Visual enhancement in normal and abnormal visual system

Vision loss related to malfunctioning of the brain have always been believed to be unrecoverable in adults. Novel treatments, however, have shown the opposite. Visual stimulation is a computer-based system which devised visual stimuli are presented to participants. Transcranial Magnetic Stimulation is a non-invasive technique to deliver an electric current to the brain. Both treatments have shown promising results on recovering vision in participants with amblyopia (lazy eye) and in the ones who lost it following a stroke. We will study the benefits of combining these two techniques.

Integration of smart sensing fabric in a DVT pressure stocking

Deep vein thrombosis (DVT), formation of blood clot in deep vein usually in leg, has severe health complications that can lead to disability or death. Applying a cyclic pressure can improve blood circulation and may prevent DVT. This cyclic pressure can be implemented via mobile compression socks (MCS). However, MCS only apply static pressure, which reduces the effectiveness of the MSC. The Toyo team has developed and patented a compression stocking capable of applying cyclic pressure.

Development and Analysis of Electric-Assist Wheelchair Systems

A power-assisted wheelchair is a hybrid between manual and power wheelchairs that consists of an electric-assist system that can be easily mounted on a manual wheelchair. The market for power-assisted wheelchair systems has seen growth in the past decade because of their benefits on the health and mobility of manual wheelchairs users. However, current power-assisted wheelchair systems are not fully addressing user requirements. The proposed research project involves analyzing the mechanical and subjective characteristics of currently available electric-assist systems.

Characterization and optimization of a multi-phase aerated stirred fermenter using experimental and computational techniques

Multi-phase aerated stirred fermenters are well-accepted in the production of biopharmaceuticals including antibodies and vaccines. Nevertheless, their hydrodynamic and mixing characteristics as well as the influence of various process engineering variables on their performance are not fully understood. In the current study, extensive experimentation (ERT and endoscopy) and the Computational Fluid Dynamics (CFD) approach will be employed to gain deep insights into the underlying phenomena happening in aerated stirred fermenter.

Improving the use of evidence-informed health policy for individuals with brain-based disabilities

There has been an increasing focus in the health and disabilities research field on knowledge translation – that is, to ensure that emerging research can be effectively integrated into health and social service policies and into service delivery. Studies on the development of policy and services demonstrate that many factors apart from academic research evidence play significant roles in creating services and policies. In fact, evidence and/or best practices that some might argue is irrefutable, may never make its way into policy or practice.

A Novel Combination Therapy to Target Primitive Acute Myeloid Leukemia Cells

Modern molecular targeted therapies have shown promise in treating some blood cancers, but a cure remains elusive for most acute leukemia patients. This is largely due to the survival of some leukemic cells that possess unique properties and can cause treatment failure or relapse, warranting identification of new, distinct targets for improved therapies. In collaboration with Signalchem Lifescience Corporation (SLC), we aim to develop and test a new drug combination strategy to target acute myeloid leukemia (AML) patient cells that are resistant to current therapies.

Mechanisms of the relationship between ageing and dementia.

As our population ages, the burden of dementia is growing. Alzheimer's disease (AD) is the most common cause of dementia; currently we do not have any disease-modifying treatments for AD. There is motivation to better understand the mechanisms of AD development and expression to control the burden of disease.

Frailty is related to neuropathological features of AD (i.e. plaques and tangles) and clinical dementia. Frailty and AD-type dementia share many risk factors and clinical features.

Development of a SEMA3C targeted therapeutic for treatment of clear cell renal cell carcinoma, lung cancer, breast cancer and colorectal cancer

The major focus of this proposal is to perform preclinical studies to support clinical development of a novel inhibitor for treatment of different caners such as breast, lung, colorectal and kidney. We have recently developed a novel therapeutic protein that selectively inhibits multiple pathways for treatment of advanced prostate cancer.

Development of a novel stem cell-seeded extracellular matrix for treatment of chronic wounds

The bedsore or pressure ulcer is a serious health problem that affects many individuals with spinal cord injury (SCI). These ulcers mostly develop on skin that covers bony prominences of the body, such as the hips and tailbone. Pressure ulcers are often very difficult to treat and not only negatively affect patients’ health, but also have profound impact on their quality of life. This speaks to the need for finding more effective treatment methods to address this problem. Our aim in this research project is to find a novel method to improve the healing of pressure ulcers.

A Pilot Clinical Study of Treating Pressure Ulcers in patients with Spinal Cord Injury

Pressure ulcers are among the top five leading causes of re-hospitalization in patients with spinal cord injuries (SCI). Unfortunately, current conventional prevention and treatment methods have neither decreased the prevalence of these ulcers nor significantly improved their outcomes. To address this difficulty, here, we will test the efficacy of our new liquid skin substitute to fill up the non-healing wounds where the skin solidified and promotes the healing process. Our plan in a pilot study is to treat 12 patients who pressure non-healing wounds did not heal in the previous 3 months.