Application development for use of “CLiC” single-molecule imaging in pharmaceutical sciences

In this project, the interns will develop a new set of tools and techniques to provide new scientific insights into the detailed interactions that occur between drug and target molecules in the human body. Understanding of these interactions is critical to design better, more effective, and more precisely targeted drugs. The problem is that current techniques for investigating molecular interactions make “ensemble measurements” over huge numbers of drug and target molecules and give researchers only an “average” measurement of the interactions.

Chronotype-based recommendations for shift workers to improve sleep and work performance

During night shifts, workers’ circadian rhythms (or “body clocks”) do not align with their work schedules. This misalignment results in poorer sleep and more workplace errors relative to working during the day. It is possible to align the body clock to night shift schedules by controlling one’s exposure to light. However, the effectiveness of this approach may vary depending on people’s work schedules (e.g., rotating or permanent night shifts) and chronotype (i.e., their biological preference for usual sleep and wake times).

Wind Field Estimation, Exploitation and Guidance for Unmanned Aerial Vehicles

Unmanned aerial vehicles (UAVs) have become increasingly used in the fields of data collection, surveillance, and search and rescue missions. For many UAVs, knowledge of the instantaneous wind speed and direction and overall wind field are of interest, as this knowledge can help better control the position and orientation of the UAV in heavy wind. In addition, knowledge of the wind field can be used to prolong flight times and improve the efficiency of flight of the UAV, by planning paths for the UAV to follow that exploit the wind and harvest energy from it.

Establish relationship between productivity and raw material properties to control of a Ferrosilicon furnace

This project will investigate the efficiency of the ferrosilicon smelting process by determining electrical resistance of the raw materials. Ferrosilicon is produced in a submerged-arc furnace, and requires large amounts of electrical energy. The process requires quartz, iron, and carbon as the raw materials. Each of the three input materials have different electrical properties that determine the electrical resistance and therefore efficiency of the furnace.

An investigation of the occlusive properties of smart polymeric particles usingquantitative image analysis of dentin microtubules

Many young adults are affected by tooth sensitivity stimulated by eating or drinking something hot, cold, sweet or acidic, which impacts their life quality. Tooth sensitivity can start when the softer, inner part of the tooth called dentin becomes exposed. The dentin contains a large number of parallel microtubules that run from the outside of the tooth to the nerve in the center. When it is exposed, these microtubules can be stimulated by changes in temperature or certain foods resulting in the sharp pain.

Development of a microfluidic point-of-care diagnostic device for the discrimination between viral and bacterial infections as a means to reduce antibiotic resistance

The discrimination between viral and bacterial infections has long been a goal in the field of point-of-care (PoC) diagnostics. Such a diagnostic tool would prevent the over-prescription of antibiotics, a leading cause of antimicrobial resistance. Current standard methods involve sending patient samples (throat swabs, blood, urine) to specialized clinical labs. This usually involves expensive and time-consuming protein biomarker assays to identify the cause of infection.

Understanding Montreal festival soundscapes

Quartier des spectacles is a dense multi-cultural hub with large outdoor festivals, also housing an ever-growing residential population due to new high-rise development projects. Given the need to balance vitality with quality of life, this project focuses on expectations of residents and festivalgoers in terms of their sound environment.

Hard Anodising of A205 Aluminum Alloy

The future of aerospace technology relies on us investing in lighter, more fuel-efficient materials that can operate at hotter temperature with greater corrosion resistance. One such alloy that has the potential to meet these needs is the new aluminum alloy A205. In this work we aim to develop a hard anodising process for the A205 alloy, enabling it to perform in more demanding environments. The hard anodising surface treatment will combine corrosion resistance with wear resistance opening up new avenues of applications for the A205 material.

Increasing winter wheat selection efficiency via genomic selection

Winter wheat is crop that is growing in popularity in Quebec, as it produces more grain per hectare than spring-planted wheat and has many positive effects on soil health. However, many of the varieties used by farmers are not actually bred for this region, and are often maladapted to the local environment. The Center for Grain Research of Quebec (CEROM) is dedicated to bringing new, better varieties of winter wheat to the Quebec and has partnered with McGill University to use the latest genomic techniques to ensure that this process is as efficient as possible.

Optimization of Bioink Composition for Efficient Mesenchymal Stromal Cell Chondrogenic Differentiation in an Animal Component-Free Culture

Culture of cells in three-dimension (30) allows cells to interact with their surrounding and grow in all directions and behave in a manner that is more closely associated to how they would in vivo as long as their nutrient and environmental requirements are maintained. In this context, bioprinting offers an advantage over 20 cell cultures as it allows cells to be mixed with growth factors and biomaterials that can be printed into structures that mimics the natural tissue characteristics. Cartilage repair due to trauma or disease has been proven difficult in vivo by traditional methods.