Hearing aids are now fully digital, advanced signal processors. Studies show that the sound quality of todays hearing aids is important, and may impact how a hearing aid user enjoys music. Few tools are available for clinicians to measure hearing aid sound quality in daily practice. In this project, we will develop and implement a tool for this purpose.
As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that current chemotherapy protocols induce a very interesting phenomenon cellular senescence - in treated cells. Senescence is thought to be beneficial in cancer therapy under certain conditions.
In Canada, people with diabetes are 20x more likely to have an amputation of their lower limb than the general population. Having a diabetic foot ulcer (DFU) increases the risk of amputation by 50%. Early assessment and treatment of a patients DFU can prevent amputation, but patients with diabetes often lose sensation in their limbs, and may not even realize they have a DFU. There are currently no easily accessible early warning tools for DFUs. To address this need, we have invented a non-invasive device for DFU assessment, and are now optimizing it for use in patients at St.
A higher incidence of colon cancer is reported in populations consuming high amounts of red meat, as well as in patients with inflammatory bowel disease, where gut bacteria participate in the development of inflammation. We found that dietary supplementation with heme, an element found at high levels in blood, is detrimental to gut health and it fosters the growth of harmful bacteria. In this project, we propose to establish new procedures for both the manipulation of the gut bacteria (microbiota), as well as its characterization using a new state of the art sequencer.
Cancer arises as a result of deleterious aberrations in the DNA, RNA and proteins of cells. The accumulation of genetic abnormalities, over lifetime, perturbs critical functions of cells, which may ultimately give rise to tumor. However, vast majority of these aberrations are not essential and only small fractions, known as driver genes, are critical for tumor growth. Identification of driver aberrations is a challenging task, but is critical for optimal cancer management. Prostate cancer (PCa) is the most common cancer to affect Canadian men.
The Sam Sullivan Disability Foundation (SSDF) is a fundraising entity supporting six not-for-profit societies that provide opportunities for social engagement for people with disabilities. The six societies provide design opportunities for accessibility solutions; connect people with employment, training, and social opportunities in the community; and make sailing, music, gardening, and the great outdoors more accessible. This research project will look at the impact and effectiveness of the SSDF programming on the lives of people with disabilities.
Fasting blood samples from persons with Peripheral Arterial Disease (PAD) and healthy individuals were previously collected during a prior Mitacs project.
A comparative analysis of the blood samples by metabolomics will be performed to identify potential biomarkers.
The intern will assist with the necessary correlation analysis for selecting compounds capable of serving as blood biomarkers for PAD.
Koven expects to directly benefit from the outcome(s) of this research by having the opportunity to commercialize any promising blood biomarker(s) into a diagnostic kit for early diagnosis of PAD.
Alzheimers disease (AD) is a major challenge for the individual affected, society at large and there only modest effective drug treatment. We believe that a central problem in AD is the deteriorating fuel supply to the brain (mostly the sugar, glucose) and this impairment appears long before the onset of memory and cognitive problems emerge. We believe that attempting to correct this fuel problem will be part of any successful therapy for AD.
Mobile games have been dominating the Canadian video game industry over the past few years. However, the growing number of game releases creates an increased necessity to focus on quality in order to stick out of the mass. While storytelling has proven to greatly increase user
engagement in PC and console games, it is rarely used in mobile games. This creates an opportunity to explore if and how storytelling can be used in mobile games to achieve a similar effect.
Presently medical personnel do not have adequate tools to assess disorders of conscious awareness after severe brain injury if the patients have difficulty speaking & moving. These people are frequently deemed unresponsive when they may be in there" but unable to respond. Our research team has developed a rapidly administerable, portable system that measures brain waves in response to sounds & spoken sentences. Once diagnosis has been established, personnel are more equipped to make decisions regarding a patient's candidacy for rehabilitation.