Nowadays, the balance of omega-3 and omega-6 fatty acids (FAs) has shifted in favour of the latter and fiber consumption has decreased, both of which are associated with poor cardiometabolic health. Omega 3 FAs and fiber may impart their health benefits by modulating the endocannabinoid system (ECS) and the gut microbiome, both of which are key regulators of cardiometabolic health and obesity. Whole hemp seeds possess excellent nutritional value; rich in omega-3 FAs, fibers, proteins and vitamins and minerals.