An Evaluation of Exercise Referral Schemes in Healthcare.

Greater physical activity and exercise is associated with better overall health and a reduced risk of many chronic conditions, but most of the Canadian population is insufficiently active. Physicians reach a large proportion of the population but experience barriers such as of time that prevent them from providing tailored exercise advice, as such they are interested in referring their patients to qualified exercise professionals or community exercise programs.

Pilot-scale preparation of phospholipid-free small unilamellar vesicle formulations with potential in treatment of hepatic diseases

Lipid-based nanoparticular drug formulations are a successful technique to enable targeted treatment. The Canadian company Precision Nanosystems Inc. (PNI) develops the innovative instrument family NanoAssemlr for lipid nanoparticle preparation based on microfluidics. These instruments are fast, easy-to-use and provide a high batch-to-batch reproducibility and quality. Recently, we developed a novel lipid nanoparticle formulation with the unique feature of selective liver targeting, which could only be prepared with NanoAssemlr Benchtop at relatively small scale.

Validation and Injury Risk Module Development for a Video-Based Physical Demands Description Tool

Benefit payments totaled 2.5 billion dollars for Ontario workplaces in 2015. The most common injury resulting in a lost time claim was a strain or sprain - indicating despite massive efforts to reduce musculoskeletal injuries by ergonomists, these issues still have a significant financial burden on the economy. An easy-to-use, readily available, and automated physical demands description (PDD) tool can allow worker health and safety professionals to evaluate worker injury risk with minimal training and expertise, and take steps to prevent or mitigate workplace injury risk.

Helmet testing and impact modeling: an approach to better understand the problematic of concussion in short track speed skating

The sport of short track speed skating is an extremely fast paced sport, in which multiple skaters, reaching speeds upwards of 50 km/h, jockey for position on a narrow track. Although skaters wear protective equipment and helmets, concussions continue to plague the health of athletes. Currently, there are no statistics on the ratesand prevalence of concussion in short track speed skaters.

Improving Caregiver Mental Health with the Use of a Smartphone App

Many of those dealing with anxiety and/or depression are frequently in the care of a friend, partner, or family member known as an informal caregiver. This important role can be very taxing both physically and psychologically, yet few resources are available to specifically target individual caregivers’ needs. The proposed project will contribute to our understanding of caregivers’ experiences as well as evaluating care’n, a smartphone application designed to support informal caregivers’ wellbeing.

A preclinical study evaluating INOLIFE’s needle-free injection system (INOJEX) with cannabidiol (CBD) for the treatment of neuropathic pain and associated anxiety-depressive symptoms in rats.

Chronic neuropathic pain affects millions of Canadians for which the government spends ~$6 billion a year on treatment. It is therefore imperative to find new therapies with few side effects and high therapeutic efficacy. This study will examine the therapeutic properties of cannabidiol (CBD), which is a non-intoxicating component of cannabis. Studies have shown that CBD has ant-inflammatory, anti-anxiety, and pain-relieving effects.

PET/MRI Imaging Development for Pre-clinical Neuroimaging Applications

The field of nuclear medicine relies on positron emission tomography (PET) and single photon emission computed tomography (SPECT) scanners to visualize molecular processes in normal and disease states in the living human.

Air Ambulance and Pre-Hospital Emergency Care in Northern Labrador: An Evidence Mobilization Project

In rural regions of Canada, many patients live far from hospital emergency departments and specialty services. When urgent medical care is required due to a health crisis, access to pre-hospital care and the distance to an emergency department can have a major impact on morbidity and mortality. The primary objective of our study is to examine demographic patterns and clinical characteristics of medevac service use in the northern Newfoundland and coastal Labrador region accompanied by a strong knowledge mobilization plan.

Development of Coxsackievirus B3 as an Oncolytic Virus for KRAS-Mutant Lung Cancer Treatment

In Canada, lung cancer is the leading cause of cancer-related deaths for both sexes. Non-small-cell lung cancer (NSCLC) constitutes ~85% of lung cancer cases. Mutations in the KRAS and EGFR genes are two most common oncogenic drivers for NSCLC and responsible for ~30% and ~15% of NSCLCs, respectively. Unlike the EGFR-mutant type, KRAS-mutant NSCLC is currently undruggable and associated with poor prognosis. Our lab has recently demonstrated that Coxsackievirus B3 (CVB3) is a potent oncolytic virus against KRAS-mutant NSCLC.

Strategies to attack cancers

Pascal Biosciences Inc. is a company developing immuno-oncology therapeutics to fight cancer. It was initially founded on ideas and research that originated from Dr. Wilf Jefferies’ laboratory at the University of British Columbia. Since then, the company has continued to collaborate with Dr. Jefferies and his team to forward the research, through direct sponsorship and through collaborative research partnerships. Pascal has a mandate to discover and develop targeted agents that enable the body's own immune system to recognize and attack cancers.

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