The role of complement factor D (adipsin) in the pathogenesis of the Stargardt phenotype in Abca4-deficient mice

Stargardt disease affects approximately 1:10,000 individuals and causes progressive, irreversible blindness. While primarily a juvenile disease, age of onset can range from childhood to adulthood. Although supportive care can help slow progression, there are currently no approved therapies and all patients are expected to reach legal blindness. Therefore, Stargardt disease represents an urgent unmet medical need.Oak Bay Biosciences, based in Victoria BC, is a preclinical biotechnology company with a goal to develop the first approved therapy for Stargardt disease.

The development of nanoparticle-doped redox active hole transport materials for next-generation solar cell cathodes

Koivisto Materials Consulting Inc (KMC) is a Canadian-owned and operated for-profit company that seeks to commercialize a low-cost optically transparent photovoltaic windows and coatings. KMCs proprietary technology is based on a modified dye-sensitized solar cell (DSSC) architecture and novel bio-inspired dyes. The two major advantages for DSSC devices are their optical transparency and ability to operate more effectively in diffuse light conditions (cloudy days, indirect sunlight, etc.); making them amenable for urban landscapes and all interior surfaces.

Marine ecosystem changes in Atlantic Canada: drivers of altered abundance and habitat use by waterfowl and marine birds?

Saltmarshes and coastal wetlands in Atlantic Canada are some of the habitats that have experienced the greatest decline in area over the past 400 years. Various organizations have monitored habitat change and bird use of these sites for decades, but no one has undertaken a comprehensive examination of changes in habitats or avian abundance, potential factors that influence those (including government policies), and the perspectives of local stakeholders on the successes and failures of conservation efforts in these region.

Optimising Reptile Conservation Interventions: Testing the Impacts and Efficiency of Commonly-used Methods to Improve Outcomes

Many Canadian reptile populations are declining and need help overcoming the challenges of the modern world. For this reason, numerous organisations and community groups have become involved in conservation actions, often intervening to safeguard eggs and hatchlings from the threats posed to these early life sages (e.g., predators, degraded habitat, roads and traffic). This project brings together experts in conservation actions with leading researchers in reptile biology to examine how we can improve the success of ‘incubation and release’ conservation interventions.

Facilitating Indigenous co-management of wildlife in Manitoba through collaboration on sustainable camera trap monitoring

This project aims to build strong collaborations with Indigenous communities across Manitoba to monitor large mammals using camera traps. The goals of this study are to facilitate Indigenous co-management of wildlife with the provincial government in Manitoba and to inform management of declining species, especially moose, with regards to the factors which are driving decreasing population sizes and distributions.

Using long-term monitoring data to quantify the impact of white-tailed deer reduction on vegetation and avian communities at Long Point, Ontario

Through analysis of vegetation data collected between 1991 and 2021 in Long Point National Wildlife Area, it is the goal of the research to identify trends and changes in sand dune vegetation communities following a reduction of white-tailed deer browsing pressure. By evaluating the rate and level of change in vegetation diversity, structure, and composition, recommendations can be identified for land managers to assist in achieving effective management of protected areas in relation to deer populations and resulting community impacts.

Community-based water monitoring and two-eyed seeing in the St. Marys Area of Concern

This project aims to bring Indigenous and Western ways of knowing together to generate actionable community-based data and information to influence local and regional water management and related decisions in the St. Marys River Area of Concern. Led collaboratively by the Garden River First Nation, NORDIK Institute (Algoma University), and Waterlution, delivered in partnership with four other organizations, we propose a pilot project that will train Indigenous community members to monitor water quality over a condensed monitoring season (i.e., as a proof of concept).

Size Spectra Modeling to Assess Productivity, Recovery, and Sustainable Levels of Community Harvesting of Eastern Canadian Marine Shelf Ecosystems

Off the east coast of Canada we observe some marine ecosystems that are still recovering from prior overexploitation, such as the Newfoundland sh elf, while other regions have witnessed recent expansion of fishing industries, such as the waters off of Nunavut. This project seeks to analyze trends in overall ecosystem health and to assess the overall impacts fishing acti vit ies have on fish and invertebrate communities from the southern Grand Banks to northern Nunavut using a technique called size spectra modeling.

Complex Gill Disease Initiative

Complex gill disease affects millions of farmed Atlantic salmon on the Pacific coast of North America, each year. This disease results in hundreds of millions of dollaras in lost revenue for the industry, yet there are few tools for early diagnosis of the disease/syndrome and no current treatment/intervention strategies that work to control it. The CGDI project aims at developing tools for early diagnosis and testing of new intervention and management strategies to resolve and control the disease.

Microchemical techniques to evaluate priority contaminant sources along the migration routes of Chinook (Oncorhynchus tshawytscha) and Coho Salmon (Oncorhynchus kisutch)

Adult Chinook and Coho Salmon migrate to a variety of marine regions around the North Pacific. Along these migration routes, the contaminants they encounter and consume will vary. These returning salmon are consumed by humans and Southern Resident Killer Whales, and the health risk they pose will be dependent on their migration routes and diets. Otolith microchemistry provides a record of where salmon have been throughout their lives.