The goal of this Mitacs research proposal study is to develop and apply experimental methodology for transdermal delivery of bone-targeting peptide hormone drugs. We aim to deliver these compounds using an appropriate hydrophilic-hydrophobic Diffusimax liposomal drug delivery cream base to anatomically superficial bone, at the sites of stress fractures (also known as “shin-splints”) in order to trigger bone repair, reduce pain burden, and to minimize possible side effects if those drugs were used systemically.

Egg yolk contains IgY antibodies that target various infectious disease and food allergens. IGY Inc is a company focused on utilizing chicken immune system for antibody production. IgY antibody contains 0.64% of total wet egg yolk, after cracking each egg IGY Inc generates 60-70g of liquid egg white which has a low commercial value. Egg white is a rich source of dietary protein and also known for its biological activities. Therefore the primary objective of this study is to develop a pragmatic technique to hydrolyze egg white to produce peptides with biological activity.

Improving feed efficiency (FE) and meat quality (MQ) are Canadian swine industry priorities that will increase sustainability and competitiveness. It is difficult to improve these traits simultaneously by traditional breeding methods due to limited knowledge of genetic interactions, limitations on animals that can be measured and the high cost of measurement. High throughput genomic technology has the potential to positively impact these issues. Our overall purpose is to develop a genomic assisted breeding program to simultaneously improve FE and MQ.

Biosolids, the materials produced during treatment of sewage sludge, are produced in extremely large amounts each day in every town and city across the globe. This material contains significant amounts of bacteria, viruses, and parasites that can be detrimental to human heath and must be carefully disposed. Added to this, there are currently few uses for biosolids even after sterilization. Municipalities around the world, including our partners with The City of Edmonton, are eagerly looking for novel and innovative technologies that will consume biosolids.

Pipeline operators are required to make decisions for various complex pipeline integrity situations on a daily basis. These integrity situations often comprise a complex interaction between integrity threats such as corrosion, cracking, third party damage, dents, buckles, and wrinkles. A pipeline operator usually develops their own processes towards dealing with each specific integrity threat. In general, the processes are developed based on the stipulations by the Canadian Oil and Pipeline Systems Standard, the in-house experience, and the current up-to date integrity specific research.

Myasthenia gravis (MG) is caused by an immune attack on the nerve and muscles junctions and manifests as severe and sometimes life threatening muscle weakness. A number of effective immune modifying medications are available for MG. Intravenous immunoglobulin (IVIG) – a fraction of blood harvested from thousands of donors and containing high concentration of immunoglobulins, is a highly efficacious therapy for MG. Unlike some other therapies, response to IVIG is quick and therefore commonly used in MG patients in whom rapid response is needed.

In order for Canadian industry to continue to meet the high demand for energy they must adhere to the social and environmental pressures to reclaim and restore the extraction sites to fully functioning ecosystems, and to offset environmental destruction when appropriate. Recent changes to Canada’s Fisheries Act in 2012, have enshrined offsetting strategies as a legislative means of compensating for the loss of commercial, recreational or Aboriginal (CRA) fisheries. In Alberta’s Oil Sands Region, the creation of new lakes (i.e.

In addition to food uses, vegetable oils are increasingly a source for renewable biomaterials and biofuels. Recent progress in the development of a biobased economy is focused on introduction and improvement of novel crop plants for non-food applications. The proposed project is part of an international collaborative effort to develop camelina as a new industrial oil platform.

The objectives of this study are: • To assess the feasibility of using satellite remote sensing technology to measure trace gases and aerosols over northern Alberta. • To study the transport of biomass burning emissions and its impact on air quality over northern Alberta. Methodology: Data from several satellite sensors will be used in this study coupled with AErosol RObotic NETwork (AERONET) ground measurement data, In-service Aircraft for a Global Observing System data (IAGOS), meteorological data and Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) Model.

The current approach for testing compounds of interest in blood such as drugs or nutrients involves drawing blood samples into vials that then require refrigeration prior to testing. Since transportation to remote laboratories is challenging, people need to go into medical labs to have their blood tested. This research will develop improved techniques that enable blood samples to be collected from a finger prick onto a specially designed card that eliminates biohazards and makes the sample stable at room temperature so that it could be mailed or sent by courier to a lab.