Algae Wastewater Treatment Rosebud Pilot

Symbiotic EnviroTek Inc, in collaboration with the University of Calgary is undertaking a research project that will pilot and validate the efficacy and robustness of algae as a wastewater treatment technology and demonstrate a new business model for municipal wastewater infrastructure. The project provides a unique opportunity to optimize system performance in a pilot scale commercial environment, on site in the community to be served by the technology.

Developing Grassland Songbird Management Targets for Multi-Species Conservation on Mixed-grass Prairie Rangelands

The goal of this project is to develop management targets for grassland songbirds on native rangelands in western Saskatchewan. This research will identify grassland conditions required by priority species and examine how these differ between species and throughout prairie regions with very different soil and moisture conditions.

Immune modulation with checkpoint inhibitor antibodies targeting GITR or OX40 to improve cancer immune therapy with DepoVaxTM vaccine and metronomic cyclophosphamide

Immunovaccine Inc. is developing immune therapies for cancer using the company’s DepoVaxTM vaccine technology. DepoVax is a patented formulation provides controlled and prolonged exposure of antigens and adjuvants to the immune system, resulting in a strong, specific and sustained immune response. Immunovaccine’s translational research team is focused on improving responses in advanced cancers by combining DepoVax based vaccines with novel immune modulators in order to improve clinical trial design.

Development and proof-of-concept evaluation of 3D reconstruction molecular research tools

Traditional research microscopy tools are entirely adequate for conventional static analysis, however, the evaluation of more complex dynamic cellular processes require unconventional methods of acquiring, displaying, and rendering dynamic data. Autophagy occurs when some of a cell’s cytoplasm, referred as cargo, is enclosed by a membrane to form an autophagosome in order to be degraded and the products recycled. Autophagy is initiated to cope with stress, but we and others show that under non-stress conditions, specific cargos are targeted to the autophagosome.

Chromosome Engineering for Bioproducts from Methanotrophs - Year Two

Currently Metagenom Bio Inc. offers contract research services in environmental microbial species profiling. Applications for this service include the monitoring of biogas operations, greenhouses, and mining processes. Metagenom Bio wishes to offer solutions that use microbes to generate value-added products. Biogas reactors can break down waste products and produce methane, or natural gas. This methane can be burned, or some of it may be used to create materials using bacteria that can consume methane.

Identification of transcription factors involved in cannabinoid biosynthesis and glandular trichome formation - Year two

As an important medicinal plant, Cannabis sativa produces bioactive molecules that provide symptom relief for conditions such as severe cancer pain, nausea and vomiting associated with chemotherapy. The cannabinoid biosynthetic pathway that generates bioactive molecules has been studied for over a decade. However, understanding of transcriptional regulators that control cannabinoid synthesis is fairly limited. The primary site of cannabinoid biosynthesis is glandular trichomes that form on female flowers.

Development and application of a pollution biomonitoring tool for coastal British Columbia: A caged mussel health index

Healthy and productive coastal regions are highly important to Canada, both socio-economically and for the ecosystem services they provide. In 2015, the Vancouver Aquarium launched a new coast-wide initiative in British Columbia (PollutionTracker) to assess coastal health by generating high quality contaminant data for mussels and nearshore sediments. In the proposed study, Dr.

Diversity of coastal eelgrass communities and their importance for maintaining juvenile Pacific salmon - Year Two

On the coast of British Columbia, both eelgrass meadows and Pacific salmon species are declining, yet eelgrass community dynamics and reliance of juvenile salmon on these communities are poorly understood. We will assemble the first large-scale dataset from monitoring efforts of coastal BC organizations in order to assess eelgrass community diversity and structure across environmental and human disturbance gradients (including boating, fishing, and non-native species).

Inhibition of the fungal-specific histone deacetylase Hst3: a novel broad spectrum strategy to fight fungal pathogens

A number of fungal pathogens cause life-threatening infections in patients whose immune system is crippled. Among others, these include patients treated with cancer chemotherapy and patients who receive organ or blood cell transportation. Pre-term infants, elderly patients and patients in intensive care units are also at risk of developing life-threatening infections. Moreover, fungi cause very painful medical conditions such as vaginal infections. We discovered a fungal-specific enzyme that is essential for viability of the most common fungal pathogen, known as Candida albicans.

Enhanced and Conformation Specific G protein-coupled receptors (GPCRs) Expression for Autoimmune Diagnostics

G protein-coupled receptors (GPCRs) are proteins present on the surface of a cell that are the targets of >30% prescription drugs. These GPCRs are involved in various diseases ranging from hypertension, airway diseases to taste disorders. Detection of antibodies for GPCRs in various disease states is a challenging task. The main goal of this project is to develop novel methods and improve existing methods to overexpress a couple of GPCRs for potential use in diagnostic assays. The industry partner, Acudex Inc.

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