Histone deacetylase 6 (HDAC6) is a protein known to be involved in a wide array of cancers. Although there are currently 4 approved HDAC inhibitors to date, these drugs lack the selectivity to only target HDAC6, given its high structural similarities with 10 other HDAC proteins, resulting in severe side-effects in patients such as nausea, […]

Heme is a naturally occurring molecule found in our blood and as well as in animals, responsible for carrying oxygen throughout our body. Interestingly, heme has been commercially used in various products such as in cosmetics, nutraceuticals, and food. The traditional production of heme however often involves animal slaughter and harsh chemical processing, which is […]

Biological manufacturers are now to make chemicals and biological products (like proteins) by growing large amounts of microorganisms like bacteria or algae. One major quality control step in the manufacturing process is to check the genetic sequences of these microorganisms because they often not correctly made. This is due to the biological method for manipulating […]

Our method reveals the interaction landscape of a given drug. We will generate a two-part biosensor inside living cells. The first part involves a genetically encoded reactive ‘beacon’. The second part is the drug of interest, synthetically modified with complementary reactivity to the beacon. When present together in cells, both parts chemically combine to form […]

The COVID-19 pandemic has increased depression and anxiety in Canada, adding to the current opioid drug dependency crisis. Mental health supports can be used with drug options to relieve symptoms and promote better health. Some cases of depression are resistant to treatment, and alternatives are needed that bring patients relief. Psilocybin is a compound found […]

The Canadian healthcare system is not yet prepared to access and leverage IoT (Internet of Things) data to support clinical decision making outside of hospital settings (Nguyen et al., 2017). With advances in low-cost IoT technology, it is now possible to meaningfully incorporate a variety of sensors into our homes and communities, leading to the […]

The bank swallow is a species of insectivorous songbird considered to be threatened in Canada and has been prioritized for conservation action. All swallow species in Canada are migratory, and in their annual cycle, the post-breeding to first migration period is considered to be a difficult and dangerous time for juvenile birds. We propose to […]

The “Assessing forest harvesting impacts on furbearer habitat at the scale of Indigenous traplines – A case study in Indigenous consultation and forest conservation” project is planned to enhance the understanding of Indigenous rights holders concerning forest management activities that impact the distribution of forest types and ages upon which the forest dwelling wildlife that […]

Plants including Cannabis host distinct beneficial microbial communities on and inside their tissues designated the plant microbiota from the moment that they are planted into the soil as seed. Understanding the microbial partnerships with Cannabis has the potential to affect agricultural practices by improving plant fitness and production yield of Cannabinoids. Much less is known […]

Le but de ce projet est de développer des modèles précis du mouvement des membres supérieurs en utilisant des modèles précis de la biomécanique des membres supérieurs et des algorithmes de machine learning. Ces modèles seront utilisés afin de mettre en place des protocoles expérimentaux permettant de mieux comprendre la manière avec laquelle le système […]

Convalescent plasma–used for over a century as the first treatment option in outbreaks caused by novel pathogens. The therapy involves transfusion of blood plasma from recovered donors, which contains antibodies, that can prevent or treat infection in recipients. Convalescent plasa therapy has been observed empirically or in small studies to confer passive immunity to susceptible […]

There’s nothing quite as delightful as using a well-designed product, especially a piece of software. A field of research known as User eXperience (UX) tries to define measures that describe what a good design feels like. While conventional measures of UX for software work well (how long things take, whether you complete your task successfully), […]