Tissue Microstructure of Surgical Specimens depicted with Optical Coherence Tomography

Perimeter Medical Imaging (PMI) has developed an investigational imaging device to aid in achieving clear margins during surgical oncology procedures. This project will employ PMI’s device to image multiple types of human tissues, which have been previously removed during elective or medical procedures. This study will correlate the images obtained using PMI’s device with the […]

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Characterization of Plant Growth Promotion effects through the application of Bacteria Pseudomonas spp. strains. KGS-2 and KGS-8 for enhanced Commercial Value of field crops

This project will provide characterization of two strains of Pseudomonas spp. for the use of plant growth promotion. The project will accomplish this through direct field trials in order to show the benefits of these strains when inoculated on canola. We wish to explore/demonstrate other key features of these organisms such as bioremediation hydrocarbons and […]

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Novel Cell-surface Engineering Methods to Increase Immune-tolerance of Allogenic Cell Transplantation

Blood transfusion is required for surgery, for the treatment of traumatic accidents and for patients with disorders that require lifelong transfusion therapy. However, when patients receive “mismatched” blood transfusion, their immune system will attack and destroy red blood cells with surface sugars and proteins that differ from their own. This results in massive immune responses […]

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Développement d’un procédé novateur de traitement des lixiviats hautement chargés issus du procédé de compostage

Ce projet de recherche vise à développer un procédé innovant pour répondre à une problématique de traitement des eaux usées à laquelle font face les centres de traitement en Amérique du nord. Les variations climatiques saisonnières limitent les capacités de traitement du procédé conventionnel de lagunage en termes de volume de traitement et de réduction […]

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Multi-biomarker test for the management of acute cardiac transplant rejection

The high incidence of acute organ rejection following heart transplantation poses major problems for patients, clinicians, and the healthcare system. A major clinical challenge in this regard arises from the difficulty of accurately and efficiently diagnosing when organ rejection occurs. In Canada, the current approach to diagnosing acute rejection requires taking small pieces of the […]

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Multi-biomarker test for the management of acute cardiac transplant rejection – Year two

The high incidence of acute organ rejection following heart transplantation poses major problems for patients, clinicians, and the healthcare system. A major clinical challenge in this regard arises from the difficulty of accurately and efficiently diagnosing when organ rejection occurs. In Canada, the current approach to diagnosing acute rejection requires taking small pieces of the […]

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Developing a Lipid-Based System for Co-delivery of a Vaccine and Adjuvants

University of British Columbia and Amgen British Columbia (ABC) will collaborate to develop a safe and efficient lipid-based vaccine delivery system that can be used in laboratory animals to enhance the production of specific antibodies against difficult targets. These antibodies can be further screened and characterized for treating various diseases in humans.

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Biomolecular Quantitation and Structure Analysis to Accelerate Development of New Vaccines

Manufacturing of consistently high quality products is the commitment of the pharmaceutical industry. To achieve this, new products must be thoroughly tested and the results meet government-approved product specifications. Improving existing and adopting improved analytical technologies for product testing ensure the production of safe and effective products. This is particularly critical for the manufacturing of […]

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Leveraging genomic information to better understand the biological effect of major genes on reproduction and health traits in dairy cattle

The main objective of the study is to increase the discovery of important reproduction and health genetic variants in dairy cattle. This could help improve reproduction and health of dairy herds through genomic selection or editing of the genome. In order to find the causative variants affecting reproduction and health traits, a review of the […]

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Oncolytic HSV-1 (oHSV-1) for Treatment of Urologic Cancer

This project is to use genetic engineered “cold-sore” virus to treat prostate cancer. The virus is engineered to reduce its toxicity to normal tissues but can specifically attack and kill tumour cells. Meanwhile, the virus releases a group of anti-tumour immune stimulating factors to activate immune system to eliminate prostate tumour. This project will use […]

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Isolation of marine microalgae for sustainable production of squalene

Marine microalgae are currently used as a source of high value polyunsaturated lipids such as DHA and EPA. The focus of this research is to isolate a strain of marine microalgae that can produce commercially viable amounts of squalene. Squalene is a high value hydrocarbon that is predominately extracted from the liver of deep sea […]

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Monodisperse PhytoSpherix Nanoparticles Modified for Key Applications in Personal Care, Food and Nutraceuticals – Year two

Our previous work has shown the promise of monodisperse phytoglycogen for many applications. However, these experiments only scratch the surface of potential uses since the chemistry of the particles (as extracted) is fixed. Nanoparticles offer very high surface areas, and glucose units are easily modifiable, thus there exist a multitude of ways to chemically modify […]

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