Water-Safe UV Curable Antimicrobials Nanoscale coatings for Plastics

The treatment of Hospital acquired infections from pathogenic bacteria continues to be a serious and significant burden on health care resources both nationally and globally. Currently, about 1 in 10 persons will acquire an HAI as result of a medical procedure which can result in an additional hospital stay, treatment and in some severe cases, death. To counter HAI’s, we propose the use of a new UV-curable antimicrobial coatings which will protect common touch surfaces (hospital beds, plastic items) from pathogenic bacteria.

Bacterial cellulose production using a novel microbe and its wound healing products

Bacterial cellulose (BC) is a natural polymer produced by certain bacteria in the form of nanofiber. Being a natural nanobiomaterial, it has been investigated for a broad range of applications ranging from headphone diaphragm to wound dressing and medical implant. The biochemical process for BC production using the well-established bacterium, Gluconacetobacter xylinus, is limited by the kinetics and oxygen availability resulting in a modest yield and long production time. In this project, we will investigate a recently discovered facultative bacterium for BC production.

Economic Assessment of a Predictive Technology for the Early Detection of Oral Cancer

Health economic evaluation provides information about the value for money of new healthcare technologies, and is increasingly used to guide the allocation of scarce resources based on maximizing health gain. The molecular diagnostics company, PDI, has developed a technology to improve the identification of patients at high risk for oral cancers for early intervention, and distinguish abnormal cell growth that will not become malignant, compared to the current gold standard alone.

DLVR Drug Delivery Characterization

Highly targeted therapies can be devised to treat a variety of cancers, specifically acting on the mutated genes causing tumor growth. One challenge with such techniques is delivering the therapy to the interior of the cancer cell, when enzymes in the blood can actively break down the therapeutic molecules or when delivery to healthy cells can cause toxicity. Nanoparticle carrier molecules can solve this problem by containing the payload and delivering it directly to the cancer cell.

Investigation of a novel Spatially-Sensitive Transmission Detector for real-time verification of radiation beams during Radiation Therapy

Unprecedented advances have been made in Radiation Therapy during the past two decades. High precision treatment plan is generated using sophisticated optimization methods, and treatment is delivered with complex intensity modulation techniques. Due to the complexity, the burden of Quality Assurance (QA) for modern radiotherapy has also increased dramatically.

A novel scaffold for tympanic membrane repair

The ability to hear, and the quality of our hearing, depends on the health of the eardrum. Eardrum perforations due to diseases and accidents can be treated using grafts, such as autologous grafts, allografts and xenografts. These replacements suffer from various limitations such as donor site morbidity, long operation time and healing time, and risk of infection transmission, and more importantly, none of these grafts are able to replicate the complex microanatomy for sound quality reproduced by the native eardrum.

Development of an Actigraph System for Sleep-Wake Identification

The main objective of this project is to design a proper algoritlun for analyzing COPD patient's sleep data as an important feature in patients treatment procedure. The data would be gathered by a novel wrist wearable actigraph with high accuracy technology. The wearable wristactigraph will allow more reliable data collection because the subjects can use it in their own home environment and there is no limitation for the length of data collection period. The intern will receive the proper raw data gathered by the actigraph, and focus on the analysis part of the project.

Raman Spectroscopy for in vivo Classification of Peripheral Lung Nodules

In Canada the five year survival rate for lung cancer is only at 15%. There is a great need to be able to detect the disease at an earlier stage which would lead to a better prognosis and outcome for the patient. Although many technologies and medical devices have been in use for standard procedure in the last decade, there are few which can detect lung lesions in the deeper portion, the periphery of the lung with reliability. The best option presently is called radial ultrasound, a device which focuses on tissue density but does not illuminate biochemical characteristics.

Optimization of a Dermoskeleton for Human Performance in Clinical and Occupational Applications

Physical disability in Canadian adults is largely due to painful mobility impairments, with the most common cause being diseases of, and injuries to, the musculoskeletal system and connective tissues (MSK disorders). MSK disorders are generally associated with natural aging, but are also caused by occupational injuries as well as brain or spinal cord injury or disease. The cost of these conditions to the Canadian Health Care system is in the tens of billions per year.

Online seizure detection using EEG-based features of neural rhythms measured from a wireless headset

Avertus Epilepsy Technologies Inc. is building a wireless headset that records brain waves (EEG) without requiring extensive, time-consuming, and uncomfortable patient preparation. Avertus’ SMART (Seizure Monitoring at the Right Time) Headset is a patient focused, point-of-care monitoring and detection system. Worn during the day or just at night during sleep, the SMART Headset represents safety, response when needed, and peace-of-mind. For drug companies and treating physicians, the SMART Headset provides an objective measure of seizure occurrence to assess drug efficacy.

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