epigenetic regulations in cells control the expression of genes without modifications to the genetic […]

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Developing a Remote Search Engine for Histopathology Scans

The wide-spread adoption of digital pathology has opened new horizons for histopathology. Artificial intelligence (AI) algorithms are able to operate on digitized slides to assist pathologists with different tasks. Whereas AI involving classification and segmentation methods have obvious benefits for image analysis, image search represents a fundamental shift in computational pathology. Image-based search for digitized […]

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COVID-19 and the Future of Ontario’s Agricultural Workforce

The Canadian agricultural sector has been particularly effected by the outbreak of the COVID-19 pandemic. Due to shortages in agricultural labour, the sector relies on the annual arrival of migrant workers, which in 2020 was disrupted due to the travel restrictions and quarantine orders enacted to fight the spread of this virus. As a result, […]

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SOTI SNAP Widget SDK Front-end and User Interface Toolkit

SOTI has developed a software product called SOTI SNAP that allows anyone to create an app with no programming or technical knowledge. SOTI SNAP allows users to create apps by dragging and dropping widgets onto a canvas and connecting them together to create an app. With SOTI SNAP apps can be created in minutes and […]

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Preparation of Sentinel Wraps for Detection of Pathogens in Food Packages

The goal of this project is to develop and integrate the required technology to create food wrapping materials that can tell any untrained consumer if the food is safe to eat, without the need to use sophisticated equipment. This will be achieved by incorporating a barcode-type biosensor on an antifouling food wrap. The biosensor is […]

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SOTI SNAP Widget SDK Back-end Deployment

SOTI has developed a software product called SOTI SNAP that allows anyone to create an app with no programming or technical knowledge. SOTI SNAP allows users to create apps by dragging and dropping widgets onto a canvas and connecting them together to create an app. With SOTI SNAP apps can be created in minutes and […]

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Exploring and Improving Self-supervised Methods for Large-scale Video Recognition

With the advancement of modern technology, especially the increase in network speed, videos are taking more and more important places among media types. With vast potential applications, video recognition has received great attention. However, video recognition is a non-trivial task: a lot of training data are needed for complicated neural networks, but annotated data are […]

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Development of Optical Clearing Materials Towards Oral Lesion Pathology Screening with Optical Coherence Tomography

The early identification of oral cancers will help to reduce serious complications and death associated with these diseases. Currently, identification of cancerous tissues relies significantly on visual identification during oral exams before more accurate further testing is performed. The use of optical coherence tomography (OCT) has allowed for more accurate initial identification of cancerous tissues, […]

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Generating a COVID-19 vaccine using ministring DNA and virus-like particles

The COVID-19 pandemic is a global health crisis on an unprecedented scale, with over 1 million confirmed cases, spread over 200 countries. With the world at a virtual standstill, and no existing treatments, there is an enormous need for novel therapeutics and vaccines to combat COVID-19. Our group is working on a DNA vaccine strategy […]

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COVID-19 Monitor: a rolling public opinion study on the dynamics of the pandemic

This project will undertake a year-long rolling study of public opinion across eight countries—Canada, the United States, the United Kingdom, Australia, New Zealand, France, Germany and Brazil. It will measure the health, social, and economic impacts of COVID-19 throughout the duration of the pandemic and during its immediate aftermath. The study will be comprised of […]

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Machine learning and the COVID Black Box: Safe monitoring of COVID-19 ICU beds, assessment centres, and surgeries

The project aims to optimize healthcare provider and patient safety and monitor PPE use, to optimize resource utilization during the COVID-19 pandemic. Assessment of surgical data from an operating room is a complex process that may require significant resources such as expert input and advanced technology. Automation brings a considerable opportunity to greatly reducing these […]

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