Boronate Ester-Based Strategies for Controlled Therapeutic Protein Release

The proposed project is focused on developing an improved therapeutic protein for the treatment of osteoarthritis (OA). More than 10% of the world population (primarily those over the age of 50) are impacted by OA, an inflammatory joint disease that affects all the joint tissues due to cartilage loss and to date lacks curative treatment. […]

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Personalized Virtual Patient Simulation for Decision Support in Intensive Care Units

Challenges in today’s Intensive Care Units (ICUs) involve the management of patients’ life critical physiological systems. ICUs must constantly make fast and personalized treatment decisions (e.g. ventilation settings, fluid management, and vasopressors) that require constant monitoring, patient specific response predictions, and real time decision support. This project explores the use of Cellular Discrete Event System […]

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L2M-Blue Beauty Innovation: Sustainable Seaweed Bioactives for Cosmetics and Skincare

Title “Blue Beauty Innovation: Sustainable Seaweed Bioactives for Cosmetics and Skincare” This project explores the potential of using natural compounds extracted from sugar kelp (Saccharina latissima), a seaweed that grows abundantly in Atlantic Canada, as safe and effective ingredients for skincare and cosmetic products. Around the world, consumers and companies are looking for cleaner, more […]

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Functional genomic analysis of patient-derived pre-clinical models of renal cancers to identify novel therapeutic targets

Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Its metastatic form (mRCC) remains incurable and resistant to chemotherapy and radiation. Current treatments targeting the tumor microenvironment offer limited benefit, highlighting the need for new strategies based on disease biology. ccRCC is difficult to target due to its cellular heterogeneity […]

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Deciphering the role of plant mitochondrial alternative oxidase (mtAOX) isoforms by protein carbonylation profiling

Plant cells naturally express enzymes that remove the reactive oxygen species (ROS) or prevent their production to a detrimental level under stress conditions. One such protective enzyme is the alternative oxidase enzyme (AOX) that is unique to plants among all other eukaryotes. There exist five AOX enzyme isoforms, AOX1a, AOX1b, AOX1c, AOX1d and AOX2, in […]

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Étude des altérations de la structure et du fonctionnement cérébral consécutives à un traumatisme crânien léger chez le jeune enfant.

Le traumatisme crânio-cérébral léger (TCCL) constitue un enjeu majeur de santé publique : les enfants de 0–6 ans sont particulièrement vulnérables, alors que la majorité des travaux se concentre sur les plus âgés, suggérant que les TCCL induisent des altérations cérébrales persistantes au-delà de 3 mois post-blessure. La thèse de V.Chouquet étudie ces altérations cérébrales […]

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L2M- TATOM

We will validate TATOM (Tumor-on-a-chip assembly to observe metastasis), a miniature human-on-a-chip platform mimicking cancer metastasis for drug testing. Through customer discovery and market analysis by initially interviewing critical parties in the sector. Through these interviews, we will assess commercial viability, identify user needs, and finally refine the business model to accelerate translation to clinic […]

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Intelligence Artificielle multimodale pour la classification précise, le sexage et l’évaluation de l’hybridation des poissons afin de retracer leur lignée parentale, soutenir leur préservation et contribuer à la taxonomie moderne

Le projet de recherche proposé vise à développer un système basé sur l’Intelligence Artificielle multimodale pour analyser à la fois les images morphologiques et les données génétiques de poissons appartenant aux espèces Diaphanus et Heteroclitus. L’objectif est de permettre l’identification automatique des espèces, de déterminer le sexe des individus et d’évaluer le degré d’hybridation afin […]

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Bacterial genome integrity under growth-limiting conditions

Many bacteria live in environments where food and energy are scare. When this happens, they may start copying their DNA and then run out of resources mid-way, puuting their genetic material at risk of damage. This project will study how Escherichia coli protects its DNA under sudden nutrient starvation. We will track whether cells finish […]

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L2M- Biorenewable and Biodegradable Cellulose-based Gloves

This project focuses on validating the market potential of a new kind of sustainable, fully biodegradable glove made from renewable cellulose—designed to replace the billions of plastic-based disposable gloves used each year in Canada. Over four months, we will manually produce prototype gloves, share them with healthcare, laboratory, and food-service users, and collect real-world feedback […]

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rom Quebec Waters to Innovation: Bacterial Adhesins as a Source of Antifouling Solutions

This project studies how aquatic bacteria isolated from Quebec’s aquatic environments attach to underwater surfaces and form biofilms, the first step in biofouling. Biofouling is a major challenge for the maritime industry, as it increases energy use, damages equipment, and helps invasive species spread. Among the bacteria responsible for the first stages of biofouling, species […]

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