Investigating the role of probiotics in cell death and intestinalbarrier integrity

Our gastro-intestinal tract is colonized by billions of microorganisms that constitute the intestinal flora or microbiota. These microorganisms, primarily bacteria, are required for our development and physiology; however, changes in the "normal" composition of the microbiota, referred to as dysbiosis, have been linked to chronic inflammatory diseases in humans. Currently, a major research effort is to understand what these commensal bacteria are, how they maintain health, and how their dysregulation causes disease.

Quantitative Digital Pathology Algorithm for an Automated Cancer Slide Imaging System

Digital Pathology provides a great reliable source for cancer diagnosis; however, this relatively new technique lacks an appropriate method of regulation and standardization. As a result the information obtained from cancer imaging system might suffer from inconsistency of the results (repeatability and reproducibility issues). Working with the BC Cancer Research Center, Logipath Medical Inc. has developed a number of quantitative pathology systems some of which have been spun off to commercial entities.

Identification of non-coding RNA involved in castrate-resistant prostate cancer

Prostate cancer (PCa) is the most common cancer affecting Western men. Unfortunately, treatment for advanced prostate cancer is strictly palliative and lethal treatment-resistant disease eventually arises (castrate-resistant prostate cancer (CRPC)). Interrogating the genome of pre and post CRPC allows for the identification genetic differences that drive progression and resistance, representing candidate therapeutic targets and molecular biomarkers.

Development and validation of an algorithm forsegmentation of the cochlea from medical images

A cochlear implant (CI) is a complex electronic device designed to provide the sensation of sound to profoundly deaf or severely hard-of-hearing individuals. Imaging of the implanted CI electrode would assist manufacturers in verifying the efficacy of their designs and would also provide important information to clinics for programming CIs post-surgery. However, the size and position of the cochlea in the body make it difficult to image using clinical imaging scanners.

DEVELOPMENT OF ROTATIONAL THROMBOELASTOMETRY (TEM) BASED TRANSFUSION GUIDELINES FOR THE OPTIMAL MANAGEMENT OF EARLY RESUSCITATION OF BLEEDING TRAUMA PATIENTS

Bleeding following traumatic injury is the leading cause of early cause of death. Currently these patients are treated based on the results of time consuming laboratory tests resulting in inappropriate usage of blood products and poor survival rates. Rapid recognition of defects in clotting mechanism is necessary to stop bleeding in trauma patients.

Analyse de la cinématique 3D de la marche chez des patients souffrant de douleur post-prothèse totale du genou

Les études démontrent que 15-20 % des patients sont insatisfaits en post prothèse totale du genou. Plusieurs de ces patients présentent de la douleur antérieure. Dans le cas du syndrome fémoro-patellaire, différents déficits biomécaniques pouvant expliquer ces symptômes ont été identifiés. Cependant, aucune étude ne s’est intéressée à la biomécanique du genou chez une population souffrant de douleur post prothèse.

Developmental potential of oocytes after cryopreservation Year Two

Oocyte cryopreservation is imperative for assisted reproductive technologies (ART). It offers cancer patients to preserve their oocytes for future fertilization, flexibility in the timing of infertility treatment, and the potential for establishing oocyte banking. However, the currently available protocol is limited because the oocytes after cryopreservation have lower ability to develop into viable embryos (developmental competence) compared to unfrozen oocytes.

Assessment and selection of competent oocytes for embryo development Year Two

The incidence of female infertility is on the rise in Canada, afflicting up to 17% of woman between the ages of 18 to 34 and with a considerably higher rate of occurrence in woman over 34. Many infertile women are now turning to assisted reproductive technologies (ART) to facilitate conception and child bearing. Female oocyte/egg competence is an important requirement for successful ART outcomes. A competent oocyte is characterized by its ability to mature, become fertilized, and develop into a viable embryo.

A PROPOSAL FOR CONTINUATION OF A RESEARCH PROGRAM TO INVESTIGATE THE ROLE OF CATHEPSIN K IN OSTEOARTHRITIS (OA) AND CREATE NEW DIAGNOSTIC ASSAYS FOR THE EARLY DETECTION OF OSTEOARTHRITIS

Osteoarthritis is a chronic painful disease of joints that involves the progressive destruction of the articular cartilage and bone and leads to pain. It affects both humans and animals. Animals can serve as models for the human disease and in this case we will study equine OA. There is currently no effective medication that can effectively reverse the cartilage destruction in OA. This is mediated by enzymes. It was believed to be due to MMP enzymes alone until recently we showed that Cathepsin K is also involved.

Cross modality image processing in cardiac and spinal images

With the advances of medical imaging, accurate diagnosis has been significantly enhanced, especially when utilizing cross-modality imaging for complicated diagnoses such as the spine and cardiovascular system. However, cross modality image processing poses a challenge due to large amount of data generated. Computer Tomography (CT) and Magnetic Resonance Imaging (MRI) images, for example, have great capacity for screening, diagnosis, treatment and prevention of cardiac and spinal diseases.

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