This research aims at life cycle thinking-based comparison of popular wall material (i.e., wood, concrete, masonry, etc.) for institutional, commercial, and industrial (ICI) building construction in Canada. Empirical studies will be used to observe the deterioration of interior and exterior masonry wall systems in various climatic regions. Life cycle sustainability assessment would be used to evaluate social, environmental, and economic impacts. Alternative wall construction methods will be compared using a methodological framework that integrates TBL, resiliency, and occupant health.