Proof of Principle Application for Biosensors in Animal Models

NXTSens has developed an implantable continuous monitoring, stand-alone and potentially mass-producible microsensor for accurate monitoring of tissue pressure and temperature in damaged limb muscles to better diagnose ACS. The proposed research will involve several sub-projects that include: i) develop appropriate surgical models for the accurate and reproducible placement of the microsensors in rodent compartments; ii) test the performance of a prototype microsensor in a relevant cadaver model.

Moving to Breathe, Breathing to Move: An interdisciplinary study on the benefits of choral and dance exercise for people with neuromuscular conditions

In this collaborative project with Muscular Dystrophy Canada (MDC), we will design and run choir singing and dancing programs for people with neuromuscular conditions, in order to study whether it improves their quality of life and their ability to breathe. Both singing and dancing have been shown to have significant medical and quality of life benefits for people with other kinds of disabilities, but little research has been done with those who have neuromuscular conditions. This will also be the first study to include participants who rely on ventilation technology to breathe.

Investigating the Change Management Process in High Performance Sports Organisations Related to Performance Management

Organisational change is part of life for sports teams, however, research suggests that despite how often change initiatives occur, the success rate for organisations achieving their desired outcomes is less than 30%.
The aim of the study is to investigate how top level sports organisations manage change and to compare the different approaches adopted by various sports in countries around the world.
This study will interview sporting directors and general managers from around the world in order to:
1) identify how sporting directors identify, research and plan change initiatives, with a compar

Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI - Year two

NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS) that utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of this project will be to incorporate advanced computer algorithms to automatically classify the quality of high-resolution structural brain Magnetic Resonance Images. The advanced computer algorithms will include deep learning algorithms.

Physiological assessment of cochlear and auditory nerve integrity in children suspected of auditory processing disorder - Year two

Nearly 2 % of school-aged children face difficulty in understanding speech in the presence of background noise. These children are often referred to audiology clinics for a central auditory processing (CAP) assessment. The purpose of the referral is to rule out an auditory processing disorder (APD). The American Speech-Language-Hearing Association recommends to include electrophysiological measures to assess the neural integrity in children sAPD. However, less than 15 % of audiologist include the electrophysiological measure in their battery of assessment.

Turning off the “switch”: Preserving the analgesic actions of the endogenous opioid pathway in IBD

Abdominal pain is a debilitating symptom for many patients with inflammatory bowel disease (IBD). An endogenous opioid system emerges in the intestinal tissues during chronic inflammation that acts to dampen such pain and could prevent the need for strong opiate drugs like morphine that can cause serious side effects. However, we have discovered that psychological stress, common in patients with IBD, can block the beneficial analgesic actions of these endogenous opioids and paradoxically can cause them to actually stimulate rather than relieve pain.

Detection of insulin using a novel capturing system

Insulin is a hormone released from the pancreas, which controls the level of glucose in blood. Diabetes is a disease characterized by a lack of insulin production or impaired insulin action. Here, we propose the development of a novel system based exclusively on the measurement of insulin using capturing molecules with high affinity to insulin. This method will provide an affordable and simplified method to be used not only in point of care but also by the patient at home.

A novel therapeutic drug for selective treatment of castration-resistant prostate cancer with MTAP deficiency

Chemotherapy is currently the most effective approach for treatment of advanced cancer. However, chemotherapeutics do not differentiate between malignant and normal cells, and lead to serious side effects. Recent findings indicate that a substantial proportion of cancers, as distinct from normal tissue, are deficient in an enzyme called methylthioadenosine phosphorylase (MTAP).

Story through Mechanics - the design and evaluation of engaging narrative through the use of non-cinematic, mechanics-based techniques in casual games

There are many examples of video games that have successfully used cutscenes and in-game dialogue to deliver engaging stories. But there is one market segment where story hasn?t been a focus, namely casual games. Given such games are primarily intended for a broader audience, have a much smaller budget, and typically focus on short experiences - such as solving puzzles, there may be no real need for story. But there have been some standout casual games that have used setting, theme and emotion very effectively, without the use of heavy scenes or dialogue.

Mechanisms of the relationship between ageing and dementia.

As our population ages, the burden of dementia is growing. Alzheimer's disease (AD) is the most common cause of dementia; currently we do not have any disease-modifying treatments for AD. There is motivation to better understand the mechanisms of AD development and expression to control the burden of disease.

Frailty is related to neuropathological features of AD (i.e. plaques and tangles) and clinical dementia. Frailty and AD-type dementia share many risk factors and clinical features.