Selective Ablation of Circulating Tumor Cells by Dynamic Photothermal Therapy

Cancer metastasis is responsible for 90% of cancer deaths. In metastasis, a group of cancer cells detach from the tumor, entre the blood stream and ultimately make new colonies in other organs. In this study we aim to develop a new technology to target these cancerous cells in the blood circulation with laser irradiation. We will use absorbents that selectively home to these cells in the blood. These absorbers are able to convert the laser irradiation to heat and consequently kill the cancer cells they are attached to.

Implementation and strengthening of the community enhancement program to assess theneeds of different residents living at Brightside

The purpose of the project is to assess the housing, community engagement, and social inclusion needs and challenges faced by different residents, many of whom are older adults and are residents in Brightside Community Housing Foundation. Also known as Brightside. A mixed method approach (dempgrahic questionnaire, survey and focus group) will be used in this study. The findings from this survey will guide Brightside’s action plan to improve housing security and offer community initiatives that are tailored to the needs of their residents.

Curating Anti-Colonialism: Re-imagining the Institution through a Decolonial Lens

Understanding that art galleries must position themselves as open learning communities, the MacKenzie Art Gallery (MAG) proposes internships in Indigenous and new curatorial practices. Canadian cultural institutions have long considered themselves above the political.

Evaluating Skill Transfer Between Canadian and Global South Midwifery Associations

The Canadian Association of Midwives (CAM) implements global programs in Africa and the Caribbean, building midwives’ technical skills and strengthening the capacity of midwifery professional associations in our partner countries.

An Integrated Interface for a Mixed Reality Based Medical Education System

How to build a medical education ecosystem and improve the learning outcome? Currently a medical education system based on mixed reality is missing and bad user interfaces can leave students confused and struggling instead of learning efficiently. The goal of this project is to leverage mixed reality technology, develop a medical education system, and make it easy to use.

Advanced Nystagmus System (ANSTM) as objective diagnostic tool for mild traumatic brain injury (mTBI) and concussion: A validation study using structural and functional magnetic resonance imaging

Annually, 2 million individuals in North America suffer mild traumatic brain injury (mTBI) or concussion (cost: $75 billion), with 200,000 in Canada. An objective tool is required to distinguish concussed subjects acutely from ontrols, and to predict who will develop chronic symptoms. The frontal lobes, the corpus callosum, and the thalamus play key roles in oculomotor movement and are sensitive to mTBI. Saccade Analytics (ANSTM) offers a quantitative and automated analysis of eye and head coordination; it will be tested to identify damage in mTBI.

Improving protein-ligand binding models using multidimensional, mixed-confidence training data

Artificial Intelligence is powered by data. In general, the predictive power of AI improves with higher data abundance and higher data quality. However, real-world datasets vary greatly in quality and quantity. In drug design, like many other tasks, there is an abundance of low quality data and scarcity of high quality data. This project will be developing new computational approaches to balance data quality and quantity to make the most out of all available information.

Development of a multifunctional in situ-forming scaffold with antimicrobial activity for treatment of complex wounds

Pressure ulcer is one of the top five leading causes for re-hospitalization of spinal cord injured patients. In general, there are three main difficulties associated with treating these ulcers: 1) Presence of cavities and tunnels which makes it difficult to treat with conventional regimens, 2) A high chance of infection and, 3) Susceptibility to weight-bearing pressure on bony areas of the body.

Discovery of Antimicrobial Agents from Marine Microbes

The general aim of this proposal is to discover new natural products with antibacterial activity of relevance to companion animal health. While numerous discoveries of natural products have been made, the rate of discovery of new natural products has declined in recent years. The strategy outlined in this project aims to provide a streamlined approach to the discovery of new bioactive natural products. Nautilus Biosciences is the partner organization that will benefit directly from this project.

Molecular effects of novel high-CBD Cannabis cultivars: from mechanisms to novel applications and therapeutics

With the legalization of cannabis, a serious issue facing Canadians is: how will consumers know their products are safe and created with their health in mind? Many Cannabis products claim diverse health benefits, ranging from treating pain to reducing inflammation and affecting tumor growth. While this is incredibly exciting, have all of these products been researched to ensure their claims are rooted in scientific proof?