Vitamin D compounds are being developed for the treatment of chronic kidney disease. The purpose of this proposal is to develop a cell-based screening platform that will allow the rapid assessment ofrelative efficacy of a library of compounds. The intern will use recombinant DNA methodology to generate a cell-based assay in which the green fluorescence protein will be inserted into a vitamin D responsive gene; thus, permitting the visualization of vitamin D signaling in real-time.
This project will produce material, in the form of lesson plans, instructional guides and practice sheets, appropriate for a college-level foundational mathematics course and will monitor its effectiveness during an implementation at on Ontario college in the fall semester, 2009. Once completed, the material will become part of JUMP's growing body of course materials. It is hoped that the material will prove effective in addressing the mathematics requirement of college students and will be adopted at more institutions, fulfilling JUMP's goal of "[promoting] a numerate society".
This project is in partnership with AUTO21. Van Rob is an automotive parts manufacturer of metal stampings with plants in the Toronto area. The objective of this internship is to evaluate the performance of a machine vision inspection system in an industrial environment. The evaluation of the intelligent neuro-fuzzy inspection algorithm used by the machine vision system known as QVision is the subject of the intern’s Master’s thesis. The original QVision was developed by a previous Master’s student. QVision has been installed on one of Van Rob’s Manufacturing cells.
Police commonly create composite pictures of criminals in order to aid their search for suspects. Traditionally, composites have been created from large sets of pictures or line drawings of features, (e.g. eyes, mouths, noses, hair). Such systems produce poor likenesses. 3D Sherlock Software is a computer-based program for developing facial composites that relies on three dimensional facial images. The program works iteratively based on images selected by users to move towards a better and better likeness of the target individual.
This project is in partnership with ISIS Canada. Bombardier’s Advanced Rapid Transit (ART) solution is a medium capacity transit system, filling the gap between street‐running trams (low capacity) and heavy rail metros (high capacity). This internship aims to understand the design decisions and how new approaches and technology can reduce the costs of civil infrastructure for ART systems. The prime focus of this study is on the guideway (beams, columns, footings) and its cost.
Solar photovoltaic cells convert sunlight directly into electricity. As the technology has evolved it has become increasingly attractive to companies to invest in large solar farms. Solar energy is an inherently intermittent resource. For companies to invest millions (each 10MW solar PV farm represents an investment somewhere between $40 ‐ $45 million) in developing solar farms they must possess extremely reliable predictions of the energy output of the system.
Litens Automotive currently uses an axially mounted non-contact magnet based rotational position sensor in several applications to accurately and precisely measure shaft rotational position. This type of sensor has no moving parts, which allows it to be extremely durable with respect to useful life. With this robustness, coupled with low per unit cost, it has great potential to be used in mass produced items.
The advent of new weapon-mounted technologies poses new challenges for assault rifle design. Changes in rifle weight and center of mass (COM) can have significant impacts on soldiers’ rifle handling and ability to engage a target. Defense Research and Development Canada (DRDC), as part of a larger NATO Task Group, have hired Human Systems Inc., to investigate integration issues associated with new weapon systems. Testing will be conducted on a highly secured live-fire range using experienced Canadian soldiers as subjects. Human Systems Inc.
Haptics is a growing area of robotics in which users physically interact with dynamic real/virtual environments via active robotic hand-controllers, known as “haptic devices”. Recent emerging applications of haptic technology such as rehabilitation or surgical training simulators require stable high-performance human-to-human interaction in real/virtual environments. Such haptic interaction requires powerful high-performance haptic devices that can produce large force/torque levels suitable for human-level interactions over sustained periods of time.
The desire to offer on-demand 24/7 services means there is pressure to quickly identify and resolve problems in a database management system (DBMS). Problem determination tools rely on the existence of sufficient monitoring data to support analysis but monitoring introduces overhead and so causes decreased application performance. The proposed research seeks to provide effective light-weight tools for monitoring and analysis to support problem determination in DBMSs.