Chemical and biological characterization of the non-tetrahydrocannabinoid profiles of medicinal plants

We propose to perform detailed studies that characterize chemically and biologically and the unaltered ancestral plant species of the Cannabis genus. Chemically, these studies will provide the chemotype profiles for each parental species for a spectrum of non-tetrahydrocannabinoid compounds. Biologically, these studies will provide the pharmacological profiles for each parental species.

Synthesis of Fluorinated Cannabinoids

The recent legalization of marijuana has sparked renewed interest in studying the health benefits of the non-psychoactive cannabinoids. Cannabidiol (CBO, 1, Figure 1) has emerged as a promising medicinal candidate due to its potential for the treatment of anxiety, and chronic pain. In 2018, the first CBD-containing drug, Epidio1ex, was approved by the FDA for the treatment of epilepsy. Despite its promise as a pharmaceutical, animal and human trials have found that CBD has low bioavailability and is prone to metaboHc degradation and excretion.

Synergistic Effects of Environmental Factors on Electrochemical Corrosion and Sulfide Stress Cracking (SSC) of a High?Strength Pipeline Steel

Sour corrosion originated from hydrogen sulfide in the pipeline has detrimental impact on the material’s surface of the pipeline, which ultimately causes cracks and pipeline failure. The mechanism behind this sour corrosion is complex because several environmental factors control the degree of sour corrosion, such as, temperature, acidity of the environment, hydrogen sulfide concentration, chloride ion concentration. This study will provide a clear understanding of how these all factors participate in the corrosion process.

Synthesis of graphene and graphitic films

The overall problem to be addressed is the synthesis of graphene or graphitic coatings from the liquid phase. This work follows from a previous investigation, supported by a MITACS Accelerate grant, into the use of “poly(hydridocarbyne)” (PHC), a soluble carbon- hydrogen polymer, as a precursor for the formation of diamond- like carbon coatings. As a result of attempts to purify PHC by electrochemical cycling it was discovered that the surface of the polymer could be converted into a graphene or graphitic layer.

Photocatalytic Oxidation of Volatile Organic Compounds in Air

A new type of device that uses a combination of UV light, oxygen, flowing water, and titanium dioxide (a com-mon white pigment) is capable of removing volatile toxins from the air. This device will be investigated using a range of techniques that provide molecular insights into this process, and those insights will help in the rede-sign of the device to make it as effective as possible, in terms of energy efficiency, longevity, reusability, range of compounds removed, and speed of their removal.

Development and Understanding of ‘old’ and ‘new’ initiators for cationic polymerization

Butyl Rubber has become one of the most important polymers in the modern world, impacting everyone’s daily lives. Interestingly, the processes to make butyl rubber can be convoluted and while they are effective, it makes it difficult to fine tune the production to systematically improve yields. This project will use newly developed methods in our lab to explore this process in order to better elucidate the reaction in order to optimize the reaction conditions and develop new catalysts for the synthesis of butyl rubber.

Development of Lignin-based Polymers and Nanomaterials for High Performance Engineering Applications

Lignin, a substance in the cell walls of plants, is produced as a waste when wood is processed into pulps, papers, and similar products. In addition, this organic polymer exists in massive waste wood chips generated by various forestry and wood processing industry sectors. To advance the circular economy and diversify forestry products, there has been a recent surge of interest to isolate and reuse lignin, especially in manufacturing of novel bioplastics and lignin-based nanomaterials.

Extraction and identification of potential active ingredient from expired pharmaceutical drugs

Every year billions of doses of medications go unused by patients in North America. Some of these are returned to pharmacies for appropriate disposal, but the majority of these are discarded in landfills or flushed into municipal wastewater streams. Our goal for this initiative is to collect unused and expired pharmaceuticals and develop a sustainable method to extract the active compounds, and to establi

Tuning the Front End: Increasing Ion Generation for Enhanced Sensitivity in Mass Spectrometry with Multiple ESI Emitters

Mass spectrometry is a chemical analysis technique for determining the mass/charge ratio of molecules under study. The instruments used for this technique require the compounds be transformed into gas-phase ions. This process is extraordinarily difficult with Nobel prizes awarded for the two most common methods. One of these methods is electrospray ionization where dissolved compounds are pumped through a tapered needle or emitter that is held at an electrical potential difference from the mass spectrometer.

Achieving consistently flavoured sour beers through better chemical understanding

The popularity of sour beers is continuously increasing. Producing sour beers is time consuming and obtaining a consistent flavor profile over multiple batches can be challenging. This in addition to scaling up production to meet customer demands can negatively influence the quality and flavor of the beer. This project aims to develop advanced analytical techniques to help understand the relationship between chemical composition and flavor.

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