Développement d’une approche de conservation systématique pour les milieux humides nordiques intégrant les services écologiques

Avec l’accroissement de la population mondiale, les territoires nordiques constituent un potentiel croissant de développement pour l’accès aux ressources naturelles. L’augmentation imminente des perturbations dans ces territoires risque d’entrainer un déclin de la provision des services écologiques, soit les bénéfices que les êtres humains obtiennent des écosystèmes. L’objectif de cette recherche est de caractériser l’impact […]

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Urètre reconstruit par génie tissulaire

Le Laboratoire d’Organogénèse Expérimentale (LOEX) a développé une technique alternative unique et innovante appelée auto-assemblage. Sur la base de cette technique éprouvée, notre équipe a développé une gamme de tissus génito-urinaires (vessie, uretère et urètre et vagin) présentant une organisation histologique très similaire au tissu natif et une très bonne résistance mécanique. Des tissus urétraux […]

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Décoder la représentation de la température par les neurones de projection de la moelle épinière à l’aide de l’imagerie cellulaire fonctionnelle in vivo

La thermoception consiste à détecter les changements de température ambiante et provoque des réponses volontaires et involontaires adaptatives, cruciales pour notre survie et notre bien-être. Les neurones de la moelle épinière reçoivent l’entrée des afférences primaires thermosensibles, modulent et intègrent le signal avant de l’envoyer au cerveau pour qu’il y soit décodé pour générer une […]

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Evaluation of an Automated Tooth Segmentation Tool

In dentistry, communication between dentists to plan treatment is very important. Originally, treatment planning involved communicating information by speaking or writing, often resulting in communication errors and misaligned expectations. The partner organization is involved in the development and provision of solutions for treatment planning and the development of software that can be used in dental […]

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Proteomic Profile of Dental Pulp Cells in Contact with Chitosan-Calcium Scaffolds for Pulp-Dentin Regeneration

In cases of reversible inflammation due to dental caries, direct pulp-capping therapies are an attempt to keep the tooth vital. Cell-homing regenerative therapies have been investigated in order to develop new biomaterials for a more successful treatment. Our scaffolds based on chitosan and minerals shows good in vitro results in terms of regenerating mineralized tissues, […]

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Zn-doped Coating Impact on the Titanium Salivary Pellicle

Teeth loss significantly impacts the quality of life of over 700 million individuals and is commonly addressed with implant-supported prostheses. Dental implants face biological and microbiological challenges, leading to potential infectious diseases and implant loss. Proteins from blood and saliva adhere to implant surfaces, influencing subsequent biological interactions crucial for implant success. These proteins quality […]

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Generator-Enhanced Computational Chemistry and Optimization (GECCO)

This project aims to use generative AI models to improve challenging tasks in computational chemistry and optimization. More specifically, by combining quantum computing with machine learning, the research will focus on generative AI methods to design molecules for accelerating drug discovery pipelines. Novel quantum subroutines for hybrid quantum-classical models will be designed, developed, implemented and […]

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Optimizing cell therapy manufacturing utilizing small molecule viral sensitizers

The current challenge in cell therapies lies in the inefficient delivery of genes to target cells, resulting in costly manufacturing processes. This project aims to identify and validate small molecule viral sensitizers (VSEs) that enhance the efficiency of cell therapy production. These VSEs will streamline the manufacturing process, making cell therapies more accessible and cost-effective. […]

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Co-designing a physical activity behavior change toolkit to promote effective rheumatoid arthritis self-management

In rheumatoid arthritis care, patients face long waits and frequent appointments. Using a patient-initiated follow-up model can help patients avoid unnecessary appointments and reduce wait times, but this only works if patients have enough support to manage their disease. Physical activity is essential for managing RA, but many people with RA do not have enough […]

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Using Multiomics To Understand Spatial Heterogeneity in Alzheimer’s Disease

Single-cell -Omics analysis methods are having a transformational impact on research in the life sciences. Specifically, the capacity to assess genomes, transcriptomes, or proteomes of individual cells in place of (or in addition to) measuring the average signals from populations of cells allows researchers to ask and answer questions that have never been accessible until […]

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