Scaling up of the Synthesis of new Polymers for Pharmaceutical and Cosmetic Use

The use of natural compounds in the preparation of polymers may yield materials with the desired properties and better bioacceptance. Bile acids are natural amphiphilic compounds biosynthesized in the liver and have been used in the making of such polymers. In this project, the research team use cholic acid, a major bile acid, in the preparation of new star‐shaped polymers. Poly(ethylene glycol) chains and functional groups can be attached to the cholic acid core to obtain star‐shaped polymers.

Design and synthesis of co-polymers for novel photo/electrochromic hybrid materials

SWITCH Materials is developing a revolutionary new type of film for application in SMART window technology. The proposed SWITCH film will allow windows to automatically darken when exposed to sunlight, blocking harmful Ultra Violet and Infrared Radiation and improving occupancy comfort while also providing the user the ability to, at the flick of a switch, “clear” or “bleach” the windows on lowlight days to allow natural day light through the window.

Computational design for improving the affinity of peptide ligands for carbohydrate-binding

Diarrhoeal diseases pose a serious global problem, especially in the developing world. Shigella flexneri Y, the most deadly species of Shigella, is endemic in most developing countries. An antibody, SYA/J6, against Shigella flexneri Y was developed. Studies have shown that MDWNMHAA is a weakly immunogenic peptide against the antibody SYA/J6. The research team at Zymeoworks Inc., a computational biotechnology company, is hoping to improve the binding of MDWNMHAA to SYA/J6 in order to generate a more effective immune response. This could lead to a vaccine for Shigella flexneri Y.

Use of LUMINEX and Lateral Flow Devices to Measure Fungal Antigens

The purpose of this project is to undertake development research to apply methods for analyzing proteins from fungi that grow on damp building materials that are antigenic in humans. This will allow the presence of the fungal antigen to be detected in dust samples by methods similar to those used for pregnancy test kits and those used for measuring house dust mite and animal allergens in houses. In this case, such methods are used to aid in the rapid assessment of houses and buildings with potential mould problems and in epidemiology studies.

Computational/Experimental Protocol for Development of a Therapeutic Agent for Treatment of Tuberculosis

It is estimated that one third of the world’s population is infected by Mycobacterium tuberculosis. With the emergence of drug resistant tuberculosis, the World Health Organization has declared tuberculosis a global health emergency. UDP-galactopyranose mutase, an enzyme essential for tuberculosis bacterial growth and infection, will be studied by a protocol which combines advanced NMR and computational modeling techniques.

Antibody Modeling Using a Combined Computational/Experimental Protocol

The proposed project combines structural biochemistry with high-performance molecular simulations to generate valuable insight into the development of the next generation of ligands that can be used to develop vaccines. The collaboration between the academic and industry partner creates an ideal opportunity to combine theoretical and experimental approaches for better lead generation and development of scientific knowledge. Zymeworks will have an opportunity to validate its ZymeCAD™ platform for pharmaceutical applications.

New Polymers for Use in Flame Retardant Paper and Flame Retardant/Decay Resistant Wood

The intern will apply the phosphorus polymer previously developed at UBC, as well as the H2O-soluble phosphorus polymers which will be prepared during the first two months of this internship, to the surface of paper and wood samples to study the fire retardancy of the paper samples and the fire and decay retardancy of the wood samples. The intern will react the H2O-soluble phosphorus polymers with pulp and wood samples in aqueous solutions and determine how much of the polymers are retained by the pulp and wood samples.

Ab-initio Simulation on Morphology and Reactivity of Supported Platinum Nanoparticles

Polymer Electrolyte Fuel Cells (PEFC) are under intense research as highly efficient and clean power sources for transportation and portable applications. The Cathode Catalyst Layer of PEFC, usually formed by carbon supported Pt-based catalyst, is considered as the most critical component. It involves all processes relevant for fuel cell operation. Cost and abundance of Pt is the major challenge for the commercialization of PEFC technology. Recent results in experiment and modeling indicate that catalyst activity and utilization could be improved by substantial factors.

Simulation and Mathematical Modeling of Unsupported Pt Nanoparticles for Fuel Cell Electrocatalysis

Polymer Electrolyte Fuel Cells (PEFC) are under intense research as highly efficient and clean power sources for transportation and portable applications. The Cathode Catalyst Layer (CCL) of PEFC, usually formed by carbon supported Pt-based catalyst, is considered as the most critical component. It involves all processes relevant to fuel cell operation. Cost and abundance of Pt is the major challenge for the commercialization of PEFC technology. Recent results in experiment and modeling indicate that catalyst activity and utilization could be improved by substantial factors.

Prediction of Complex Molecule Structures with HDX Mass Spectrometry-guided Molecular Dynamics Simulations Part II – Generalization and Parametrization

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is a powerful emerging experimental technique which provides important information about the solvent exposed area of complex molecular systems that is not readily available through existing technologies. HDX-MS can be applied to the specific cases of small molecules binding to protein systems, which is very important for the understanding, and new design, of therapeutic compounds, including chemotherapeutic cancer drugs.

Pages