Analyzing the impact of the Lactobacillus rhamnosus R0011 secretome on intestinal epithelial cell and antigen-presenting cell interactions

Intestinal bacteria are now recognized as important for maintaining our health. Many questions remain about how these probiotic or health-promoting bacteria act to influence health, and how to use them to combat the numerous health problems associated with inflammation. The objectives of this research project are to determine how products made by one of these bacteria, Lactobacillus rhamnosus R0011, influence communication between certain cells important in our immune defences, intestinal epithelial cells and antigen-presenting cells. We have found that products of L.

Predicting recovery from concussion during military cadet training using multimodal MRI data and machine learning

In the military, concussions are common and many occur while non-deployed, including during cadet training exercises. For the majority of those with concussions, symptoms resolve on their own but for a “miserable minority” symptoms persist beyond the typical 3-month recovery period, impacting quality of life. Most concussion research produces group level inferences which cannot be used to make individual predictions. We propose a supervised machine learning approach to build a model to predict symptom recovery from multiple MRI brain measures.

Development of deep learning pipeline for automatic segmentation and classification of cardiac magnetic resonance images

Heart disease is the main reason of death worldwide. One way to understand better and detect heart diseases without need for biopsy via surgery is by using medical imaging such as magnetic resonance imaging (MRI). Cardiac magnetic resonance is a specific kind of MRI which allows great visualization of inner parts of the heart and can be used for measuring the size of the heart and its chambers, which can be very useful for understanding blood flow and other potential markers of disease.

Establishment of a Pressure Ulcer Biobank from Spinal Cord Injury Patients

Pressure ulcers (PUs) are a major health problem in people with spinal cord injuries (SCIs). PUs increase hospital admissions, with 25% of SCI treatment cost linked to PU management. Currently, treatment is limited and new therapeutic options are required. Wound fluid from PUs is invaluable for researchers as it allows a detailed study of the disease. However, no system is in place to systematically collect and store SCI PU wound fluid in British Columbia. In response, the aim of this proposal is to collaborate with the Rick Hansen Institute (RHI) to establish a PU biobank.

Development of a guideline of best police practices in locating lost persons with dementia

Three out of five Canadians with dementia wander, raising concern as to how it can be managed. Current information describing best practices to find missing persons living with dementia however, is inconsistent and can cause police difficulty in choosing search and rescue strategies for this population. The purpose of this project is to develop and promote the exchange of best practices to quickly find a lost person with dementia through the development of a guideline. It will involve a literature review and surveys with police across Ontario.

Advanced Data Science Research for Social Good II

Municipal governments and urban centres across Canada are being inundated with data—data that have potential to improve public service. Despite this, local governments do not have enough data expertise to extract insight from these overwhelming datasets. Simultaneously, high-quality personnel (HQP) in the domains of data science and urban analytics lack opportunities to work closely with local government to address this gap.

Exploring the Impact of Housing-based Overdose Prevention Interventions on People who use Drugs in Vancouver - Year two

Canada is amid an opioid epidemic, with governments declaring overdose public health emergency. Drug-related overdose mortality in British Columbia reached a record high in 2017, with over 1400 deaths. In response, novel overdose prevention interventions (OPI) have been implemented, including: overdose prevention sites in which people can inject drugs under supervision; and, naloxone training and distribution (a medication that blocks the effects of opioids during an overdose).

The Voices of Children and Youth: Community Injury Prevention through Visual Storytelling and Intervention (VOICES) in First Nations communities

The Voices research project aims to build injury prevention capacity within the First Nation community of Akwesasne (near Cornwall, ON) and among researchers.

Development of Coxsackievirus B3 as an Oncolytic Virus for KRAS-Mutant Lung Cancer Treatment

In Canada, lung cancer is the leading cause of cancer-related deaths for both sexes. Non-small-cell lung cancer (NSCLC) constitutes ~85% of lung cancer cases. Mutations in the KRAS and EGFR genes are two most common oncogenic drivers for NSCLC and responsible for ~30% and ~15% of NSCLCs, respectively. Unlike the EGFR-mutant type, KRAS-mutant NSCLC is currently undruggable and associated with poor prognosis. Our lab has recently demonstrated that Coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS-mutant NSCLC.

Development and trial of evaluative frameworks for inclusive employment programs

The Canadian Panel on Labour Market Opportunities for Persons with Disabilities (2012) found that 795,000 persons with disabilities in Canada are unemployed, even though their disabilities do not prevent them from working, and almost half have some form of post-secondary education. The exclusion of this section of the Canadian workforce is not only a key health and social issue, but also an economic and labour market one. Governments and private sector organizations have tried to address this disconnect in labour market engagement through a range of policies and supported employment programs.

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