Cytology-based DNA measurement for oral cancer screening

Oral cancer (OC) presents a global burden on society and the healthcare system with high incidence rates and poor prognosis. Despite the oral cavity being easily accessible for visual assessment, lesions are often detected at an advanced stage when the prognosis is poor and radical interventions are necessary. An invasive biopsy of a clinically suspicious lesion is the current standard of care for OC diagnosis and lesion monitoring; however, repeated biopsies may not be feasible.

Betulinic acid derivatives as a new agents for pediatric cancers

The aim of the project is to design and test different chemical derivatives of betulinic acid as a treatment for cancer. It is well known that betulinic acid is able to specifically kill cancer cells, and so we have developed several derivatives to improve biochemical properties such as solubility or biodistribution but maintaining the toxicity for cancer cells. We will test these different chemical structures on different cell lines (normal and cancerous) and try to elucidate the mechanism of action of those compounds.

The development of nanoparticle-doped redox active hole transport materials for next-generation solar cell cathodes

Koivisto Materials Consulting Inc (KMC) is a Canadian-owned and operated for-profit company that seeks to commercialize a low-cost optically transparent photovoltaic windows and coatings. KMCs proprietary technology is based on a modified dye-sensitized solar cell (DSSC) architecture and novel bio-inspired dyes. The two major advantages for DSSC devices are their optical transparency and ability to operate more effectively in diffuse light conditions (cloudy days, indirect sunlight, etc.); making them amenable for urban landscapes and all interior surfaces.

Advanced non-destructive testing solutions for mass concrete and deepfoundations

This project aims to develop an improved methodology for condition assessment of mass concrete structures and deep foundations using customized NDT solutions and an integrated approach. The project builds on recent advances developed by the project partner (FPrimeC Solutions) and the academic research group (uOttawa) for next-generation NDT products and services. Assessing the condition of large foundations and other mass concrete structures is complex, yet critical for the protection and maintenance of valuable infrastructure assets.

Verification methodologies for autonomous agents to enable safe marine autonomous surface ships (MASS)

The application of autonomy is driven by a desire to safeguard lives by removing crew from dangerous environments and reducing the likelihood or impact of accidents arising from human error. State of the art Marine Autonomous Surface Ships (MASS) deployed for extended periods in complex in-land, coastal, and off-shore applications, must be able to address changes in their state, environment, and mission by adapting their mission plan.

Targeting SARS-CoV-2 (COVID-19) methyltransferases (nsp14 and nsp10-nsp16 complex) toward developing small molecule antiviral therapeutics - Part 2

COVID-19 pandemic has brought the world to standstill with more than 55 million people infected to-date and more than 1.34 million mortality so far. It has literally brought the health care systems in many countries to the breaking point, if not beyond. The economic consequences have been devastating with millions of people out of work. We are taking a novel approach by focusing on two SARS-CoV2 (COVID-19) methyltransferases that are essential for viral replication. Both enzymes (nsp14 and nsp16) are druggable.

Development of a software module for integrity analysis of subsea pipelines facing ice-induced geohazards

The Arctic Region is considered an extreme environment for natural resources extraction. One potential threat to an Offshore Pipeline is the constant movement of ice based structures, such as icebergs and ice ridges. The project is focused on developing a numerical methodology to simulate the effects of ice gouging/ ice scouring on buried pipelines. The developed tool will incorporate all the latest advances in terms of soil properties and sophisticated interactions modeling between ice, soil and pipeline.

Detoxification of oil sands process-affected water

Alberta’s oil sands tailings ponds contain approximately one billion m3of oil sands process-affected water (OSPW). This water is toxic and must be treated in order to comply with environmental regulations. In this project, Metabolik’s team will conduct two sequential field trials in small, contained environments, where they will identify, and assess the impact of the key environmental parameters such as dissolved oxygen, pH, osmolarity and temperature on the ability of the strains to degrade the toxins in tailings pond water.

Moisture accumulation in a cavity-insulated thick-wall assembly with an exterior air barrier system as a result of natural convection in cold climates

The intent of the proposed research project is to measure the performance of a highly-insulated wall assembly system when an exterior air barrier system is used and air movement within and across the wall occurs. In cold climates, the movement of warm, moist air within and across an exterior wall may result in moisture accumulating on some of the surfaces within the wall if the conditions allow, causing long-term damage if it does not dry out.

Ozone Disinfection of Commercial Goods at Global Scale

This project investigates the possible use of the oxygen coproduct from electrolytic hydrogen production, as a feed to produce ozone for disinfection purposes. The shift to a hydrogen economy will see a significant increase in the amount of oxygen produced, and currently, this oxygen has no use. It is possible to capture the oxygen, and to convert oxygen to ozone. The technological challenge is to determine the limits for safe operation of the ozone disinfection processes. This project will scope the this concept with the proposed application of sterilization in a distribution warehouse.