Cancer arises as a result of deleterious aberrations in the DNA, RNA and proteins of cells. The accumulation of genetic abnormalities, over lifetime, perturbs critical functions of cells, which may ultimately give rise to tumor. However, vast majority of these aberrations are not essential and only small fractions, known as driver genes, are critical for tumor growth. Identification of driver aberrations is a challenging task, but is critical for optimal cancer management. Prostate cancer (PCa) is the most common cancer to affect Canadian men.