To date, gut microbiome populations have been associated only with not beneficial choline metabolism, like those related to trimethylamine N-oxide formation. But in this research, it is hypothesized that other mechanisms must be involved in the fates of free choline released from dietary sources. To explore these microbial communities associated to beneficial choline metabolism rendering […]

This fellowship will develop next generation Cell Pouch™ technology, through testing novel animal study (anti-cell death agents, insulin-producing mouse stem cells and islet health (metabolic engraftment efficiency) in parallel to a safety and efficacy (Phase I/II) clinical study of the Cell Pouch™ in Type 1 diabetic in which an in vitro measure of islet health […]

Approximately 40% of COVID-19 survivors experience the Post-Acute Sequelae of COVID-19 (LONG-COVID-19) or Long COVID. It is currently not possible to predict who will become long-haulers and continue to experience symptoms that last for weeks or even months. The goal of this project is to better understand the molecular underpinnings of diverse patient outcomes in […]

Current therapies to manage pain either result in side effects or are insufficient and the associated medical costs and loss of work days come pose a tremendous socioeconomic burden. We recently showed that T-type channel activity is aberrantly regulated in inflammatory and neuropathic pain by the deubiquitinase USP5, and we have begun to explore this […]

The proposed research project involves a partnership between the City, Grenfell Campus (Memorial University of Newfoundland and Labrador) and the Atlantic Forest Center (Natural Resource Canada, Corner Brook office) to generate capacity to collect, summarize, and analyze current tree distribution in the City (and boundary areas) using a combination of remote sensing platforms.

Salt marshes are important coastal ecosystems that provide many services. Due to their high soil fertility, they have a long history of being converted to farmland. There is now growing interest in restoring salt marshes to protect against coastal erosion, mitigate sea level rise, and provide increased habitat for fish, birds, etc. Ducks Unlimited Canada […]

Suu?aa (Chinook salmon) and mi?aat (sockeye salmon) populations have been in decline due to climate change and other human-caused impacts. However, managing these populations and associated fishing activities is often complicated by a lack of information. This purpose of this project is to gather more information on suu?aa and mi?aat populations in the Ha’uukmin (Kennedy) […]

Les conditions climatiques et géographiques et les particularités socio-économiques de la population ont fait du Canada un pays propice au développement d’une flore fongique sécrétrice de toxines naturelles, les mycotoxines. Ces mycotoxines s’avèrent de puissants contaminants de l’environnement et particulièrement de la chaîne alimentaire. A l’heure actuelle, la situation est davantage aggravée par la multi-contamination […]

Physical inactivity is associated with impaired removal of sugar from the blood after a meal, or insulin-resistance and a reduced muscle mass and fitness. While exercise is well-established to prevent these impairments, it may not be feasible in some clinical conditions. Therefore, passive interventions that mimick the stressors and elicit the benefits of exercise may […]

Our intention is to find excellent resistance sources in the Canadian canola cultivars, and other available genotypes through field, greenhouse and lab research to enhance resistance. This will supplement the new resistance sources including novel R gene and quantitative resistance in canola against blackleg disease in Canada. It will also reduce it to become endemic […]

Distillery stillage is a liquid waste produced during the fermentation of milk permeate to yield alcohol. Stillage is an environmental liability due to its potential to create anoxic dead zones in aquatic ecosystems. Nevertheless, stillage also is rich in vital nutrients that can support plant growth. The goal of the proposed research is to reformulate […]

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD). Although its prevalence is rapidly rising worldwide, the pathophysiology and definite treatment of IBD is yet unknown. In particular, Canada is among countries with the highest IBD prevalence. Recently, circadian rhythm disruption has received significant interest for the IBD pathophysiology. In addition IBD patients […]