Intraoperative optical characterization of brain tumor tissues

The goal of neurosurgery are two folds, 1) to achieve maximal resection of the target lesions, but simultaneously 2) minimize damage to adjacent healthy brain tissues. Currently surgeons rely on preoperative images such as Magnetic Resonance Imaging to define tumor boundaries. However, the accuracy of such images decreases intraoperatively due to brain shift. For these […]

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Development of negamycin, a novel class of antibiotic for Gram-negative bacterial infections

Antimicrobial resistance threatens effective prevention and treatment of microbial infections. Over two million hospitalized patients acquire infection from antimicrobial resistant microbes resulting in more than 23,000 deaths in North America. Therefore, development of a novel class of antimicrobials is in urgent need. The goal of our research project is to develop a novel antibiotic for […]

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Developing Energy-Efficient HVAC-R Systems for Smart Buildings

AYO Smart Home Ltd. is pursuing the development of integrated energy management technologies for smart buildings. Various approaches such as heat recovery, solar energy, energy storage, and passive cooling are being investigated by the AYO Smart Home Ltd. company. Novel technologies for Heating, Ventilating, Air-Conditioning, and Refrigeration (HVAC-R) are also considered as a crucial part […]

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Dopamine Receptor Imaging in Dementia Using Hybrid PET/MRI

Although life expectancy is increasingly associated with the treatment of heart disease and cancer, there has been virtually no improvement in life expectancy for patients with dementia. Dementia has a devastating impact to the patient, family members and society because patients become dependent on family caregivers, who are then less productive in other aspects of […]

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Analysis, development and implementation of virtual and face-to-face mechanisms and tools to stimulate coordination, exchange and collaboration between members of a community of entrepreneurs

This project seeks to perform an analysis about the dynamics of interactions between members of an entrepreneurship community. Entrepreneur’s behaviors will be compared with the literature on knowledge transfer and concepts about entrepreneur’s thinking. Using data collected within the entrepreneur community and concepts, the intern will define the parameters needed for the development of effective […]

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Intracellular growth of Mycobacterium tuberculosis: prospects for drug discovery

The success of Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), lies in its ability to primarily infect, reside, and multiply in the lungs of patients. Mtb infects white blood cells termed alveolar macrophages and hides from the host immune response as well as from many antibiotics used for treatment, creating additional challenges for […]

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Rapid Health Impact Assessment On Introducing Permanent High Occupancy Vehicle Lanes and High Occupancy Tolls Lanes In the Greater Toronto Area

The WHO defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”. The holistic nature of this definition provides the basis for an all-encompassing evaluation of health, which is the guiding principle behind health impact assessment (HIA). An emerging area of public concern in […]

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Impact de la navigation en milieu lacustre sur la qualité de l’eau et le relargage de polluants

L’augmentation des sports nautiques utilisant des embarcations à moteurs est une préoccupation pour les citoyens, associations, municipalités soucieux de l’impact écologique sur les lacs. Il est difficile de trouver des solutions environnementales et durables satisfaisantes en termes de réglementation. Ce projet de recherche est donc défini afin de fournir un cadre scientifique dont le but […]

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Assessment of melanotransferrin as an Alzheimer’s disease biomarker

Biomarkers that can reliably detect Alzheimer’s Disease (AD) are essential for disease monitoring and development of drug therapy. We have shown that a protein, melanotransferrin (MTf), is elevated in the blood of humans with AD but is nearly undetectable in age-matched healthy controls. We will further validate MTf as a biomarker in mouse models of […]

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InvDeveloping a precision inspection technique of transmission line infrastructure using Unmanned Aerial Vehicle

UAV-based data analytics is an emerging technology with a high degree potential to replace or compensate traditional airborne-based mapping for infrastructure risk analysis. However, current development does still not reach to its maturity, allowing its immediate application to practical operations due to the complexity of flying dynamic and object understanding. This project aims to investigate […]

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