Closed-loop flow control for microfluidic 3D bioprinting

Aspect Biosystems is developing a novel microfluidic 3D bioprinting technology that has the potential to fundamentally change the way many diseases are treated through the creation of functional human tissue. The technology manages highly complex fluid handling operations and requires sophisticated control systems to deliver reliable and repeatable results. This project is focused on developing such a control system specifically for fluid flow control through the microfluidic printhead.

Investigating the efficacy of GelDerm* in detection of wound infection in a rat model

Burn injuries and wounds caused by burns are big health problems and in Canada alone cost nearly $290 million. Additionally, these wounds usually persist and become infected and subsequently drastically compromise patients’ health, result in significantly longer hospitalization, delayed wound healing, higher costs and higher risk of death. Therefore, prevention and management of wound infections have priority in treatment of burn patients. In order to early diagnose microbial infections in wounds and accelerate wound healing to such injuries, 4M Biotech under leadership of Dr.

Data-driven modeling and uncertainty quantification in infrastructure science and engineering

Few centuries ago, building palaces and castles were based on past experiences and observations, hence, resulted in very inefficient designs with wall sometimes as thick as 1~2m. Today, computer modeling provides a low-cost way of predicating what may happen when engineering structures are subjected to different loads and conditions. We know that some loads are such as weight of the structure, however, others like wind can have a probabilistic nature.

Masters Athlete Screening Study (MASS) - Part 2 (5-year evaluation)

Masters athletes (>35 years) are a rapidly growing population that participate in a variety of sports. While exercise has tremendous health benefits, there is a small absolute risk of a heart attack and sudden death during exercise. Prevention strategies, such as heart screening aim to identify heart disease that may serve as a trigger for fatal adverse events. This will be the first prospective longitudinal study in Canada examining the effectiveness of heart screening in Masters athletes.

Automated Multi-Factor Medium Optimization of Human Hematopoietic Stem Cell Expansion Using Design of Experiments

This project aims to support ExCellThera's current clinical trial (ECT-001) to improve blood stem cell transplantation outcomes for patients suffering from a host of blood malignancies. A critical aspect of developing clinical therapies using stem cells involves accurate and robust control of stem cell behavior in controlled laboratory conditions. Cell growth conditions (media) should mimic the native environment of the cell of interest.

Evaluation of Cultural Change Interventions in the Workplace

Habanero Consulting group is partnering with Postdoctoral Researcher Ryan Taylor and Professor Bryan Gick from the University of British Columbia, and Fernando Nieto Morales from the Colegio de Mexico. They will apply the most current research from the social sciences to strengthen Habanero?s cultural transformation techniques and create a tool to more quickly and accurately diagnose impediments to organizational improvement.

UPnGO with ParticipACTION: Evaluating the evolution of a national workplace physical activity initiative – Part 2

In order to improve the health and work productivity of Canadians, ParticipACTION developed a rewards-based, PA tracking intervention called UPnGO with ParticipACTION. The UPnGO program aims to increase the amount of PA and decrease the amount of sedentary activities throughout the workday. This program was released to the public in Fall of 2017, however, program participation hasn’t been as successful as we would like, and participants are not getting the PA benefits the program is designed to achieve. We are working to redesign the program to address these issues.

Water-based binders for the 3D printing and sintering of metals

Rapidia has developed a water-based approach to metal 3D printing that is faster, simpler, and more cost effective than the current systems on the market. This novel approach enables printed parts to be sintered directly, eliminating the time- and chemically- intensive intermediate de-binding step required for other processes. In order to implement this technique, the formulation of the initial paste used for printing is an essential component to optimize.

The impact of residential displacement on health among people who use drugs living with HIV in Vancouver, Canada

Residential displacement is common among people who use drugs (PWUD). However, we know little about the impact residential displacement has on their social and health outcomes. PWUD living with HIV may experience particularly detrimental consequences due to their structural vulnerability and complex realities of their everyday lives. Focusing on PWUD living with HIV, this study will explore the health consequences of displacement from housing in the West End and Downtown Eastside neighborhoods of Vancouver, British Columbia.

Development of a UV-LED disinfection system for ice-machines.

Contamination by microorganisms is a well-known problem for commercial ice machines. Frequent applications of sterilizing chemicals are necessary to keep the ice machines sanitary, a costly and time-consuming process. The sources of this contamination are microorganisms associated with the water used as the source for ice production, the incoming air to the ice machine, and the interior surfaces of the ice machine. Disinfection of contamination sources using ultraviolet (UV) radiation inactivates microbes prior to their establishment inside the ice machine.