Investigation of Raman Spectroscopy for Commercial Clinical Chemistry Applications

The project aims to address the issue of the lack of access to basic blood tests in a majority of the world’s population. We will explore the potential of Raman spectroscopy to provide a reagent-less alternative to traditional clinical chemistry methods. By proving that Raman spectroscopy, in conjunction with advanced machine learning, is able to quantitate critical yet low-concentration analytes, it is possible to develop a purpose-built, commercial, reagent-less clinical chemistry analyzer platform providing critical insight into the health of patients in low resource settings.

Lock-in detection of Raman resonance (LIDORR) in the presence of overwhelming fluorescence

Efforts to sequester atmospheric carbon in soil require effective monitoring methods. Soil water content confounds the conventional application of infrared absorption. Raman spectroscopy contends well with water, but suffers from the overwhelming fluorescence typically encountered in the analysis of soil samples. Here we propose to combine an modulated two-colour illumination scheme with antiphase lock-in detection that will serve to suppress fluorescent backgrounds and uncover Raman signatures of organic substances captured in soils.

Formulation of sustainable amino polyolefin coatings with improved adhesion and corrosion protection

Corrosion is the destructive attack of a metal by a chemical or electrochemical reaction with its environment. Corrosion of industrial and mechanical infrastructure causes severe economic losses. Canadian corrosion-related expenses amount to $41 Billion CAD annually. The extensive oil and gas pipeline networks in Canada require approx. $1 Billion CAD annually for replacement and/or maintenance. Catastrophic, corrosion-related accidents in the pipeline sector pose a severe threat to the environment, property, and human life.

Understanding the fate of tin in cyanide-free bronze electrodeposition baths

The Loony is a symbol, recognized by all Canadians. While it looks golden, the Royal Canadian Mint is producing its yellow color with an alloy coating on the coin surface. Yellow bronze is a hard and esthetically pleasing material that can be used as a coating for such coins. Internationally, yellow bronze coatings are predominantly produced from cyanide-based electroplating baths. This comes with significant risks to workers and the environment, regulatory restrictions and costs for waste treatment.

Synthesis, evaluation, and scale-up of sulfur-containing lipids

In 2021, over 2.2 billion doses of lipid nanoparticles containing mRNA are to be produced. The world’s largest vaccination campaign for a truly devastating pandemic was initiated as a result of technology developed by the principles in this application. RNA-based vaccines have been the fastest vaccines to be ever developed, with some of the highest efficiencies reported. In order for mRNA to exert its function, it needs a delivery system to take it from outside to the inside of a cell.

Low cost SERS substrates with rapid manufacturing

The proposed research will develop cost-effective substrates for application in Surface Enhanced Raman Spectroscopy. The substrates will be made using self-assembly methods for nanomaterials in aqueous medium
and a final step of simple filtration. The nanoscale material will provide high sensitivity as a SERS substrate for detection of specific chemicals and microbes.

Validation the performance of Porous Selective Polymers (PSP) devices for clinical application

This project aims to validate and explore the application of tailored polymeric materials developed in the department of chemistry at Memorial University of Newfoundland (MUN) for chemical analysis. The main application of such material is in the sample preparation and reducing the workload in laboratories. The materials will be used to treat the various samples such as water (i.e., drinking, river, and sea water) food, and biological samples.

Developing Methods for Quantification and Characterization of Fucoidan Present in Laminaria Digitata Extract

Using simplified language understandable to a layperson; provide a general, one-paragraph description of the proposed research project to be undertaken by the intern(s) as well as the expected benefit to the partner organization. (100 - 150 words) 7 Fathoms Seaweed Skincare (7FSS) is a small business that has developed products which incorporate an extract of Laminaria Digitata seaweed. The extract is prepared using a proprietary method and customers have reported dermatological and other benefits to using their products.

Enabling all-printed, flexible large-area perovskite solar cells

Climate change has been a top concern of Canadians for the past several years. Canada is among the 3 top global CO2 emitters per capita. Our goal is to develop and commercialize a cheaper solar energy harvesting system to help Canada decarbonize its economy.
Silicon has the most mature technology in the photovoltaic market. Silicon solar cells are primarily used in solar farms or installed on rooftops. Their installation is costly and requires architectural modifications preventing tenants from using solar panels due to the lack or limited permission for any architectural changes.

R&D to Design a Sustainable SolvoMetallurgical Process for Extraction and Recycling of Platinum Group Metals (PGMs)

The project will focus on a new branch of metallurgy, SolvoMetallurgy to apply green and bio-degradable solvents for selective extraction of Platinum Group Metals (PGMs). The research will provide industry with a solution for sustainable extraction and near zero environmental impact of PGM extraction from secondary and primary resources. The proposed methodology will eliminate wastewater and toxic off-gassing in the process of PGM recycling while reducing the energy consumption and carbon footprint of PGM recycling/extraction production.

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