Employing Raman Spectroscopy for monitoring a vaccine manufacturing process

Vaccine antigen production is a process that entails numerous variables. In order to have a consistent and robust process, monitoring of process parameters and controlling output variables within a certain range is the best practice. To accomplish this objective, analytical tools are used, on-line, off-line, at line. Real time monitoring of the processes is advantageous as operating parameters can always be adjusted to keep the process in check.

Rapid scaling of viral spike protein production for SARS-CoV-2 testing using Phaeodactylum tricornutum

The SARS-CoV-2 virus is currently causing a pandemic that is overburdening the healthcare system and causing unprecedented economic disruptions on a global scale. A method called serological testing uses viral proteins to determine if the someone has been infected and has now become immune to the virus; however, it is currently very expensive to produce. If someone is known to be immune to SARS-CoV-2, then they can go back to work without spreading the virus.
The goal of the project is to facilitate a rapid test to identify people with immunity to SARS-CoV-2.

Accelerate development of new technologies and applications for advanced water treatment - Year 2

Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and for remediation of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life from one location to another by the discharge of ballast water.

Development of a softab nutraceutical formulation

Softab Technologies is a fast-growing company in Windsor, Ontario that is developing new formulations and methods to provide nutraceuticals: vitamins, natural extracts, and minerals in a revolutionary new form of chewable and dissolvable gel. They are working with a research team in the Department of Chemistry and Biochemistry at the University of Windsor to refine the formulation and make it flexible for utilizing a number of different ingredients so that it can be customized and tailored to specific ingredients.

Development and use of ezrin biosensors for high-throughput screening of novel ezrin inhibitors as anti-metastatic and immune-checkpoint blockade agents

Treatment of metastatic breast cancer is often unsuccessful and lead to 5000 deaths in Canada each year. Therefore, there is an unmet need for new drugs for prevention and/or treatment of metastatic disease. Ezrin is a protein marker commonly over-expressed in metastatic breast cancer. Preclinical studies show that blocking ezrin can significantly reduce metastasis in breast cancer models. In this proposal, the intern will develop novel biosensors to screen large numbers of compounds to find those with the ability to block ezrin’s activity in cancer cells.

Microalgae for the production of plant specialized metabolites of interest – Industrial PDF Fellowship Revision

Algae-C is a company specialized in algal biomass production. It enables on-site production of algae for a wide variety of sectors (aquaculture, nutraceutical, cosmetic and biofuel). To date, many fuels, pharmaceuticals and cosmetic products are extracted from plants. These valuable plant natural products (PNPs) are often produced in low quantities in plants and extraction methods can be long and expensive. Thus, there is much interest in metabolic engineering for developing microbial platforms to produce specific PNPs.

Development of a next-generation in vivo human gene-editing therapeutic platform - Year two

The over-arching goal of our project is to develop a robust next-generation gene-editing platform to repair the deleterious mutations that are responsible for genetic diseases such as Cystic Fibrosis and cancer. First-generation precision endonuclease technologies have been tremendous for in vitro gene disruption studies and ex vivo treatments, but there has been limited success at developing safe and effective in vivo human gene-editing therapies.

Bioorthogonal spin labeling approaches for high sensitivity electron paramagnetic resonance spectroscopy

In order to investigate proteins in their natural environment one can attach tiny reporter molecules to them that can be traced with appropriate instruments. However, these small reporter molecules may often cause strong perturbations to the functionality of the proteins, or cannot be seen due to experimental restrictions like low concentrations. Bioorthogonal chemistry aims to eliminate such experimental restrictions by using as inert molecules as possible to see how proteins really work.

The Role of Natural Background Radiation on Neurological Development and Processes

All species on the planet are affected by their environment: temperature, atmospheric pressure, daylight hours, and so on. These conditions affect how a species react to stress, grow, reproduce, and survive. Natural background radiation (NBR) is ever-present and has been prior to the evolution of all species. In order to study the effect of NBR on important biological processes, such as brain growth and development, we must remove it from the environment to see if it induces any changes. In order to remove NBR, a deep underground laboratory, shielded from NBR exposure must be used.

Characterizing the Mode of Action of Novel Boron-Containing Antifungal Agents for Crop Protection

Fungal pathogens of agriculturally significant crops pose a serious threat against global food security. This is exacerbated by the limited classes of fungicides that are commercially available for the farmers and the rapid emergence of resistance against the existing fungicides. Furthermore, resistance against agricultural fungicides can poses serious threat to human health as it can provide cross-resistance to the antifungal drugs that are used in the clinics world-wide.