Enzyme-instructed siRNA release and functional self-assembly of peptide-based delivery system

RNA interference mediated gene silencing provides one of the most effective treatments for many genetic diseases such as cancer and viral infection. However, due to the many difficulties siRNAs would face during systemic pathway, a delivery system is needed to protect it from degradation and endosomal entrapment, and also to facilitate the unloading of the cargo. In such case, the main objective of this project is to produce a phosphorylation-mediated peptide-based siRNA delivery system.

Supercritical Fluid Extraction of Cannabis for processing into various forms

Avana Canada Inc. is undertaking the development of a supercritical fluid extraction (SFE) unit within its GMP facility for cannabis processing. Cannabis has been used for medicinal purpose for a long time. SFE is currently the best technology for bioactive components extraction. By carefully changing the operational parameters, the solvent strength can provide selectivity to the extraction process, thus adjusting potency of the extract product.

Development of an Autonomous Pipeline Control System

Autonomous operation of oil and gas pipelines is being introduced to the marketplace by utilizing advanced process control and Artificial Intelligence. This Project will explore the use of advanced optimization algorithms in combination with autonomous operation to further increase efficiency of pipelines by continually driving pumps, compressors and valves to achieve the lowest cost operation.
Expected benefits of these efficiencies will be to increase the effective pipeline capacity without building new pipelines, while reducing the amount of energy required in a pipeline’s operation.

Coupling the liquid pool and wellbore hydraulic module of the “Prediction and Optimization Software Package” – Part 2

In the last decade optimization is expanded in many applications from food production to sophisticated applications such as engine fuel efficiency. In the proposed package, it is tried to apply optimization techniques along with physics based analytical and semi-analytical methodologies to create a compelling framework which can help thermal-process based oil industry to reduce their GHG and also better evaluate their CAPEX. Many SAGD projects are overspent on their facilities due to under prediction or overprediction of their oil production expectations.

Fabrication of High-resolution Perfluoro-polymer Imaging Fiber Bundle via Electrospinning and Stack-draw Technique

This project will be with Vena Medical that focused on creating a forward viewing imaging microcatheter to provide a real-time navigational perspective for interventional physicians. The Vena Microcatheter will make interventional procedures faster, easier, and safer for both patients and physicians. This project will investigate the novel polymer optical fiber with high flexibility and high-quality image transmittance for medical microcatheter.

Manufacturing and stabilization of nanocellulose in a scale up process using functional maleates as a colloidal dispersion

Cellulose nanocrystals (CNC), a form of cellulose, shows a lot of promise in the development of sustainable materials thanks to its unique properties such as high performance, large surface area, is readily available, renewable, and biodegradable. Early methods to synthesize CNC have not been very successful. In order to isolate CNC, to make them ready for fast production of industry needs, these challenges need to be resolved by chemical modifications.

Les microplastiques et contaminants associés dans l’estuaire et le golfe du Saint-Laurent : caractérisation environnementale, sociale et bioaccumulation ou dépuration chez les bivalves

Ce projet propose de définir les enjeux socio-environnementaux et socio-économiques reliés à la présence de microplastiques (MP) marins dans l’estuaire et le golfe du Saint-Laurent, une région hydrologique complexe sous-étudiée vis-à-vis cette problématique. Ceci permettra d’orienter les décisions visant à protéger l’environnement tout en soutenant les secteurs maritimes, notamment ceux reliés aux ressources marines commerciales.

Agrégation et enlèvement des nano-microplastiques par l’entremise de sels métalliques préhydrolysés et de polymères organiques : impact d’une préoxydation par l’ozone et d’une préexposition aux rayons UV sur l’efficacité d’agrégation

La production mondiale annuelle de plastiques est estimée à plus de 335 millions de tonnes et risque de doubler d’ici 20 ans. De cette production, moins de 26 % est actuellement recyclé; plus de 74 % de ces plastiques sont donc redirigés à l’enfouissement ou relargués dans l’environnement. Il est clair que l’accumulation des plastiques dans les eaux de surface pose un enjeu important sur la santé publique et menace les écosystèmes aquatiques.

Development of nanoscale and microscale delivery vehicles for plant immune aids using protein coacervation and spray drying

Modern pesticides have revolutionized agriculture. However, growing concerns with pest resistance, environmental run-off, and a lack of capacity to deal with abiotic stresses associated with drought or extreme heat (critical issues with regards to climate change) demand new solutions. Suncor has developed new plant immune aids that address these challenges by fortifying the immunity of plants, with demonstrated efficacy in crop models. However, current formulations suffer from low bioavailability and low leaf retention, resulting in the need for frequent and costly re-applications.

Pelletization of Forest Wildfire Fuels in Western Canada

Forests in British Columbia have significant areas that need to be managed to limit the danger of fire and disease. Under current management approaches, there are few cost-effective options available to areas that are not already regularly harvested. A holistic analysis of pelletization of these materials could show that the sale of wood pellets, as well as the reduction in fire suppression and forest management costs and the increase in tax base would generate a net profit to the province and the businesses associated with the management.