Appraising Medical School Admissions Tools for Implicit Bias

This research considers the diversity profile of applicants to medical schools across Canada and with specific respect to the Undergraduate MD Program at McMaster University and contemplates the degree of potential implicit bias inherent to medical school admissions systems. In particular, this work will seek to understand the degree of statistical association between applicant social identity characteristics and performance on merit-based admissions tools operationalized by medical school admissions committees.

Optimizing precision oncology at BC Children’s Hospital

Precision medicine, where treatment is tailored to the individual patient, offers much potential to improve outcomes for children with cancer. However, selecting the right drug for each child remains challenging and new approaches to identify the most effective therapy are needed. In this project, interns will work directly with staff at BC Children’s Hospital (BCCH) and UBC researchers to establish preclinical screening of patients’ cancer cells with specific drugs to see which one works best.

Community Based Participatory Research Strategies for Combining Creativity with Sustainability in the Arts and Beyond

The proposed Creativity and Sustainability post-doctoral fellowship will be situated at Mass Culture (MC),and executed in cooperation with University of Toronto Scarborough’s (UTSC) Urban Just Transitions(UJT). Over the years, MC and the scholars involved in UJT have experimented with various forms ofcommunity-engaged methods in order to generate impactful research that will inform policy-making andadvocacy work to address inequities in their respective fields of interest.

Development of cGMP-compliant manufacture of activated eCB-MSCs along with in vivo evaluation

Research into equine stem cells as regenerative medicine has been ongoing for over 20 years. Stem cell technologies hold promise for healing musculoskeletal tissues and wounds, fighting bacterial infections, and treating inflammatory conditions, but definitive evidence of the safety and therapeutic efficacy of these technologies have not yet been proven. A major limiting factor for conducting clinical trials to prove safety and efficacy is the lack of sufficient cell numbers with reproducible, standardized, and characterized properties.

Individualizing high-intensity functional training (HIFT) for optimal fitness and health adaptations: exercise limitations and individualization with wearable technology

This project will bring together a motivated intern, an experienced researcher, and a nationally-ranked coach to solve a unique problem in the world of health and fitness. High-intensity functional training is a highly popular method of training, but is one that needs research on the physical and mental aspects to best design individualized training programs. With the addition of wearable technology during exercise, the research collaboration will identify the key aspects of the exercise training and the individuals who use it to optimize their adaptations to this training.

Novel Serum Hormone Sampling Methodology: Applications for Understanding Ovarian Follicular Waves during the Human Menstrual Cycle

The menstrual cycle involves a complex chain of events between the brain, ovaries, and uterus. At the beginningof a woman’s cycle, the follicles (fluid-filled sacs in the ovaries that contain the eggs) grow, then one follicle isselected for further growth and eventually ruptures to release the egg during ovulation. Previous research fromour group has shown that follicles grow in 2-3 waves throughout the cycle. This study aims to use a new methodof collecting blood samples to evaluate how hormones from the brain and ovaries regulate the growth of folliclewaves in the ovaries.

Model systems to Assess The in vitro efficacy of CFTR modulator tHerapies in Cystic Fibrosis (MATCH-CF)

Cystic fibrosis (CF) is a genetic disease is caused by changes (mutations) in a gene that produces a protein called the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is responsible for salt transport and when it does not work properly it leads to organ dysfunction. A new generation of therapies are now available that improve function of the CFTR protein and are known as CFTR modulators and they have contributed to improving the lung function and the quality of life for people living with CF (PwCF).

Generating and Characterizing Subtype Specific Versions of Oligodendrogenic Neural Progenitor Cells for the Treatment of Spinal Cord Injury

Spinal cord injury (SCI) leads to devastating sensory and motor impairments which severely diminish quality of life and currently have no cure. Although different cell therapies have been tested for SCI, many have been transplanted in a “one size fits all” approach and have insufficiently addressed patients’ diverse injuries. As such, many pre-clinical efforts have failed to be translated to a clinical setting. In the present study, we aim to generate and characterize three distinct versions of cells in order to promote patient-specific treatment of SCI.

Development of high protein canola using MAD7 gene editing

This project targets the improvement of seed protein content in Canola seed using genome editing. The development of high protein content in canola seeds has potential to be utilized in the production of plant protein ingredients and as a source of high protein feed in the dairy and aquaculture industry. AgGene, the partner organization is an Alberta-based startup company and will benefit from MITACS support to hire a high quality intern to facilitate the development of high protein canola by leading the transformation and identification of gene edited canola plants.

A pragmatic randomized controlled trial of a CKD specific telemonitoring platform to minimize adverse outcomes in high risk CKD patients

Advanced chronic kidney disease (CKD) patients require close surveillance, as CKD patients are at high risk of adverse events including death, acute dialysis initiation, emergency department (ED) visits and hospitalizations. Previous data from our population-based provincial study showed that there is a 10-fold increase in ED visits and hospitalizations related to kidney failure and its complications during the 30-day period before the start of dialysis.

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