The goal of this Mitacs research proposal study is to develop and apply experimental methodology for transdermal delivery of bone-targeting peptide hormone drugs. We aim to deliver these compounds using an appropriate hydrophilic-hydrophobic Diffusimax liposomal drug delivery cream base to anatomically superficial bone, at the sites of stress fractures (also known as shin-splints) in order to trigger bone repair, reduce pain burden, and to minimize possible side effects if those drugs were used systemically.
Egg yolk contains IgY antibodies that target various infectious disease and food allergens. IGY Inc is a company focused on utilizing chicken immune system for antibody production. IgY antibody contains 0.64% of total wet egg yolk, after cracking each egg IGY Inc generates 60-70g of liquid egg white which has a low commercial value. Egg white is a rich source of dietary protein and also known for its biological activities. Therefore the primary objective of this study is to develop a pragmatic technique to hydrolyze egg white to produce peptides with biological activity.
Pain in the craniofacial region is one of the more complex and difficult to treat conditions for patients and clinicians. Current treatments are complicated by limited efficacy and considerable side effects. Many of these conditions show greater prevalence in women than men, but there is a lack of basic research utilizing female animals. Recent advances
in cannabinoid pharmacology have renewed hope in cannabis-based treatments for chronic pain. However, whether the endocannabinoid system can be recruited to treat specific craniofacial pain conditions remains unclear.
Osteoarthritis is a slow and progressive degenerative joint disorder, and is the most common form of arthritis, causing a significant reduction in the quality of life of afflicted individuals. A common treatment for this disease is to inject corticosteroids, such as triamcinolone acetonide (TA), directly into affected joints, which treats the joint inflammation that causes pain, swelling and reduced mobility. However, the effect of these drugs is short lived due to the rapid clearance of the drug from the joint synovial fluid.
The work proposed here is based on a novel and innovative approach which has not been addressed till today. We propose that developing a combined therapy to inhibit ErbBs and activate SSTRs, might be useful approach to control tumor progression and better hormonal therapy response in breast cancer. The outcome of the present study first, will uncover novel molecular and cellular mechanisms for SSTR and ErbBs functional interaction in pathophysiological conditions such as in breast cancer.
Chicken egg yolk contains IgY antibodies that target various infectious disease and food allergens. IGY Inc is a company focused on utilizing chicken immune system for antibody production. Their innovative products have applications in food processing, therapeutics and diagnostics. IgY antibody contains 0.64% of total wet egg yolk and after extracting the antibodies, the leftover egg yolk is a material of low commercial value. Egg proteins are well known for its dietary value and also a rich source of bioactive peptides with anti-oxidant, anti-inflammatory activities.
Medical marijuana describes the legal use of cannabis plants for treating health-related issues. In Canada, there are currently about 40,000 medical marijuana users, and this number is expected to increase by over 1000% during the next decade. The large majority of patients use medical marijuana for its psychological effects, such as for anxiety, depression, pain and insomnia. There is a concerning lack of knowledge about the effects of different strains (“cultivars”) of medical marijuana, including both therapeutic effects as well as unwanted side-effects.
Cardiac arrhythmia is an electrical disturbance in the heart which can cause a variety of potentially life threatening conditions. Arrhythmias are due to malfunctions in the protein channels, which in turn alter the bioelectric currents signaling each heartbeat. A key channel responsible for terminating the electrical signal is the voltage gated potassium channel, IKs. During an adrenaline spike associated with the fight or flight response, there is an increase in IKs activity although the mechanism is not well understood.
Drug use in older persons is a major public health concern. Even though therapeutic drugs are beneficial for patients’ health in terms of survival or quality of life, patients aged >65 years have a greater risk of developing drug-related complications. Such complications may be fatal because of the high frequency of both multiple pathologies and polypharmacy in these patients, who consume a major proportion of healthcare resources.
Magnetic drug targeting is a recent drug delivery method where the drug is bound to a carrier, the magnetic nanoparticles. Directed with a magnetic field towards the target tissue, e.g., tumours. the drug is released there to produce a therapeutic effect. In many cases, however, it is additionally necessary that the drug enters the target cells to be active.