Knowledge Recombination and Alliance Strategy in Science-based Businesses

Project Objectives:

1. To identify the best practices in knowledge recombination by comparing science-based multinational corporations and start-up firms.

2. To suggest refinements in alliance strategies for science-based multinational corporations and start-up firms.

3. To uncover processes and organizational structures to productively exploit the confluence of biotechnology and nanotechnology by MNCs.

Post Doctoral Fellow Name: Dr. Varkey Jon Thomas

An evaluation of geohazards arising from gas hydrate dissociation in Canadian continentalmargins

The long-term research goal of the research group is to contribute to the fundamental state-of-knowledge on gas hydrates by improving methodologies and techniques for characterization, assessment, and development of natural gas hydrate accumulations. The short-term goal and main objective of the present proposal is to characterize and assess submarine geohazards evolving from gas hydrate instability.

Investigating the biophysics and structural basis for state dependent drug blockade of persistent/late sodium current (INa(P)) in the heart using photoactivatable crosslinking unnatural amino acids.

Electrical activity in the heart is controlled by the concerted activity of many proteins called ion-channels that regulate the transfer of different ions across cell membranes. Recently, researchers in biomedical science have identified that a particular component of sodium carrying ion-channel activity (called the persistent or late sodium current also known as (INa(P)) played a major role in controlling the electrical activity of the heart. More recent research suggests that this late sodium current may be involved in various cardiac diseases.

Determining the half-life of prophylaxis treatment using population pharmacokinetics

Hemophilia is a rare blood coagulation disorder caused by a deficiency or deformity in one of 12 primary clotting factors. Hemophiliacs experience insufficient healing and prolonged bleeding either from trauma or unprompted bleeding. We are able to maintain a level of the deficient factors in a patient through direct and immediate infusion of a drug into the blood. To determine the frequency of injections and the appropriate dosage, we need to consider how long a drug will stay in a child’s body.

Antineoplastic evaluation of novel 3,5-bis(benzylidene)-4-piperidones

The principal objective of this proposal is to discover novel drugs to treat colon cancers. Currently colon cancer is a huge medical problem and there are many disadvantages to current drug therapies. These disadvantages include their ineffectiveness to completely eradicate cancers, causing toxic side effects and the development of multidrug resistance. A group of compounds discovered in the laboratory of the supervisor designated series 2 has significant potencies towards a number of human colon cancer cell lines.

Pharmaceutical development of a thermo-sensitive polymer for intrabladder delivery

Targeted delivery of drugs can reduce the side effects associated with oral delivery systems. The urethra provides easy access of therapeutic agents to the urinary bladder, an ideal organ for localized therapy for the treatment of bladder cancer, interstitial cystitis, overactive bladder, and chronic prostatitis. We propose a new therapeutic approach to increase the residency time and efficacy of the drugs by using biogradable polymers as a drug carrier, allowing a prolonged release of drugs in the bladder.

Development of Climate and Infrastructure Forensic Analysis Systems: A BayesianPerspective

This project will upgrade the Climate and Infrastructure Forensic Analysis System (CIFAS), originally developed to characterize snow- and permafrost-related impacts to ground transportation and mine access roads in the Canadian North. My first objective is to enhance the analytical capacity of CIFAS by improving its ability to quantify uncertainties associated with empirical knowledge used to causally connect infrastructure service levels with climate-induced disturbances, as well as with climate projections from climate models.

Visualisation et quantification des ROS et de l’apoptose dans des microtumeurs 3D

L’objectif du projet est de mettre au point des méthodes de visualisation par microscopie confocale laser l’intensité du stress oxydant ainsi que les zones d’induction d’apoptose dans des cellules cancéreuses perméabilisées. Les cellules cancéreuses qui seront étudiées sont des cellules de carcinome colorectal humaines de la lignée HCT116 provenant de American Type Culture Collection.

Cardiovascular function, inflammation, and exercise: potential role of anti inflammatory supplementation to optimize health and performance

Additional research is required to fully understand the effects of a powerful antioxidant Curcumin on the short and long term impact of exercise. Previous studies have demonstrated other antioxidants can potentially slow recovery and reduce benefits of exercise. However, there is lacking information regarding the effects of Curcumin on cardiovascular health and exercise performance.

DEVELOPMENT OF ROTATIONAL THROMBOELASTOMETRY (TEM) BASED TRANSFUSION GUIDELINES FOR THE OPTIMAL MANAGEMENT OF EARLY RESUSCITATION OF BLEEDING TRAUMA PATIENTS

Bleeding following traumatic injury is the leading cause of early cause of death. Currently these patients are treated based on the results of time consuming laboratory tests resulting in inappropriate usage of blood products and poor survival rates. Rapid recognition of defects in clotting mechanism is necessary to stop bleeding in trauma patients.

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