Linking microbiome to eco-industrial function: the in silico and metagenomic exploration of microbial dark matter and taxonomic blind spots

“A large majority of microbes cannot be cultured. Recently, microbiome sequencing has begun to identify the genetic potential of these lineages, often referred to as microbial “dark matter”. By integrating my taxonomic profiling methods with function profiling developed by the academic supervisor, I aim to develop and apply a comprehensive pipeline for microbial dark matter […]

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Linking microbiome to eco-industrial function: the in silico and metagenomic exploration of microbial dark matter and taxonomic blind spots – Year two

The collection of bacteria and archaea in an ecosystem is termed the microbiome. This microbiome is critically important to the structure and function of essentially any ecosystem, providing many ecosystem services, such as growth promotion, nutrient turnover, and impacts on organismal health. The vast majority of these organisms, however, are unknown to science for a […]

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Implementing a novel infectious disease diagnosis assay to a microfluidic device

Infectious diseases ranging from avian influenza to Ebola virus infection are among the most serious health emergencies in Canada and globally. Current diagnosis methods such as cell culture, ELISA and PCR suffer from inaccuracy, high-cost and lengthy procedures. Therefore, there has been a growing trend to develop new point-of-care diagnostic tools and microfluidic devices are […]

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Mise au point d’une méthode rapide (ICC-qRT-PCR) pour l’analysee de l’efficacité antivirale de nouveaux désinfectants

Les infections nosocomiales sont des infections contractées dans les établissements de santé et représentent un problème de santé publique majeur. Dans les établissements de santé québécois, on évalue qu’entre 80 000 et 90 000 personnes sont atteintes d’une infection nosocomiale, ce qui correspond à 10% des admissions. Dans ce contexte, il est alors urgent de […]

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Scale-up of Bioaugmentation Cultures and Development of Delivery Strategies and Monitoring Tools for Anaerobic Benzene and Alkylbenzene Bioremediation

The overall objective of this project is to scale up and demonstrate the utility of novel bioaugmentation cultures for BTEX compounds, and associated diagnostic tools to properly deploy the technology. The intern will lead the project team to develop gene-based biomarker tools applicable to the bioaugmentation cultures and apply these tools to samples submitted from […]

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Développement et optimisation de procédés de production de 2 cutinases pour applications industrielles

Le but général est de favoriser la commercialisation de deux enzymes de type cutinase en développant des procédés de production/purification prometteurs et d’intérêt industriel. Les cutinases sont des enzymes intéressantes pour l’hydrolyse de divers corps gras et de certains plastiques, ainsi que pour la modification de surfaces. Pour chacune des cutinases, cinq (5) objectifs spécifiques […]

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Defining cell therapies using CNS tissue sources in living Parkinson’s Disease patients

There is a critical need for new therapies for Parkinson’s Disease (PD), a devastating neurodegenerative disease. Current therapies for PD treat disease symptoms, but do not provide a cure. The ability to generate patient brain-derived cells may rapidly advance development of personalized therapies for PD and other incurable neurological disorders. This study will use brain […]

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A rapid screening tool for multiple tick pathogens/Maritime tick bank

Ticks contain many different disease-causing bacteria and viruses, including the bacteria that causes Lyme disease. Multiple infections with these other pathogens in addition to Borrelia cause more severe illness. For many of these pathogens there are no or limited diagnostic tools available to detect the pathogen. This project includes production of a new product, “a […]

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Site-specific Immunomodulators for COPD

Qu Biologics is a clinical-stage biopharmaceutical company developing and evaluating an innovative immunotherapeutic approach to treating disease rooted in immune pathology/dysfunction. Qu’s proprietary technology platform, site-specific immunomodulators (SSI), act to stimulate the body’s own immune system to reverse the chronic inflammation underlying many conditions including cancer and immune-mediated diseases. For lung diseases, Qu’s platform SSI, […]

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Biomolecular Structure Analysis to Accelerate Develoment of New Vaccines and Monoclonal Antibodies

Manufacturing of consistently high quality products is the commitment of the pharmaceutical industry. To achieve this, new products must be thoroughly tested and the results meet government-approved product specifications. Improving existing and adopting improved analytical technologies for product testing ensure the production of safe and effective products. This is particularly critical for the manufacturing of […]

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