Engineered Polymers for Nucleic Acid Therapies

Nucleic acids such as DNA and RNA offer exceptional opportunities to fight against infectious and genetic diseases. To use nucleic acids effectively in a clinical setting, one needs to use effective delivery vehicles that can deliver the nucleic acids into the diseased cells. This project will develop effective delivery systems for this purpose. The delivery systems will be used to deliver RNA and DNA based therapeutic agents in 2 diseases, namely Coronavirus disease 2019 (COVID-19) and hematological cancers.

Teaching Forests as Living Museums: Case Study Research for Innovative Practices that Further National, Community, and Environmental Sustainability

Innovation and change are critical in the management of environmental, social, and economic stewardship. Developing avenues for effective innovation growth is a worthy objective. This research examines the potential for innovation surrounding Teaching Forests in the Northern Hemisphere. Through evaluative and exploratory research, an inductive approach is taken using tools of survey and interview of key Teaching Forest Managers to create new knowledge on this topic.

Investigating social-ecological enabling conditions for the revitalization of Indigenous clam management systems in an urban context

The general objective of the proposed activity is to increase the future productivity of Burrard Inlet and the contribution of seafood to the diet of Tsleil-Waututh Nation (TWN) members in support of the TWN Cumulative Effects Monitoring Initiative.

Germicidal Robotic Systems

Coronavirus is highly contagious. It can remain active and infectious on cardboard, fabric, and paper for up to 24 hours, on plastic, stainless steel, and countertops for up to three days. Decontamination, sterilization, and disinfection are standard procedures to prevent and reduce the spreads of COVID-19.

Distributed traffic management system for future urban mobility

As a solution to reduce congestion on vehicular roads and mitigate longer travelling times, this technology provides the most optimal routes for drivers by guaranteeing the shortest travel time in an eco-friendly environment. The technology relies on communication to road-side intelligent intersection agents with embedded sensors that to estimate routes based on the real-time road link traffic status. The system is capable to distribute traffic in an efficient manner to control and coordinate vehicular movements.

Magnetic resonance imaging (MRI) thermometry

We are creating a powerful tool for improvements in surgeries of the brain and spine. A new magnetic resonance imaging (MRI) machine will be used inside operating rooms so patients undergoing surgery can be imaged in the middle of the surgery for quality control. For instance, surgeons can obtain an MRI to ensure the entire tumor was removed before ending the surgery. Beyond surgery, low field MRI has many exciting applications to improve treatment options. A technique called MR thermometry can map the temperatures of tissues inside the body.

Wearable Ultrasound Technology for Cardiovascular Health Monitoring

The proposed research concerns the construction of a computer simulation environment for the artery phantom with cardiac cycles and ultrasound signals obtained using our novel wearable ultrasound sensor (WUS) technology when monitoring the cardiovascular health. It is difficult to assess health indicators of the artery of a living subject experimentally for comparison with those estimated using our WUS and associated software.

Discovering causal variants controlling ripening period, phenolic content and softening during storage in apple (Malus domestica).

Apples are among Canada's most valuable fruit crops, and the improvement of apple varieties is crucial for the success of the industry. Breeding apples is expensive and time consuming, requiring decades of investment. A better understanding of the relationship between genetics and fruit traits will allow for more efficient breeding. Current apple breeding techniques make use of genetic markers, but these markers are of limited use.

Development of a textile-based sensor for measuring body fluid

Heart failure (HF) is the third most common reason for hospitalization in Canada, where, the direct health care costs of HF are $2.8 billion. HF affects 600,000 Canadians with median survival of only 1.5 years after diagnosis. HF patients stay longer at hospital. Even after discharge, 1 out of 5 of patients returns to the hospital within a month. The major complaint of HF patients is shortness of breath due to extra water in their body and lungs. Thus, monitoring of body water is an important challenge in HF, especially at home settings.

Development and preclinical evaluation of R-Sulforaphane-based therapeutics in treatment of chronic kidney disease

R-Sulforaphane (R-SFN) is a naturally occurring phytochemical that can be found in most of cruciferous vegetables, such as broccoli and kale. R-SFN has been shown in many research studies holding therapeutic promise for many chronic diseases. We propose to develop more advanced methodologies to product, purify and formulate R-SFN. We also propose to evaluate the therapeutic effect and safety profile of R-SFN in treating chronic kidney disease (CKD) in a rat model.

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