Parallel Radiofrequency Transmission Technology for Magnetic Resonance Imaging at 3 Tesla - Year two

Funds are requested for one fellow to work in the laboratory of Dr. Simon Graham at Sunnybrook Research Institute, Toronto, in partnership with Siemens Healthcare Limited. The fellow will work on development of prototype instrumentation that will enable a technique called "parallel radiofrequency transmission (PTX)” to be implemented flexibly for research purposes on a Siemens 3 T MRI system at the Institute.

Development of a clinical protocol for the validation of a detection test for ??amyloid aggregates in retinal scan images.

Alzheimer’s disease (AD) is a neurodegenerative disorder that is difficult to detect early before apparent manifestations of cognitive decline. Current detection methods rely on expensive and hardly accessible imaging techniques (PET scans). Optina Diagnostics developed a new camera as well as innovative image processing methods to propose a non-invasive test to identify the presence of AD biomarkers in evaluated individuals. The objective of this collaborative effort is to develop a clinical protocol to test this new technology.

Securing Accessible, Quality Early Learning and Care for Families Working Non-Standard Hours in Alberta: A Systematic Scoping Review

Across Canada, many families struggle to find high quality, affordable child care. Most child care options for families are limited to daytime and weekday work hours; this creates even greater challenges for shiftworkers who rely on paid child care. When child care is not available, mothers usually bear the greatest burden as many women, whether parenting alone or with a partner, act as the default primary caregiver.

Scaling 3D Microtissue Production Using a Microwell System

Tissue engineering works to replace damaged tissue and organs, and has applications in treating diseases such as diabetes. To improve the performance of tissue engineering treatment and research, our lab has produced the microwell system which creates microtissues in the form of cellular balls. The microwell system has been used used internationally under the brand name AggreWell™, supplied by STEMCELL Technologies and allows researchers to produce enough microtissues to treat diseases in animal models, such as mice.

The effect of phyto-cannabinoids on osteoclast differentiation and function

The recent legalization of marijuana in Canada opens the opportunity to study in detail the effects of cannabinoids on human physiology. This academic-industry initiative will combine resources to isolate compounds from cannabinoids to study their effects on bone cells. Specifically it will examine the effects of cannabinoid compounds on how the destructive osteoclasts form and act upon the bone in vitro. This cell culture work will pave the way for future clinical studies. Bone-wasting disorders like osteoporosis are a major economic burden and inflict a large population of the elderly.

Digital speech analysis: prediction and differential diagnosis of PTSD symptoms and severity

Occupational stress conveys risk of Posttraumatic Stress Disorder (PTSD).

Machine Learning Modeling for Autism Spectrum Disorder Handling and Treatment

The project is about developing a decision support tool to provide a personalized handling and treatment for Autistic Syndrome Disorder patients. This decision support tool will integrate machine learning modeling that will be used to suggest optimal and personalized guidelines for a very large spectrum of ASD patients, not available so far. Theses guidelines will be used by concerned parents, teachers and therapist that are in charge of these patients. The partner is a company that offer accompanying and training services to ASD patients’ parents and therapists.

Sex: It’s a matter of the heart

Heart failure is a complex cardiovascular disease with increasing global burden while the prognosis for patients remains poor. Risk factors and the type of heart failure differ between men and women. These differences can be due to sex – referring to biological differences – or gender – referring to social differences. In our project we will study the role of genetics in the different types of heart failure in men and women, using models that distinguish the contribution of both sex and gender.

Preference analyses and development of an e-health app facilitating communication of test results for hereditary cancer syndromes

An estimated 5-10% of cancers are inherited through family members. To identify patients’ risk for developing hereditary cancers, genetic testing can be used. Communicating hereditary cancer genetic results to patients is challenging for health care practitioners. Practitioners want to ensure that patients understand and communicate their preferences for receiving information. Tools to aid patients in communicating their preferences need to be developed.

Salivary insulin profiles throughout the day in humans with elevated waist circumference

The hormone insulin rises in the blood after consuming food. Too high of an insulin response may be a sign of dysfunctional metabolism and has also been shown to promote weight gain. Thus, if insulin levels rise too high after a meal it may indicate that someone is metabolically unhealthy or is prone to obesity. Currently insulin is only measured in research studies using blood samples and costly, time consuming measurement techniques. This project aims to determine if saliva can be used to measure insulin in order to allow for non-invasive insulin measurement.

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