Intestinal autoinflammation

Inflammatory bowel disease (IBD), encompassing Crohn’s Disease and ulcerative colitis, is characterized by chronic, relapsing, or progressive inflammation of the intestine. Canada has among the highest incidences and prevalence of IBD in the world with as many as 1 in 160 people with disease [1]. In ulcerative colitis, inflammation predominantly occurs in the epithelial cell […]

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Implication of Epigenetic Dysregulation in Early Embryo Development

The project aims to identify the interdependence that exist between epigenetic modifications that regulate gene expression, as well as their susceptibilities to permanent disruption following errors in the embryonic program. We use an innovative embryonic stem cell model in which the expression of an epigenetic enzyme responsible for DNA methylation can be controlled. We will […]

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Effets secondaires associés à la mobilisation vertébrale dans la population pédiatrique préscolaire : une étude longitudinale de cohorte

De plus en plus de parents consultent en médecine complémentaire et alternative (MCA) pour leurs enfants. Les thérapies manuelles, incluant la manipulation et la mobilisation vertébrale, occupent une place importante au sein des MCA et les chiropraticiens sont les professionnels de la santé utilisant le plus ces thérapies. À ce jour, l’efficacité et la sécurité […]

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3D foot motion Kinetyx Sensor Validation

For this project, the intern will be assessing the ability of the Kinetyx Inertial Measurement Unit (IMU) to measure 3-dimensional foot orientation and running gait metrics in real time. Measurements will be collected both in and outside of the laboratory setting, in order to establish measurement validity for a variety practical applications. The insole imbedded […]

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Aptamer and aptazyme-based multiplexed luminex assay

Aptamers are sequences of DNA or RNA allowing a specific binding of a certain molecule. The use of aptamers instead of antibodies in different applications makes it less time consuming and cost-effective because of the easy production of nucleic acids and their rapid binding to their target. In this project, we suggest using color-coded magnetic […]

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Allele specific re-establishment of imprinted DNA methylation using epigenome editing

Through unknown mechanisms, parent-of-origin-specific methylation marks on one allele of imprinted genes are able to escape the embryonic reprogramming wave occurring during the first week of development and retain their profiles via DNA methylation maintenance activity. Failing to maintain proper genomic imprinting patterns during the embryonic reprogramming leads to various abnormal developmental delay. What remains […]

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Effects of sedation with dexmedetomidine-butorphanol and general anesthesia (propofol-isoflurane) on the Feline Grimace Scale scores

The Feline Grimace Scale is a validated tool that uses changes in facial expressions for acute pain assessment in cats. The tool is a valid, reliable, sensitive and specific for feline acute pain recognition for various types of painful conditions (www.felinegrimacescale.com). The aim of this research project is to assess the effects of sedation and […]

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Exploring the effectiveness of a pilot parasport coach mentorship program.

Informal learning involves acquiring knowledge outside of a structured setting in which learning is self-directed and developed from experience, exposure, and interactions with their environments (Nelson et al., 2006). Examples of informal coach learning includes experience as an athlete, coach observation, self-reflection, reading books, exploring the internet, and learning from experts or mentors in the […]

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Comparison of biological effects of Ceylon cinnamon water Extract and metformin

The use of cinnamon as a flavoring agent and a remedy for metabolic, respiratory, and gynecological disorders is widespread throughout the world. Studies suggest that Ceylon cinnamon may be useful in the treatment of type 2 diabetes. This project will use a high-throughput method to analyze how a concentrated water extract of Ceylon cinnamon changes […]

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Novel Liposomal Formulation of OCZ103

Oncozyme is looking to improve its lead oncology product candidate OCZ103 by incorporating it in nanometer-scale lipid particles known as liposomes. Liposomes have already demonstrated their usefulness in transporting anti-cancer drugs and improving the efficacy and safety aspects of drugs. Liposomal formulation development requires a highly skilled individual both technically and theoretically. The intern who […]

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Apport de la physiothérapie sur la douleur chronique et sur les limitations fonctionnelles, chez la clientèle de 65 ans et plus vivant en centre d’hébergement et de soins de longue durée (CHSLD)

La douleur chronique impacte négativement la mobilité fonctionnelle (se lever, se retourner, etc.) et est, entre autres, classée comme un déterminant de morbidité et un prédicteur de mortalité chez les aînés. La physiothérapie a l’expertise pour la gestion de la douleur et la prévention des incapacités physiques. Or, les soins de physiothérapie ne font pas […]

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