Chronic low-back pain (CLBP) is a significant health issue in North America. CLBP patients demonstrate structural changes to and reduced function of the multifidus muscle, which is important to low-back health. Neuromuscular electrical stimulation (NMES) is a treatment used to improve pain and function in low-back pain patients, but is frequently painful. Our partner has developed a device (the StimaWELL 120MTRS Stimulation Mat) that is less painful for patients, but its effects on multifidus structure and function are unknown.
The objective of this proposal is to develop a new candidate recombinant protein vaccine for the new coronavirus disease 2019 (COVID-19) based on a novel protein delivery and adjuvant technology, iPDT. If successful, this research will advance another COVID-19 vaccine candidate(s) to the pipeline toward clinical use. The causative agent of COVID-19 is SARS coronavirus (CoV)-2. The spike (S) protein of CoV protrudes from and covers the surface of virus particles and interacts with host cell to initiate infection.
Scleroderma is a rare autoimmune connective tissue disease that damages skin and internal organs. Although many Canadians with scleroderma live at home with supported care from family, seeing their loved ones struggle with reduced participation in activities of daily living caused by disease symptoms often causes caregivers emotional distress in their caregiving role.
To improve the health and economy of Canada, Achu Health has developed an application based on a machine learning algorithm that uses data collected from a smartwatch to predict illness in individuals using the application. Achu Health aims to assess the scientific rigour of its application to ensure that the evaluation of the effectiveness can take place. Therefore, the partnership with the POP-PA laboratory at the University of British Columbia will help find and address any issues with the current stage of the application.
The North American Waterfowl Management Plan (NAWMP) is an international partnership to conserve abundant and resilient waterfowl populations and sustainable landscapes. Through their work with the four Canadian NAWMP Joint Ventures, Ducks Unlimited Canada collaborate on waterfowl and habitat management issues, including social issues that are relevant to wetland and waterfowl conservation.
Hypoglycemia or low blood sugar is a phenomenon that results from excess insulin or strenuous exercise in diabetic patients. If untreated, this can quickly lead to dizziness, seizures and even death. In healthy individuals, the body is able to compensate for these fluctuations and restore blood sugars to normal levels by lowering insulin and raising glucagon. In those with diabetes, they are unable to do this and struggle with hypoglycemia.
Diabetes mellitus, a common metabolic disorder, exhibits neuropathic complications that can eventually lead to disabling pain (Todorovic 2015). This is attributed to hyperglycemia/high glucose resulting in neuronal hyperexcitability (Todorovic 2015). Importantly, diabetes-evoked neuronal hyperexcitability and neurotoxicity can be caused by alterations in voltage-gated sodium channel (VGSC) expression (Hong, Morrow et al. 2004), resulting in changes in the sodium currents lowering the action potential threshold (Hong, Morrow et al. 2004, Chen, Wang et al. 2018).
Eli Health is developing a novel biosensing device to monitor sex hormones in saliva and a mobile application that leverages machine learning to interpret them. The mission of the organization is to enable women to take control of their health across their lives. It will first commercialize the device for fertility and contraception applications. In collaboration with Seasy Huang and academic supervisor Dr. Charlotte Usselman, this research explores other use cases where of hormone monitoring can have a positive impact on women's health.
Within their ergonomics process, automotive manufacturers rely heavily on computer simulation technology, specifically "Jack" (Siemens PLM, Plano, TX). Advancements to "Jack" provide users the ability to create workstations, yet much time is required to produce a single simulation. This 3-year industrial collaboration will reduce the time necessary for their completion and, improve on the accuracy of digital simulations.
A central venous catheter (CVC) is a thin, silicone tube that a doctor may insert into the vein of a patient to deliver medications directly into their bloodstream. If the patient does not need constant medication, nurses fill the CVC with salt water to keep the tube open. This is called ‘locking’ the CVC.
Because a CVC is a foreign object introduced into the body, it may put already vulnerable patients at risk of developing complications such as infection and blood clots. Although locking with salt water keeps the CVC open, it offers little protection from CVC complications.