The aim of the project is to design and test different chemical derivatives of betulinic acid as a treatment for cancer. It is well known that betulinic acid is able to specifically kill cancer cells, and so we have developed several derivatives to improve biochemical properties such as solubility or biodistribution but maintaining the toxicity for cancer cells. We will test these different chemical structures on different cell lines (normal and cancerous) and try to elucidate the mechanism of action of those compounds.
This study will validate the accuracy of a new artificial intelligence (AI) powered application, which has been developed to track communication and cognition during the babbling stages of development in the first year of life. Once validated, this app will be an asset to both parents and clinicians. It will be used by parents and will be suitable for informing speech-language pathologists and other clinicians about potential developmental communication/cognitive delays during this period.
The overall objective of the proposed project is to construct a simulation model that will estimate production impact of disruption in swine marketing in Ontario, and propose mitigation strategies that could minimize impact of such disruption on swine populations and swine producers. Such disruption could occur due to various reasons such as outbreak of human disease among abattoir workers, or due to border closure that occurs due to hypothetical detection of reportable foreign animal disease in Canada.
Disengagement is not a “steady state” rather it is better conceptualized on a continuum with engagement in some areas as well as disengagement in others (Christenson and Thurlow 2004). The proposed research will explore how issues of access and equity factor into student engagement within the university setting. In particular, this research explicitly examines “push” and “pull” factors for engagement by drawing on several data sources to assess factors affecting retention rates and the experiences of students who leave post-secondary education.
Obstructive sleep apnea (OSA) is a common disease characterized by recurrent collapse of the airway during sleep leading to sleep fragmentation and daytime sleepiness. OSA is usually diagnosed based on an overnight sleep study (polysomnogram) which collects detailed physiologic information over the night. OSA patients are also at increased risk of cardiovascular disease such as heart attacks and strokes.
TRUSTSPHERE is a secure digital connection allowing patients to securely donate data and for researchers to ethically access patient’s data. The TRUSTSPHERE Consortium will create a links from mobile devices to providers, patients, and their families which will be tested and implemented to help with adopting this tool for management of children with Type 1 diabetes.
The anterior cruciate ligament (ACL), located in the knee, is commonly injured during sports. Patients who experience ACL tears often delay or choose to forgo surgery, which can reduce knee stability and alter movement patterns. Knee bracing is a commonly used treatment method to stabilize the knee. A novel method of knee bracing has been designed by Stoko to incorporate structural support in a supportive tight.
Ibrutinib has proven to be very effective in newly diagnosed and relapsed chronic lymphocytic leukemia (CLL) patients. However, it can cause certain side effects that can lead to early discontinuation of treatment and worse outcomes for patients. The goal of this study is to determine the frequency of side effects in the “real-world” associated with ibrutinib compared to standard therapy using provincial administrative data.
Injuries involving joint cartilage such as osteoarthritis (OA) are some of the most common causes of lameness and pain in equine. Sophisticated means of monitoring joint health status are needed to allow early detection and intervention as well as monitoring the effect of interventions. MicroRNAs (miRNAs), a class of short non-coding RNAs, participate in various biological processes including cartilage development and homeostasis. miRNAs have been measured at the tissue level, in synovial fluid and serum, and may reflect some aspects of the health status of the animal.
Rheumatoid arthritis (RA) is an autoimmune disease often characterized by the inflammation of the synovium and effusion of joints. RA is a chronic condition and may affect quality of life. Detection and characterization of the synovium and effusion in joints is most often assessed by a trained sonographer or radiologist. Recently ultrasound has been brought into the clinic and used by other trained healthcare professionals such as clinicians and physiotherapists.