Canine leptospirosis is a climate-sensitive, bacterial, infectious disease of global importance. Despite being vaccine-preventable, leptospirosis is an important cause of morbidity and mortality in dogs. Across North America and the United Kingdom (UK), the prevalence of canine leptospirosis ranges between 4.8-14%, with evidence for increasing prevalence over time. Leptospirosis can be difficult or slow to […]

Sports related concussion is becoming a major short- and long-term public health concern. The proposed project is designed to test the capabilities of different helmet liner materials in mitigating impact forces resulting from blows to the head, and determine the utility of such materials in reducing the incidence and effects of such concussive blows in […]

NorthMiRs is developing nanotechnology-enabled gene therapies for the treatment of sepsis. We have determined microRNAs that are dysregulated in septic patients and packaged them into a stable, synthetic, and scalable lipid nanoparticle delivery vehicle. Our lead therapeutic, NM-001, a miRNA replacement therapy for sepsis-associated cardiomyopathy has been shown to be anti-inflammatory, anti-microbial and protects organs […]

Heat illness is a spectrum of disorders due to environmental exposure to heat. There is a growing need to combat worker heat exposure in mines, as a function of increasing mine depth. Vale’s Thermal Management Program is designed to protect workers from the hazards of hot conditions, but in dynamic work environments, and among workers […]

“RemoteCare” is a novel initiative that empowers individuals to conduct part of their medical assessments independently via a user-friendly remote digital solution. By enabling self-assessments, it reduces physician workload, minimizes wait times, and ensures quicker access to medical assistance, especially in underserved areas. However, its progress hinges on gaining the trust of traditional healthcare providers, […]

The heart beats 3-4 billion times in one’s lifetime, while adapting its activity to meet the body’s continuously changing physiological demands. This adaptation is driven partly by the central nervous system, which sends signals to a network of nerves in the heart, known as the intracardiac nervous system (IcNS). Many believe the IcNS acts as […]

Access to appropriate mental health services is critically limited for many people living in low and middle-income countries. Making services for depression available in primary health care increases the successful diagnosis and treatment of depression and improves the quality of people’s lives. As the first point of contact with patients, primary care workers are essential […]

Interstitial cystitis is a life-long condition that causes pain and pressure in the bladder. It is not clear how this condition is caused; however, we know that it involves increased bladder inflammation. Currently available treatments for interstitial cystitis do not work for everyone and often stop working after a few years. We are developing a […]

The high attrition rates in clinical drug development and more especially in the late-stages drug clinical development is among the major challenges facing the pharmaceutical industry since failures in late-stage of clinical development are the costliest. The multitude of risks inherent in clinical drug development makes Go/No- Go decisions even more complex for pharmaceutical portfolio […]

Our proposed research project aims to answer the overall question: how do new arthritis medications taken during pregnancy affect mothers and their children? Many types of arthritis strike in females during their childbearing years. Even though we now know more about the effects of arthritis drugs when taken during pregnancy, the picture is not yet […]

Over the years, edible mushrooms have gained increasing recognition for their nutritional value and the potent medicinal properties they offer. Bioactive compounds found in mushrooms, particularly phenolic compounds, exhibit valuable qualities such as anti-proliferative and antioxidant properties. Surprisingly, until now, there has been no investigation into the potential antioxidant effectiveness of Chaga mushrooms of different […]

In this study, patients with idiopathic scoliosis followed at SickKids will undergo topographic analysis using the Momentum Health scanning application in addition to standard of care clinical evaluation and x-rays. The study period is 1 routine clinic visit followed by 3 months after. Patients will self-scan 1x/month at home for the following 3 months. The […]