Obesity has become an important public health problem worldwide. Weight loss strategies based on meal replacements and a higher protein intake have been growing in popularity. The synergistic effects of a combined high-protein meal replacement (HP-MR) on metabolism have only been recently explored by our research group during my doctoral studies. This was done using Almased (Almased USA, Inc., Wellington, FL, USA), a commercially available HP-MR. As an expansion of my previous work, this proposal is part of the Premium Study.