ENGAGE: The Role of Academic Research and Technology Innovation for Improving Parkinson’s Disease Outcome and Life-style modifications Year Two

Phase I: Development of Intellectual Property to Facilitate Partnership Agreements with Business and Non-profit Organization. Before partnership agreements with the business sector (companies) and not-for-profit organizations can be undertaken, intellectual property rights need to be established.

IMPACT (IMproved Pulmonary repair with Advanced Cell Therapy) for Acute Respiratory Distress Syndrome

When people become critically ill, such as during severe infection, their lungs often fail – this is termed "Acute Respiratory Distress Syndrome" (ARDS). ARDS is common, and often fatal. There is no drug therapy for ARDS and new therapies are urgently required. Mesenchymal Stem Cells (MSCs) from bone marrow offer significant hope for ARDS, and early research findings are promising.

DLVR Drug Delivery Characterization

Highly targeted therapies can be devised to treat a variety of cancers, specifically acting on the mutated genes causing tumor growth. One challenge with such techniques is delivering the therapy to the interior of the cancer cell, when enzymes in the blood can actively break down the therapeutic molecules or when delivery to healthy cells can cause toxicity. Nanoparticle carrier molecules can solve this problem by containing the payload and delivering it directly to the cancer cell.

Investigation of a novel Spatially-Sensitive Transmission Detector for real-time verification of radiation beams during Radiation Therapy

Unprecedented advances have been made in Radiation Therapy during the past two decades. High precision treatment plan is generated using sophisticated optimization methods, and treatment is delivered with complex intensity modulation techniques. Due to the complexity, the burden of Quality Assurance (QA) for modern radiotherapy has also increased dramatically.

Dissecting the role of PCSK9 in sepsis

Severe sepsis strikes young and old alike with an increasing incidence of >75,000 per year in Canada at a cost of $40,000 per patient. In 40% sepsis is complicated by low blood pressure and organ failure with a mortality rate of 30-60%. The number of deaths due to severe sepsis and septic shock is greater than the number of deaths due to acute myocardial infarction. The process that links infection to organ failure and death is triggered by bacterial toxins, including lipopolysaccharide, lipoteichoic acid, and phospholipomannan. Pathogen toxins are cleared from the blood by the liver.

Pediatric Cancer Drivers: From Target Discovery to Clinical Translation

This research cluster, a joint initiative between the Sorensen Lab at UBC and the Morin Lab at SFU with a number of key partners, involves a multidisciplinary approach to better understand the role of genetic changes in individual types of pediatric cancer, and how we might use this information to design better treatments for these diseases.

Design and Synthesis of Specific Inhibitors of CYP26 for Blocking Retinoic Acid Metabolism: A Safer Approach to Retinoid Therapy for Skin Disease Year Two

Acne is a common human skin disease which is highly prevalent during adolescence, and often continues into adulthood. Retinoids, such as isotretinoin (Accutane/Roaccutane), have been particularly effective systemically in the treatment of acne. Although, millions of patients have been treated with Accutane/Roaccutane which for many years generated more than $1B U.S. in annual sales, the side effects, such as birth defects and inflammatory bowel disease, can sometime be severe. The market opportunity of an effective treatment with a better safety profile than isotretinoin is significant.

Development of an Actigraph System for Sleep-Wake Identification

The main objective of this project is to design a proper algoritlun for analyzing COPD patient's sleep data as an important feature in patients treatment procedure. The data would be gathered by a novel wrist wearable actigraph with high accuracy technology. The wearable wristactigraph will allow more reliable data collection because the subjects can use it in their own home environment and there is no limitation for the length of data collection period. The intern will receive the proper raw data gathered by the actigraph, and focus on the analysis part of the project.

Application of neuroimaging to optimize observational learning from a mobile application: influences of age and brain function

One side effect of stroke is damage to the left parietal lobe, important in motor control of the right hand. Many stroke patients experience loss of motor skills and have difficulty relearning how to perform daily tasks. Recent reports from stroke rehabilitation centres have shown increased improvements in relearning basic motor skills upon incorporation of observational learning techniques into their therapies.

Biomechanical Comparison of Underwater Treadmill Running and Land Treadmill Running

The proposed research project aims to understand and quantify the biomechanical factors of running on an underwater treadmill, as compared to running on a land treadmill. By understanding the vertical ground reactive forces and order of muscle recruitment at various speeds, resistance and levels of buoyancy, practitioners in the field of sports medicine can effectively use the technology to enhance the management of athletic injuries. Fortius Institute, Inc.

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