Effectiveness of hypochlorous acid for eradicating coronavirus on hard surfaces

We are experiencing a health crisis in the form of a novel coronavirus - COVID-19. It has spread rapidly and overwhelmed many healthcare systems. Many health authorities and businesses have increased sanitization requirements including hospitals, nursing stations, long-term care facilities, shopping malls, grocery stores, and office towers. With this new solution we will be able to provide a product that can create more benefits and less harm to fight the pandemic.

Development of a serological test for early diagnosis and monitoring of cancer

Cancer is one of the leading causes of death worldwide. In Canada, cancer accounts for 30% of all deaths, and half of all Canadians will develop cancer in their lifetime. Many cancers can be prevented or controlled through early detection, but the availability of such tests is scarce and a reliable general biomarker for different types of cancers has not been yet discovered. Moreover, cancer survivors are at greater risk of developing a second cancer, and affordable and safe monitoring for the rest of their lives is not available.

Investigations into the mechanism of action and potential in idiopathic pulmonary fibrosis of the novel ruthenium based therapeutic BOLD-100

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease lung disease with unknown cause. There are limited treatment options for IPF and investigations into new treatment options is needed. BOLD-100 is a clinical-stage small molecule that is currently being investigated as a treatment option in oncology and viral infections. The pathway that BOLD-100 impacts, the unfolded protein response, is important in IPF and therefore this project’s objective is to use preclinical models to test whether BOLD-100 can affect development of IPF.

A Novel Bone Anabolic Treatment in Mouse Models of Pediatric Bone Fragility Disorders

Children that break their bones repeatedly often have genetic conditions that either affect bones directly or indirectly. The drugs that are currently used to decrease the number of fractures in children are only partially effective. Mesentech Inc. has developed a new drug that has shown a strong effect on bone formation in rats. In this project, we will test the effect of this drug in mouse models of a condition that affects bone directly (osteogenesis imperfecta) and a condition that affects bone indirectly (Duchenne Musclar Dystrophy).

Automated diagnosis of liver fibrosis and steatosis using deep-learning algorithms applied to conventional liver ultrasound

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver disorders worldwide. NAFLD could lead to end-stage liver disease and considered as one of the most common causes of liver transplantation. Moreover, a large number of liver transplant recipients develop NAFLD after transplantation due to side effects of the medications that they have to use to keep their new liver healthy. Although liver biopsy has been used for a long time to evaluate the liver condition it is associated with a risk of bleeding and other side effects.

Effect of Diesel Exhaust Exposures on the Respiratory Microbiome in COPD Airways

Some of the bacteria present in healthy lungs protect the lung against harmful germs. Studies have shown that people with lung diseases often lack these "good" bacteria in their lungs. Our team has been demonstrated that breathing polluted air causes lung inflammation, which can make it hard to breathe, especially for people who have lung diseases. We think that polluted air could change the lungs’ bacteria.

Effectiveness of Cannabis strains at reducing seizure rate in a zebrafish model of epilepsy

Cannabis has been used for centuries to treat epilepsy and related convulsive disorders. While Anecdotal evidence suggests a therapeutic benefit in some patients, there is little information as to what compounds within Cannabis plants may have medicinal benefits. This work will highlight specific strains (which CEPG will grow locally in Jackson’s Arm, NL) that will potentially provide effective seizure control in epileptic patients.

Follow up of horses treated with stem cells at eQcell Inc.

For over 10 years, eQcell Inc. has been treating horses with stem cells. In order to efficiently direct future research, a full picture of the efficacy of past treatments is necessary. This project will follow up with all clients across 8 clinics to collect an up-to-date snapshot of previously treated horses’ health and progression or regression from the time of treatment. These data will help generate hypotheses and narrow the research focus of the company to where stem cells may be best applied.

Effectiveness of an electronic technique and adherence monitoring device on the clinical outcomes of patients with asthma: an exploratory pilot randomized controlled trial

Mobile health (mHealth) strategies hold a great promise to enhance treatment outcomes while mitigating health care costs. It allows health care providers to tailor treatments to each individual based on their lifestyle. The primary objective of this project is to assess the effectiveness of the BreatheSuite Metered Dose Inhaler device in improving the technique and adherence of inhaled medications among children with asthma.

Supporting Evidence-Informed Practice and Policy Making in the British Columbia Community-Based Paediatric Rehabilitation Sector

Community- based Physiotherapy, Occupational Therapy, and Speech Therapy for children and youth with support needs is delivered by non-profit agencies across BC that do not have access to resources and supports to ensure they are providing evidence-based practice. This research project will help the partner organization, BCACDI, understand how it can implement a system to effectively support these agencies.