Radiochemistry for the Pharmacokinetic Evaluation of Novel Bone-Targeting Peptide Hormone Derivatives Year Two

This proposed research project is about development of new bone-targeting drug called PTHPEG- BP, this new compound will overcome shortages of current clinical peptide hormone PTH, and show better treatment efficacy and lower price then the latter; several new technologies will be used on research of this PTH, such as micro Positron Emission Tomography (PET/CT), and several of its characteristics will be identified such as structure, bioactivity, and metabolism inside body.

Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme Year Two

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals without the need to genetically modify the cells.

Development of Radio-Imaging Agents Targeting Necroptosis Year Two

The joint-effort project by Nordion Inc and the University of Ottawa Heart Institute aims to develop a series of radiolabeled necrostatin derivatives, which act as imaging agents based on necroptosis (programmed necrosis - a type of cell death) inhibitors to help diagnose disease (such as cardiovascular, neurological diseases and cancer) and monitor their treatment effects. The roles of the fellow are to design, synthesize and characterize these agents and to assist in testing their biological properties through further in vitro and in vivo evaluation.

Development of Fast Longitudinal Cortical surface extraction, deformation, and Normalization (FALCON) for the measurement of cortical thickness over time from brain magnetic resonance images Year Two

The project involves development, validation, and application of new medical image analysis algorithm where cortical thickness is measured from serial brain magnetic resonance imaging (MRI) with improved efficiency and greater sensitivity. Cortical thickness is a relatively new metric that correlates with clinical and cognitive worsening in a variety of neurologic disorders such as multiple sclerosis and Alzheimer's disease.

Postnatal development in mice and rabbits: an histomorphological study

his study focuses on the postnatal histomorphology of developing organs in mice and rabbits and compares the key events between human and experimental species (mice and rabbits). It will provide an essential resource for nonclinical safety evaluations of pediatric drugs and will be helpful in preparing appropriate study designs and testing strategies. Neonatal and juvenile organs greatly differ morphologically and functionnally from adult animals.

The evaluation of pain management strategies for either caustic paste or cautery disbudding in dairy calves Year Two

Destruction of the horn bud in 4-6 wk old calves using either hot-iron or chemical disbudding is a common practice in the dairy industry. There is a limited body of research on the effects of chemical disbudding and the pain it causes to the animal as well as research on appropriate methods to mitigate the pain following this procedure, and research to identify appropriate pain managements is needed.

Detection and prevention of preeclampsia using metabolomics and Vaccinium leaf extract for human trophoblast survival

Blueberry leaves are gynaecological aids and inhibitors of advanced glycation endproducts (AGEs). AGEs cause atherosclerosis, kidney, vascular, and neurological diseases through an oxidative process and correlate with preeclampsia. Preeclampsia affects 2-7% of women and is a leading cause of maternal/perinatal mortality. A woman dies of preeclampsia every eight minutes worldwide. Unfortunately, randomized trials evaluating dietary, vitamin, mineral treatments showed minimal benefit in reducing preeclampsia. AGEs are associated with preeclampsia.

Evaluating New Methods for Monitoring Cognitive Health Year Two

Copeman Healthcare Centre is engaged in a multi-year research and development program in the area of cognitive health. Cognitive health is a surrogate marker for brain health. All other technologies, such as biomarkers, electrophysiology, structural brain imaging, and functional brain imaging attempt to measure damage to the brain. Moreover, these technologies do not measure or quantify the healthy brain or its functioning; they are used to detect what appears to be wrong based on anatomical or physiological indicators.

Evaluating New Methods for Monitoring Cognitive Health

Copeman Healthcare Centre is engaged in a multi-year research and development program in the area of cognitive health. Cognitive health is a surrogate marker for brain health. All other technologies, such as biomarkers, electrophysiology, structural brain imaging, and functional brain imaging attempt to measure damage to the brain. Moreover, these technologies do not measure or quantify the healthy brain or its functioning; they are used to detect what appears to be wrong based on anatomical or physiological indicators.

Guided Catheter System Based on Smart Polymeric Brush Coating for Vascular Surgery Year Two

Ventures (IV)~ Canada supports the development of novel application for guided catheters and serving the CVD market, it will directly benefit from this research. We anticipate generating new intellectual properties based on the work described. N previously licensed a technology from the research performed in Kizhakkedathu and Phani's laboratories on catheters and the current project will expand that technology further.

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