Synthèse d’inhibiteurs ? en structure d’épingle à cheveux du point de contrôle PD-1 / PD-L1

Il a été démontré que les tumeurs exploitent certains mécanismes liés aux récepteurs immunitaires (point de contrôle) pour échapper à la réponse immunitaire. La mise sur le marché d’anticorps monoclonaux (mAbs) approuvés par la FDA, pembrolizumab et nivolumab en tant qu’inhibiteurs du récepteur immunitaire programmed death-1 (PD-1), et du durvalumab et de l’avelumab qui ciblent […]

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Microstructural analysis of through-thickness compaction in dry fibrous reinforcements

The project aims to analyze the through-thickness compaction of dry fibrous reinforcements at the mesoscopic scale. Predicting how fiber tows deform during the compression of woven fabrics is important in resin injection processes because textile deformation plays an important role on permeability. Fiber orientation governs also mechanical performance. Hence, compaction represents a key issue that […]

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Microscope/Macrocosm: Early Modern Technology, Visualization and Nature

Undertaking this project through Mitacs Globalink will provide me with a rare opportunity for extended time with the expert scholars, specialized research institutions and archival material in England that will allow me to greatly enhance the research component of my dissertation while also forming important links to a community of international researchers. I will be […]

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Nanoscale toolset for formatting and visualizing single molecules: validating applications and miniaturized flow cells

The “CLiC” microscopy technique was invented and developed by Prof. Sabrina Leslie and her lab at McGill. It is ideal for formatting and visualizing single molecules, like DNA and proteins, with advantages that overcome the limitations of other single-molecule techniques. Due to the increasing interest in the technique from academic and industrial researchers, Prof. Leslie […]

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Fatty liver assessment with Attenuation Coefficient Estimation (ACE)

One in every five people will develop liver disease in their lifetime. Few people think about liver disease until the disease has progressed and has permanently damaged the liver. Fatty liver disease falls into this category with obesity as the most common cause. Given more than 50% of Canadians are overweight and 75% of obese […]

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Surveillance and big data on the home front: voice-controlled technology in domestic space

The central research question of this project is: how does the normalization of voice-controlled technology in domestic space change the meanings attached to home? The project will focus specifically on Amazon’s Alexa-enabled smart speakers by analyzing how online discourse surrounding the device and software impacts understandings about traditional domestic values, such as privacy and the […]

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Additive Manufacturing Exploration

The project will involve making and designing reference parts, and then producing 3D scans of those parts and providing some measurement analysis. Documentation on collection and safety must be followed throughout. 3D printing is not only a very unique way of creating something, but it also gives its user a very wide range of design […]

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Underwater localization and target identification

In this project, we would model the underwater acoustic behavior. Using the model, we will calculate the distance to the source of the sound with high accuracy despite the underwater environmental conditions. The second part of our project is to classify the source producing the sound. Our algorithm will be able to detect and distinguish […]

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Designing and Developing Interaction techniques for webspaces in AR/VR

The objective of this project is to design and develop interaction techniques for Webspaces in Virtual/Augmented Reality. We will study and understand current techniques to interact with the websites via screens, how users access the information and media presented on the websites and the ways in which this presentation of information can be improved to […]

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Visual Analytic Tool for Lessons Learned Retrieval and Decision Making

According to the World Petroleum Council (WPC), the average age of employees in Oil and Gas companies is 50 years, and it is estimated that in the next 5 years 40-60% of them will retire. One consequence of this age-related crisis is losing the accumulated knowledge by retiring “gray-beards”. In this scenario, new software technologies […]

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