Innovative hybrid carbohydrate and lipid-based nanomedicines for gene delivery

Genes are input signals that command the cell to synthesize specific proteins to have the specific cellular functions as outputs. Thus, by adjusting the gene expression, desire/unwanted cellular function can be added/eliminated. Gene therapy acquired significant attention as it relies on using exogenous nucleic acid to add/regulate specific gene expression thus this novel therapy possesses tremendous potential to be used in cancer management, treating hereditary diseases, and vaccines.

Development of high protein canola using MAD7 gene editing

This project targets the improvement of seed protein content in Canola seed using genome editing. The development of high protein content in canola seeds has potential to be utilized in the production of plant protein ingredients and as a source of high protein feed in the dairy and aquaculture industry. AgGene, the partner organization is an Alberta-based startup company and will benefit from MITACS support to hire a high quality intern to facilitate the development of high protein canola by leading the transformation and identification of gene edited canola plants.

Designing Next Generation Clinical Trial Recommendation System

While numerous reports have depicted positive experiences leveraging Electronic Health Record (EHR) information to facilitate clinical trial recruitment, matching and eligibility screening (ES) is still conducted manually in most cases. Manual ES usually involves an extensive examination of patient records and trial criteria descriptions, a challenging and laborious process that creates a significant financial burden for any healthcare facility.

An Activity Theory-Based Project Management Tool For Agile

This project will apply the theoretical framework of Activity Theory to Agile product development methods in order to decompose them into salient components, using an integrative literature review of Agile methodologies to do so. This decomposition will then be used to adapt the open-source education management/planning software CourseFlow for use in Agile development. This software has been designed with Activity Theory in mind, viewing different levels of education (lesson, course, curriculum) as interconnected and nested activities.

Modelling Investigation of Arsenic Contamination in Drinking Water

This project supports comprehensive investigation of arsenic contamination in the aquatic ecosystems in Canada. The project aims to provide a framework/guideline to predict probability arsenic contamination in different area. This will be through appling AI and ML modelling approaches by considering geo-environment and hydrochemical predictor variables. The MITACS support will be used to hire a research assistant to support the activities envisaged in the project. The researcher will be supporting computational modelling at Memorial University (MUN).

A framework for assessing qualitative and quantitative risks of installing and operating water supply services in small, remote Indigenous communities

Water infrastructure and supply service in Canadian small, remote Indigenous (SRI) communities are facing various challenges, including long-term water quality advisories. A water infrastructure risk assessment system is much needed to help identify critical nodes that are prone to cause failure in the entire water supply service chain, ranging from pre-project planning to water service operation. In the proposed study, a comprehensive framework will be developed to assess various types of risks in water infrastructure project development and water supply service in SRI communities.

A Deep Learning Guided End-to-End Electromagnetic Metasurface Design Framework

Electromagnetic metasurfaces have shown great potential in the field of antenna design thanks to their abilitiesto systematically manipulate electromagnetic waves in extraordinary ways such as the generalized refraction andreflection, impedance matching, polarization control, etc. However, the synthesis of a metasurface based on therequired scattering properties still largely relies on the designer’s intuition and experience as well as manyiterations of full-wave electromagnetic simulations which is an expensive and time-consuming process.

Lake Kivu Degasification Reservoir Engineering Study

Lake Kivu is a unique lake with a significant amount of methane and CO2 dissolved in its deep layer. The presence of these greenhouse gases poses a potential danger of massive disaster. The extraction of methane is viewed as a possible and profitable solution as the reduction of methane will enhance the ability of the lake water to absorb more incoming CO2, consequently reducing the risk of uncontrolled gas eruption. The safe extraction of methane requires comprehensive study about the transport processes involved with the production of methane and reinjection of degassed water into the lake.

Co-construction of the lower Wolastoq-St. John River Climate Adaptation Plan

This applied research project addresses the question of regional adaptation planning to impacts of climate change and extreme weather events in the rural lower Wolastoq-Saint-John River region. It is piloted by the non-profit Voices for Sustainable Environments and Communities and supported by the Universities of Waterloo, Téluq and Moncton. Two municipalities and nine local service districts (LSD) are involved in the project. The study region experienced significant flood events in 2018 and 2019.

Development and validation of BRET-based biosensors for drug discovery

G protein-coupled receptors (GPCRs) are the most abundant signaling proteins that respond to a wide variety of stimuli such as light, neurotransmitters, lipids, hormonal peptides, proteins, extracellular calcium, proteases and other molecules. By their localization in cell membranes, they mostly act at the interface between the extracellular and intracellular milieu although they also have functions on distinct intracellular organelles.