Detargeting Protein-Protein Interactions For Cellular Design Applications, Using 3D Structure-Based Deep Learning Models

Rational protein design has had a tremendous impact on pharmaceutical, agriculture, and chemical industries over the past 30 years, by focusing exclusively on individual proteins and their intrinsic activities. The next generation of protein design tasks will seek to modify function inside living cells, competing and interacting directly with pre-existing cellular machinery. Modifying systems in […]

Read More
Comparative genomic analysis of Bradyrhizobium strains with natural variability: efficiency and competitiveness implications

A major challenge facing farmers is obtaining the nitrogen needed to support plant growth. Inoculation of legume crops with rhizobia, which supply plants with the required nitrogen, is a green alternative to environmentally hazardous nitrogen-fertilizers. However, rhizobia vary in their effectiveness, and the success of inoculants depends on their ability to outcompete native and poorly-effective […]

Read More
Characterization of thermophilic ?-Mannanase of Thermomyces lanuginosus for production of health promoting prebiotics from agro-waste products.

This research proposal deals with characterization of thermophilic ?-Mannanase of Thermomyces lanuginosus and using this enzyme for hydrolysis of natural mannan to produce prebiotic MOS (Mannooligosaccharides). Alternative routes for the utilization of agricultural by-products are of interest because the economic value of these by-products as animal feed compounds is decreasing. MOS are non-digestible sugar oligomers […]

Read More
Microbial Biocontrol agents as source of Plant Biostimulants

Plant biostimulants are substance(s) and/or micro-organisms whose function when applied to plants or the rhizosphere is to stimulate natural processes to enhance/benefit nutrient uptake, nutrient efficiency, tolerance to abiotic stresses, and crop quality (EBIC). A number of bacterial and fungal biocontrol agents that are used for the management of plant diseases and insect pest are […]

Read More
Applications of Wearable Data and AI to Augment the i-Share Platform

i-Share is a project being conducted by the Université de Bordeaux. It is one of the largest mental health studies in the world, with the goal of collecting self-report information on mental health (e.g., stress, sleep, physical exercise, depression) from over 20,000 students from French universities. Currently, students have access to personal devices, such as […]

Read More
Caractérisation fonctionnelle et valorisation des peptides de défense des arbres de la famille des Salicacées

L’agriculture moderne recherche des solutions pour diminuer l’utilisation de pesticides chimiques. Dans ce contexte, les acteurs de la recherche et de l’innovation ont un rôle à jouer pour développer des pesticides non-chimiques : les biopesticides. Le projet s’inscrit dans ce contexte, en caractérisant une famille de peptides antimicrobiens (appelés RISPs – Rust Induced Secreted Protein) […]

Read More
Gold Nanoparticle based Biosensor to detect viral RNA in vitro by colorimetry

The proposed project involves COVID-19 detection using solution of gold nanoparticles. Upon detection, the gold solution changes its color from red to blue. The solution contains gold nanoparticles with biomolecules that can detect SARS-Cov-2 virus genome that causes COVID-19. The first step is to take saliva sample from the patient and put it inside the […]

Read More
Développement de chambre expérimentale pour exposition sonore de bivalves marins

L’objectif principal est le développement d’un système permettant de mesurer l’impact de sons anthropiques sur des bivalves adultes durant des expositions à long terme. Ainsi le système devra permettre un apport en eau neuve en continue afin d’alimenter en nourriture et en oxygène les animaux sans générer de bruits ambiant. Le système sera testé sur […]

Read More
Drug Release and Antimicrobial Activity of Cannabinoids and Silver from Solvent-Cast Polyvinyl Alcohol (PVA) Films In Vitro

This research project will determine the specific combination of two naturally-occurring anti-infective agents that gives the strongest antibiotic effect against a multi-drug-resistant bacteria called methicillin-resistant Staphylococcus aureus, known as MRSA. As MRSA is a leading cause of skin infection, the anti-infective agents will be incorporated into a specialized wound care film, designed to heal wounds […]

Read More
Soil microbial community in cropping systems integrated with Urochloa spp

Nitrogen (N) is essential in agriculture, but has caused environmental pollution problems, demanding improvements in N use efficiency by crops. Tropical grasses like Urochloa spp. conserve N by biological nitrification inhibition (BNI) and mitigate N losses in soils. However, little is known regarding the effects of BNI plants on soil microbial diversity and functions, especially […]

Read More
Business Intern – DECAP

This project intends to prepare DECAP’s minimum viable product (MVP) and ancillary designs for market-readiness, including building out a manufacturing and logistics pipeline, beginning the process of regulatory approval, and assist DECAP team members in completing a beta-test of our products in-the-field, in a COVID-19-safe manner. The expected project benefits are understanding the market, approaching […]

Read More