Chronic inflammation is the common denominator for various diseases, including atherosclerosis, age-related macular degeneration (AMD), obesity, type-2 diabetes, liver diseases and even cancers. In most cases, this inflammation is the result of massive pro-inflammatory macrophage infiltration in tissues, due to their aberrant signalling and dysfunction, in presence of fat accumulation. The CD36 scavenger receptor has been shown to be key player in inflammation, with its TLR2 co-receptor.