Regulation of N-type calcium channel activity by Opioid receptor-like receptor - a novel mechanism to eliminate morphine tolerance

Prolonged morphine treatment is known to cause an up-regulation of ORL1 receptors in the spinal cord (12, 13), which in turn is believed to contribute to the development of morphine tolerance by altering ?-opioid receptor mediate modulation of N-type calcium channels. Indeed, ORL1 antagonists can reverse the development of tolerance, and ORL1 knockout can mediate resistance to tolerance with no changes on the acute analgesic effects of morphine (14, 15). Our lab has shown that ORL1 receptors and Cav2.2 channels form a physical signaling complex that results in tonic G??

Predictive microsimulation model for knee-OA progression and cost-effectiveness of earlynon-pharmacological therapies to improve long term patient outcomes

The proposed study has three objectives:

Objective 1. Develop KOA microsimulation model: To develop and validate a Knee-OA population-based microsimulation model (POHEM-KOA) using the previously developed POHEM-OA model.

Objective 2. Perform cost-effectiveness analysis of non-pharmacological therapies for KOA: To use POHEM-KOA in conducting a cost-effectiveness analysis of treatment strategies, including exercise therapy and weight reduction, targeted at obese and overweight early OA patients in Canada over the next 20 years [2013, 2033].

Biomechanical Factors as a Diagnostic Aid for Aortic Pathologies

We have developed a software tool that could be used as stand-alone software, or could be implemented in a vascular diagnostic suite (for example within the post-processing software that accompanies most CT and MR scanners). The tool would allow surgeons and radiologists to better evaluate the current state of the aorta under examination and the likelihood of rapid enlargement, rupture or dissection. This added tool would be used together with the existing vascular diagnostic tools, such as diameter and rate of growth providing an improved and more effective diagnosis.

ENGAGE: The Role of Academic Research and Technology Innovation for Improving Parkinson’s Disease Outcome and Life-style modifications

Phase I: Development of Intellectual Property to Facilitate Partnership Agreements with Business and Non-profit


Smarter Collaborative Software to Support Energy Operations Centers

For so many years, industries that are heavily reliant on geospatial data have been working with paper maps unfolded on tables. Some of these companies are still using paper maps to analyze huge amounts of data despite the current availability of geographic information system (GSI) for storing and managing geospatial data. Data management tasks using these traditional methods are asynchronous and very tedious. Delays in updating these maps can pose a safety risk for field workers who may be guided based on outdated information.

Joining lifestyle and cognitive assessment with Fit Brains Trainer data: Can Fit Brains brain fitness apps tell us what a “smarter” lifestyle look like?

Rosetta Stone Canada collects user demographic and performance data from Fit Brains Trainer (brain fitness training games), Cognitive Assessment, and Lifestyle Assessment mobile apps. Data from the three apps can be linked and analyzed to answer research questions such as how lifestyle factors can influence brain training habits and outcome. This internship will: 1. Statistically explore raw data in Cognitive and Lifestyle Assessment databases 2. Statistically normalize data in Cognitive and Lifestyle Assessment databases 3.

How Teachers Understand Self-Regulation: Connecting the Canadian Self-Regulation Initiative with Pearson Canada Inc

The notion of ‘self-regulation’ in the development of children and young people and the health of adults has taken on considerable importance, especially in education, as the science investigating this feature has made significant advances over the last decade. One nationwide initiative, the Canadian Self-Regulation Initiative (CSRI), has been working since 2012 to support educators’ understanding about self-regulation and their ability to integrate these ideas into their practice.

Projet supervisé – Élaboration d’un référentiel de compétences pour les activités clés de démarrage d’une entreprise technologique

Les entreprises en démarrage au Centech sont formées d’équipes multidisciplinaires dont les membres fondateurs possèdent des formations de premier et second cycle en ingénierie et en administration. Ces individus qui passent du statut d’étudiant à celui d’entrepreneur ont besoin d’acquérir rapidement des connaissances et une expertise solide, afin de faire croître rapidement leur entreprise à travers les trois phases du cycle d’incubation : l’émergence, le prototypage et la commercialisation.

Development and Piloting of Nationally Leading Curricula for Job Coach Training in Autism Spectrum Disorder

This project will develop, pilot and evaluate a training program for job coaches and other related support providers to person with Autism Spectrum Disorder, using several sequential steps, as follows. (1) We will conduct an environmental scan of existing job coach training curriculum. (2) We will present this information in focus groups across Alberta that include adults with autism, family members, job coahces, employes, and other key stakeholders that support the autism community and understand the role of, and potential issues for, job coaches in autism.

Résister à l’intimidation

Ce projet est en collaboration avec PREVNet. Des recherches ont prouvé que l’intervention des témoins d’une scène d’intimidation entre enfants met fin à l’altercation dans la majorité des cas. On a récemment conceptualisé quelques corrélations et prédicteurs d’intervention – ou de non-intervention – de la part des témoins, mais ces concepts n’ont pas été étudiés dans le groupe d’âge des 10‐12 ans, ni étudiés ensemble dans une même étude portant sur la contribution relative de chaque concept (et leurs effets cumulatifs potentiels) sur le comportement des témoins.