Regulation of N-type calcium channel activity by Opioid receptor-like receptor - a novel mechanism to eliminate morphine tolerance

Prolonged morphine treatment is known to cause an up-regulation of ORL1 receptors in the spinal cord (12, 13), which in turn is believed to contribute to the development of morphine tolerance by altering ?-opioid receptor mediate modulation of N-type calcium channels. Indeed, ORL1 antagonists can reverse the development of tolerance, and ORL1 knockout can mediate resistance to tolerance with no changes on the acute analgesic effects of morphine (14, 15). Our lab has shown that ORL1 receptors and Cav2.2 channels form a physical signaling complex that results in tonic G??

Predictive microsimulation model for knee-OA progression and cost-effectiveness of earlynon-pharmacological therapies to improve long term patient outcomes

The proposed study has three objectives:

Objective 1. Develop KOA microsimulation model: To develop and validate a Knee-OA population-based microsimulation model (POHEM-KOA) using the previously developed POHEM-OA model.

Objective 2. Perform cost-effectiveness analysis of non-pharmacological therapies for KOA: To use POHEM-KOA in conducting a cost-effectiveness analysis of treatment strategies, including exercise therapy and weight reduction, targeted at obese and overweight early OA patients in Canada over the next 20 years [2013, 2033].

Correlation of Coronary and Myocardial Strain Profiles for Cardiac Resynchronization Therapy

Cardia Resynchronization Therapy (CRT) is aq pacing therapy used to reduce symptoms and mortality in patients with heart failure. It delivers a specialized pacing lead to the left ventricle (LV) through the coronary veins to re-synchronize the contraction of the heart when it has become delayed or desynchronous. However its benefit has proved to be dependent on the placement of this lead to regions where mechanical delay is maximal and does not have underlying myocardial scar. Medtronic Inc.

An evaluation of geohazards arising from gas hydrate dissociation in Canadian continentalmargins

The long-term research goal of the research group is to contribute to the fundamental state-of-knowledge on gas hydrates by improving methodologies and techniques for characterization, assessment, and development of natural gas hydrate accumulations. The short-term goal and main objective of the present proposal is to characterize and assess submarine geohazards evolving from gas hydrate instability.

Biomechanical Factors as a Diagnostic Aid for Aortic Pathologies

We have developed a software tool that could be used as stand-alone software, or could be implemented in a vascular diagnostic suite (for example within the post-processing software that accompanies most CT and MR scanners). The tool would allow surgeons and radiologists to better evaluate the current state of the aorta under examination and the likelihood of rapid enlargement, rupture or dissection. This added tool would be used together with the existing vascular diagnostic tools, such as diameter and rate of growth providing an improved and more effective diagnosis.

Control of point source low volume methane emission using methanobiofilteration technology

The research project identified here falls under the category of “clean energy technology”. Methanobiofiltration (MBF) is a new technology for the treatment of waste methane gas using a biological process, thus contributing to the reduction of the environmental impacts of current energy technologies. The lack of a complete technology package needed for various industry sectors has hindered its large-scale application in Alberta.

ENGAGE: The Role of Academic Research and Technology Innovation for Improving Parkinson’s Disease Outcome and Life-style modifications

Phase I: Development of Intellectual Property to Facilitate Partnership Agreements with Business and Non-profit

Organization

Smarter Collaborative Software to Support Energy Operations Centers

For so many years, industries that are heavily reliant on geospatial data have been working with paper maps unfolded on tables. Some of these companies are still using paper maps to analyze huge amounts of data despite the current availability of geographic information system (GSI) for storing and managing geospatial data. Data management tasks using these traditional methods are asynchronous and very tedious. Delays in updating these maps can pose a safety risk for field workers who may be guided based on outdated information.

Poultry health surveillance in Alberta for prevention of emerging infectious disease.

The broad objectives of this project are:

 

I. To reduce the risk of emerging infectious diseases related to poultry; and

II. To improve Alberta poultry industry productivity and profitability

 

To reach these broad objectives we will address 3 specific objectives:

Determine what the knowledge needs of the poultry industry are and how knowledge is best disseminated to improve disease prevention in poultry flocks and preparedness and response to disease outbreaks. 

Catalyst Development for Clean Hydrogen Production

The proposed research project looks at the hydrogen economy, where hydrogen can be used in place of fossil fuels for the worlds’ energy needs. Although touted as a sustainable option for global energy demand, the vast majority of hydrogen continues to be produced by industrial, fossil fuel-based processes such as steam reforming of natural gas. Our research aims to lower costs of hydrogen production in hopes to adopt wide-spread use and eliminate the need to rely on fossil fuels. Our partner organization, FireWater Fuel Corp.

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