Extensive research has been conducted for the computational analysis of mass spectrometry based proteomics data, however most of the traditional computational approaches take the assumption that the acquired spectra are generated from the fragmentation of a single precursor and the peptide is simply a linear sequence of amino acid residues. This ubiquitous assumption is impeding […]

Customized image sensors will be designed by EnviroSen specifically for advanced microscopes used in biomedical imaging. The goal is to develop image sensors with improved efficiency, image resolution and speed compared to existing technologies for novel microscopes for fluorescence lifetime imaging. The McMaster Biophotonics group has recently developed a novel microscope that is capable of […]

Detecting subtle chemical and physical changes occurring at the early stages of chronic disease and many other infectious diseases caused by harmful bacteria is still a challenge, as ultra-sensitive sensors with large signal-to-noise-ratio are required to detect them. We recently explored new ways to enhance the sensitivity of magnetic nano-sensors and theoretically demonstrated that under […]

Detecting subtle chemical and physical changes occurring at the early stages of chronic disease and many other infectious diseases caused by harmful bacteria is still a challenge, as ultra-sensitive sensors with large signal-to-noise-ratio are required to detect them. We recently explored new ways to enhance the sensitivity of magnetic nano-sensors and theoretically demonstrated that under […]

Improved application of hemp and flax fibres in advanced materials will promote Manitoban agriculture and associated industrial production in the emerging bioeconomy. The proposed research will provide, via high resolution chemical mapping, the fundamental science platform required for the rational design of advanced, sustainable biocomposite materials, combining appropriate fibre-matrix complexes de novo. It will augment […]

Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently […]

The continuum of HIV care is highly complex. It includes prevention, testing, patient care, treatment, and support services. This project will help Providence Health Care utilise its limited resources to provide the best treatment and care for people living with HIV in Vancouver. Care for HIV patients includes antiretroviral therapy, treatment of co-morbidities, monitoring clinical […]

The complement system is an essential component of innate immunity, but also causes self-damage when the system is aberrantly activated or self-protective capacity is exceeded. There are many conditions where failure to protect against self-damage from the complement system has been implicated in the pathology, including Alzheimer’s disease, Parkinson’s disease, Lou Gehrig’s disease, paroxysmal nocturnal […]

User intention prediction of event data, collected during the business process, has become an important topic in Web Analysis and Business Intelligence. Commercial organizations have realized its importance for providing cost-effective opportunities to improve their decision-making in digital marketing strategies. We aim to develop and implement a statistical prediction model to make the prediction of […]

Governments around the globe are trying new approaches to solving complex social problems. They are increasingly moving away from the direct provision of social services towards more collaborative partnerships with the private sector. Pay-for-success, also known as pay-for-performance or Social Impact Bonds, is a method for engaging the private sector that has been gaining attention […]

Avec un marché qui devrait dépasser les 200 milliards de $ US en 2020, le domaine des produits cosmétiques et un moteur économique important à l’échelle mondiale, mais également canadien. Cette activité requiert de la part des entreprises un investissement important en recherche et développement afin de rester compétitive face à la concurrence. Cette proposition […]

Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic […]