Macrocyclic peptides as chemical probes for protein-protein interactions

Peptides control a vast range of intra- and intercellular processes. However, linear peptides suffer from instability and poor cell permeability, which limits their application as therapeutic agents. In contrast to linear peptides, cyclic variants are more resistant to both exo- and endoproteases, which explains the therapeutic potential of this class of molecules. Peptide macrocycles have shown remarkable capacity for functional fine-tuning.

Development of high-performance electrochemical enzyme biosensors based on carbon nanotube complexes with conjugated polyelectrolytes

A simple and facile route for the construction of highly sensitive electrochemical enzyme biosensors has been proposed using carbon nanotube (CNT) complexes with a conducting poly(thiophene) polymer. Glucose oxidase was used as a model enzyme for the construction of the advanced biosensors. Glucose biosensors, exhibiting sensitivity higher than any biosensor based on CNTs and other polymers reported, were prepared by depositing CNT-polymer loaded polymer layers that contained entrapped glucose oxidase onto gold electrodes.

State-of-Charge Display Device for Disposable Batteries

In the last ten years the market for mobile devices and portable electronics has never ceased to grow, creating a rising demand for batteries. However it is practically impossible for consumers to identify their actual state-of-charge leading to the disposal of still viable batteries. In the past battery manufacturers have developed “on-board” testers allowing consumers to gauge the charge but these indicators have been discontinued due to their lack of reliability and their active feature discharging the battery while in use.

Study of the interaction of gold with organic additives in thiosulfate leaching solution

The mining industry represents a large part of the economy in Canada. Ontario is the largest producer of gold in the nation, producing 53% of Canada's total minerals production in 2007 [1]. Despite its high toxicity, cyanide is commonly employed in the extraction of gold from its ore. Its use represents an environmental hazard due to possible leakage or spills into soil and groundwater causing destructive ecological effects in the surrounding areas. Several environmental accidents around the world have been reported due to the ttse of cyanide in gold mining.

Alternative Hydrogen Sources For Portable Fuel Cells

In the current climate of environmental awareness the need for alternative energy sources is undeniable.  In this respect hydrogen gas is a frontrunner as a clean burning fuel, with water being the only by-product.  Coupled with a PEM (polymer electrolyte membrane) fuel cell, hydrogen is a promising alternative to gasoline for automotive applications.  While significant progress has been made, this technology is still in its infancy.  A significant drawback in this technology lies in the storage and transportation of hydrogen within a vehicle.  To this end, our project focuses on the delive

Using electronic detection to enhance performance of HPLC equipped with UV-Vis optical detection

In this internship, UNS-Tech will partner with Prof. Woolley to detect products of interest to his lab using UNS-e-chip. The antibiotics, developed by Prof. Woolley, are novel systems that can be activated by light or enzymes. The assay will employ UNS-Tech’s state-of-the-art electronics-based detectors for HPLC. The results will be analyzed and the findings will be published in scientific journals. The intern will benefit from this internship by gaining tremendous knowledge of synthesis of products of great value to the pharmaceutical industry.

Optimization of Optical Signal in Microarrays: Predicting properties of polycrystalline ZnO coatings

This project addresses an important need for more reliable diagnostics and health care testing. DNA microarray technology coupled with PCR has enabled a dramatic improvement in high]throughput clinical diagnostics, with analogous advances from other biomolecular and chemical microarrays in areas of metabolomics, proteomics, etc. There is still room for improvement, however, in boosting signal from low]replicate samples and reducing false positives from either fluorescence noise or lower fidelity hybridization or coupling.

Nanoscale Antenna Design and Fabrication

Environment-friendly, renewable energy sources are required to meet the world's ever increasing energy demands. While conventional silicon-based photovoltaic solar cells provide an attractive alternative to fossil fuel based energy sources, their inherent high cost has limited their use. The optical rectenna solar cell (ORSC) represents a potential high efficiency, non-silicon based, economic alternative. This internship aims to investigate the design and fabrication of ORSC devices.

Determining advantages of electronic detection in high performance liquid chromatography

The interns will spend time in the company lab to build and test proprietary electronic chemical detectors. These will be tested and undergo quality control measures in Universal NanoSensor Technologies’ lab. Once deemed robust, these detectors will then be used concurrently with present art detectors in a real-world, cutting‐edge, applications‐driven setting so that direct comparison can be made. The interns, under the guidance of the supervisor and other students involved in the lab, will perform head‐to‐head tests using both these detectors in place.

Scaling up of the Synthesis of new Polymers for Pharmaceutical and Cosmetic Use

The use of natural compounds in the preparation of polymers may yield materials with the desired properties and better bioacceptance. Bile acids are natural amphiphilic compounds biosynthesized in the liver and have been used in the making of such polymers. In this project, the research team use cholic acid, a major bile acid, in the preparation of new star‐shaped polymers. Poly(ethylene glycol) chains and functional groups can be attached to the cholic acid core to obtain star‐shaped polymers.

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