Development of fisheries production metrics for offsets in Great Lakes wetlands

Since 1868, the Canadian government has enforced legislation to protect fishes and their habitats. In 2012, amendments to the Fisheries Act shifted legislation from the protection of fish habitat to the protection of fisheries productivity. The Act requires that proposed development projects include plans to mitigate negative impacts to fisheries productivity. In the event that impacts cannot be fully mitigated, the net loss of fisheries productivity must be negated using offsets – actions that would increase productivity elsewhere.

Evolutionary history of Cannabis sativa L.

Cannabis sativa is a multipurpose crop, providing us with fibers, seeds and medicinal compounds. Its current economic importance will likely drastically increase following its legalization in Canada. However, despite its economic potential as well as its long history of use by humans, we know very little about the evolution of this plant.

Anthropogenic impacts on the population dynamics of a critically endangered marine mammal

Economic development often has dire consequences for wildlife and environmental conservation. In Taiwan coastal waters, a small dolphin population is being affected by large-scale habitat loss and degradation resulting from development projects, pollution, vessel traffic and a massive fishing industry.

Edge Response of Understorey Plants, Lichenivorous Gastropods and Their Grazing Impact on At-Risk Lichens in Mixedwood Swamps

Clearcut logging and acid deposition affect plants, lichens and slugs (lichen consumers) and may facilitate the introduction and spread of alien invasive slugs, which can increase grazing pressures on at-risk lichens. The main research goal of this project is to improve our understanding of how clearcutting practices affect herbs and slugs and facilitate both the introduction of alien slugs and increased grazing on endangered lichens.

Characterization and quantification of adsorbed antigens in adjuvanted vaccines

Vaccines are one of the most important medical breakthroughs, proactively saving millions of lifes and reducing human morbidity. Yet there remains a need to make current vaccine formulations more effective and affordable, which requires testing and optimizing new formulations. In addition, there remains diseases for which there are no efficient vaccine. To develop and test new vaccines or vaccine formulations, Sanofi Pasteur and other manufacturers often rely on animal testing.

The anti-Helicobacter pylori properties and mechanism of action of probiotic Lactobacilli secretomes

Helicobacter pylori (HP) is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current anti HP treatments often fail because the bacteria have become resistant and they have serious side effects. We are looking into using molecules produced by bacteria called Lactobacilli that are a natural component of the human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients in a controlled and reliable manner.

The Effects of a Sub-Natural Background Radiation Environment 2km Underground on Biological Systems

Life on the planet has evolved in constant presence of radiation, some of which comes from space, and some of which comes from natural sources in the Earth. This natural background radiation (NBR) is a normal component of biological life. One way we can study the role of NBR in life is to see what the effects are when we take it away. This is difficult to do at the surface of the planet and requires that we go deep underground to shield out some of these parts of NBR.

A comparative analysis of glycan variation and its effects on therapeutic protein function

There are many exciting therapeutic applications for proteins. Many diseases are caused by faulty enzymes, which can sometimes be replaced. Antibodies and antibody-like molecules are being developed to specifically target cancers and other diseases. However, in order to administer these products, they must be made in a way that has minimal effect on the patient’s immune system. To make them viable commercially, they also have to be made in a robust, cost-effective process.

Improved Yield of Poly-4-Hydroxybutyrate Bioplastic via Genetic Modification in R. eutropha

Plastics are the prime contributor to the global litter crisis. Every second, a quarter tonne of non-degradable plastics enter the world’s oceans. Despite this, petroleum-based plastic production continues to increase, with more than 300 billion kilograms of virgin plastic produced annually. Our team is slightly altering the metabolism of a strain of bacteria to efficiently mass produce biodegradable plastic from hemp substrate. Unlike other biodegradable plastics, ours has excellent strength and flex characteristics.

Baseline parameters for application of human 3-D organoids as an in vitro model for studying neurotropic viral infection

Viruses that infect the brain, such as Zika virus, are a significant threat to public health in Canada since many are poorly understood, and no vaccines or antivirals exist to combat them. We are investigating the use of “mini-brain” organoids derived from human stem cells as a model to study Zika virus infection that mimics the physiology of the human brain. Here, we seek to optimize our methodology for infecting brain organoids with Zika virus.

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