Optimization of the immune response against transferrin receptor based vaccines

The bacterial transferrin receptor is considered to be a potentially efficacious candidate vaccine antigen against pathogens important in human disease and in animal husbandry. Previous data suggests that transferrin receptor-based antigens can elicit protection from both invasive disease and potentially from asymptomatic colonization. One major consideration when developing vaccines is the choice of adjuvant, a […]

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Optimization of Long Term Quantitative Market Predictions

Financial markets today are monitored and controlled by machine learning algorithms. The primary objective of this project is to further develop the algorithm for financial market analysis and prediction that the partner possesses at the moment. The algorithm currently demonstrates high accuracy, subject to certain constraints, among which: a small time interval between a prediction […]

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Self-powered microchips for rapid diagnosis and severity determination of urinary tract infections

Children presenting a fever without known sources are usually checked for bacterial urinary tract infection (UTI) which, in its more complicated forms, can result in permanent kidney damage. The gold standard conventional tests to diagnose complicated urinary tract infections are urine culture and kidney imaging with a radioactive tracer. However, these tests are lengthy (urine […]

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Analyse de solutions logistiques innovantes pour l’approvisionnement en biomasse forestière d’une bioraffinerie implantée sur le territoire de la ville de La Tuque

BioÉnergie La Tuque, qui est une OBNL partenaire, cherche à mettre en place les conditions nécessaires à l’implantation d’une bioraffinerie sur le territoire de la ville de La Tuque permettant de convertir 1 200 000 TM de biomasse forestière résiduelle verte en 200 millions de litres de biodiesel, ou diesel renouvelable et ce, à un […]

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Analyse de solutions logistiques innovantes pour l’approvisionnement en biomasse forestière d’une bioraffinerie implantée sur le territoire de la ville de La Tuque – Year two

BioÉnergie La Tuque, qui est une OBNL partenaire, cherche à mettre en place les conditions nécessaires à l’implantation d’une bioraffinerie sur le territoire de la ville de La Tuque permettant de convertir 1 200 000 TM de biomasse forestière résiduelle verte en 200 millions de litres de biodiesel, ou diesel renouvelable et ce, à un […]

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Development of a model for computational sea ice monitoring

The proposed research project focuses on the development of a novel model for the computation of sea ice parameters in near real- time relying on satellite data. The interdisciplinary team will investigate solutions for high performance computing to monitor sea ice and calculate ice parameters with the high spatial resolution. This project includes R&D activities […]

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Efficacy of a novel anti-IL-1B receptor modulator in reducing preterm birth impact on neurovascular health

Preterm neonates ill-adapted to the extra uterine environment are prone to increased inflammation in multiple organs and the proinflammatory interleukine IL-1b has been closely implicated in brain injury associated with preterm birth (PTB). One major adverse neuronal outcome for PTB survivors is the greater propensity to develop ischemic brain lesions long after birth. Here, we […]

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Efficacy of a novel anti-IL-1B receptor modulator in reducing preterm birth impact on neurovascular health – Year two

Preterm neonates ill-adapted to the extra uterine environment are prone to increased inflammation in multiple organs and the proinflammatory interleukine IL-1b has been closely implicated in brain injury associated with preterm birth (PTB). Notably, PTB survivors have a greater propensity to develop ischemic brain lesions long after birth. Here, we hypothesize that the neural vasculature […]

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Development of miniature fluorescence microscope with optogenetically synchronized patterned illumination

Myriad of complex interactions from molecular to system level underlie the functioning of the brain, and their thorough understanding is crucial for ultimate experimental goals of neuroscience. Recent breakthroughs in optogenetics allow controling the activity of small groups and even single neurons while recording their responses with minimal effect on natural biological processes. Currently though, […]

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Development of miniature fluorescence microscope with optogenetically synchronized patterned illumination – Year two

We propose development of miniature fluorescent microscope with flexible spatiotemporal photostimulation patterns of ensembles of neurons in freely behaving animals.For precision and targeted photostimulation of light-activated proteins (opsins), the light beam from high power incoherent light source will be shaped by user-controlled digital micromirror device (DMD). The light patterns formed by DMD will be sent […]

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Determination of active surface area, gas permeability, and mass transport resistance in fuel cell catalyst layers

Gas transport in polymer electrolyte membrane fuel cells is of increasing interest since low gas crossover is desired in the membrane, however high gas transport is desired in the catalyst layer where ionomer is present (and is typically similar in chemical structure to the membrane). This project will investigate the permeability of oxygen, nitrogen, and […]

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