Effective knowledge translation of evidence-based best practice for healthy lifestyle behaviours - Year two

The research supports the effective knowledge translation of evidence-based best practice information related to healthy lifestyle behaviours. Over a two-year period, the post-doctoral fellow will create a series of knowledge translation tools that can be used in the effective primary and secondary prevention of chronic disease through lifestyle behaviour modification. Our proposed initiative will capitalize on the best of the existing models of health promotion.

A Novel Combination Therapy to Target Primitive Acute Myeloid Leukemia Cells - Year two

Modern molecular targeted therapies have shown promise in treating some blood cancers, but a cure remains elusive for most acute leukemia patients. This is largely due to the survival of some leukemic cells that possess unique properties and can cause treatment failure or relapse, warranting identification of new, distinct targets for improved therapies. In collaboration with Signalchem Lifescience Corporation (SLC), we aim to develop and test a new drug combination strategy to target acute myeloid leukemia (AML) patient cells that are resistant to current therapies.

Baseline parameters for application of human 3-D organoids as an in vitro model for studying neurotropic viral infection

Viruses that infect the brain, such as Zika virus, are a significant threat to public health in Canada since many are poorly understood, and no vaccines or antivirals exist to combat them. We are investigating the use of “mini-brain” organoids derived from human stem cells as a model to study Zika virus infection that mimics the physiology of the human brain. Here, we seek to optimize our methodology for infecting brain organoids with Zika virus.

Data-Driven Intelligent Agents for Personalized Training on Design & Computational Thinking Skills

Computational thinking, i.e., the ability to formalize and solve problems with the assistance of computers, has become crucial in a growing range of jobs. Recent research in education has provided encouraging evidence that the development of computational thinking is the most effective when it is taught in the early childhood, and that game-based learning (GBL) technologies are extremely valuable in this context. However, children often need help when learning with GBL software.

Next-generation antibody drug for immuno-oncology treatment: anti-TIM3 antibody development

Unprecedented advances have been made in the treatment of cancer through the use of antibody against immune checkpoints, priming immune system instead of targeting cancer, with approval of several antibodies for multiple cancer types. However, so far we are merely seeing the tip of the iceberg because responses to this form of therapy are not universal. Next-generation antibody drug is needed. TIM-3 negatively regulates immune system and is one of the next generation targets. We have generated 13 clones of TIM-3 antibodies, potentially can be anti-tumor drug.

Braiding new possibilities for co-existence: holding spaces for difficult conversations

This project uses social cartography as its main methodological and collaborative tool to map practices that enable or hinder successful collaborations in spaces of socially engaged art between members of various communities in historic dissonance. These include artists from Indigenous and other racialized communities. More specifically, this project explores the potentials of post-representational uses of social cartography, as forms of “cognitive art” that are socially engaged in ways that challenge dominant forms of representation and agenda setting.

A humane pigeon management plan for TransLink: the case of Ovocontrol P

Pigeons can act as pests for the ability to spread disease as well as ruin infrastructure with their excrement. At Skytrain stations, they cause delays by triggering intrusion alarms as well as erode infrastructure. By attempting to reduce population numbers using a type of avian reproductive control that does not effect the environment or other species called Ovocontrol P, we can attempt to reduce population numbers in a humane way that does not involve culling the pigeons.

Pilot-scale preparation of phospholipid-free small unilamellar vesicle formulations with potential in treatment of hepatic diseases

Lipid-based nanoparticular drug formulations are a successful technique to enable targeted treatment. The Canadian company Precision Nanosystems Inc. (PNI) develops the innovative instrument family NanoAssemlr for lipid nanoparticle preparation based on microfluidics. These instruments are fast, easy-to-use and provide a high batch-to-batch reproducibility and quality. Recently, we developed a novel lipid nanoparticle formulation with the unique feature of selective liver targeting, which could only be prepared with NanoAssemlr Benchtop at relatively small scale.

Enhanced Model Suitability Analysis in Catastrophe Modelling through an Improved Understanding of the Seismic Hazard in Western Canada

One of the most destructive natural disasters that Canada could experience is a major earthquake affecting a highly-populated area. A 2013 study commissioned by the Insurance Bureau of Canada estimated that a magnitude 9.0 earthquake in British Columbia, and a magnitude 7.1 earthquake in the Quebec City-Montreal-Ottawa corridor would result in financial losses of almost $75 billion and $61 billion, respectively.

Investigating the microscale structures and rheological properties of oil water-gellant complexes for the development of gelators in remediating surface-water oil spills

Oil spills pose both acute and chronic hazards to ecosystems and require effective and timely treatment. As large quantities of crude oils are transported across and in the proximity of oceans. rivers. and other waletways, it is especially important to be prepared for spills into water. The dynamic and variable character of aquatic environments especially highlights the need for rapid, dexterous responses.

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