MRI-microscopy co-registration and 3D reconstruction of human cortex and amygdala for multi-modal assessment of epileptogenicity in drug-resistant epilepsy

Through combining information from MRI and microscopy, this research aims to propose advanced computational methods for the registration, reconstruction, and analysis of brain images. To improve the accuracy and resolution of the combined brain scans, a key component of this effort is the application of statistical techniques to create correlations between the various imaging modalities. […]

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Affordable Housing Analysis

This project is a historical analysis of Federal/Provincial affordable housing agreements signed from 2000 to 2011 and whether the housing stock continued to be rented at affordable rates after the agreements expired. Federal/provincial housing agreements during the 2000-2011 period primarily consisted of capital grants to the private sector (for profit and non-profit) to develop affordable […]

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Deep Learning-Enabled 3D Fluorescence Imaging for Cancer Surgery

The Princess Margaret Cancer Centre, part of the University Health Network (UHN), is Canada’s largest cancer hospital and one of the top 5 cancer research centres in the world. This internship will take place in the Guided Therapeutics (GTx) lab, part of the cancer centre’s research institutes. The GTx lab is developing novel devices, algorithms, […]

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L2M – Development of a data-driven coaching and rehabilitation app for running based athletes

Lab2Market is a program designed to help graduate students with the innovation and entrepreneurial skills required to develop their research projects into start-ups. This project aims to develop a minimum viable product and develop a business/product roadmap for a single camera markerless motion capture system designed to accurately track human movement’s during a variety of […]

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L2M – Strategic Development of ADAMTS13 as Novel Thrombolytic for Ischemic Stroke

We are developing a new treatment for ischemic stroke using a modified version of a natural anticoagulant called ADAMTS13. Existing stroke therapies are limited by a short treatment window and can carry serious risks. This new approach aims to safely extend the time patients can receive treatment, increasing access, especially for those in rural or […]

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L2M- ZAP-010 – A natural, effective appetite suppressant

This project is focused on developing a novel, plant-based appetite suppressant called ZAP-010. Originally synthesized for agricultural use, ZAP-010 is a phytohormone that we have shown to reduce food intake and promote sustained weight loss in rodent models. Over 60% of Canadian adults are classified as overweight or obese and current treatment options, such as […]

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Metabolomics & Cancer Biomarkers

Renal cell carcinoma (RCC) is a common and aggressive form of kidney cancer, often diagnosed at advanced stages due to the lack of early symptoms. This project aims to improve RCC diagnosis by identifying metabolic biomarkers through a multiomics approach, integrating metabolomics and transcriptomics data. Using advanced mass spectrometry (LC-MS) and computational tools like CAT […]

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Design Principles of Biological Networks

This project aims to uncover the design principles of biological networks, such as blood vessels in the kidney and brain, by developing automated tools to analyze high-resolution 3D images of human embryo vasculature. Using advanced imaging techniques and deep learning, the research will create efficient methods to study how these networks efficiently transport nutrients and […]

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Non-invasive assessment of early molecular response and detection of minimal residual disease in diffuse large B-cell lymphoma (DLBCL) using cell-free methylomes

Research at the Lymphoma Lab is driven by the observation that the outcomes of lymphoma are extremely variable with some patients seem cured or enjoying long remissions while others experience relapse. Treatments that directly target the underlying therapeutic vulnerabilities of a patient’s lymphoma remain unavailable [1]. Lymphoma Lab wants to change this. A comprehensive understanding […]

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L2M – Combined Gamma Probe and Ultrasound Imaging System for Cancer Surgery

Breast cancer is the leading cause of cancer among women, with over 30,000 new cases diagnosed across Canada every year. Most patients undergo breast conserving surgery to remove the tumour, but in over 20% of cases, some of the cancerous tissue is missed, requiring the patient to have a second surgery. We are currently developing […]

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L2M – RevoStep: Advancing Mobility Innovation

The intern is developing a new patent-pending mobility device (class 1 medical device) called the RevoStep, which utilizes an innovative peg-leg mechanism with integrated springs to the user’s injured leg that drastically reduces the load and redirects it away from the injured knee. This innovative product offers a more convenient and flexible recovery alternative to […]

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