Targeting granzyme B with a novel inhibitor for the treatment of radiodermatitis

Radiodermatitis is a group of skin reactions that occur as a result of radiation therapy. It is a significant health challenge as approximately 70% of all cancer patients receive radiation therapy and approximately 95% of them experience radiodermatitis. Patients with radiodermatitis experience redness, itchiness, pain, scaling, and weeping or crusted wounds. Importantly, radiodermatitis can impede […]

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Ecology and Conservation of Grassland Songbirds in the Waterton Park Front Area

The objective of this project is to establish a long-term study on the ecology of grassland songbirds in the Waterton Park Front Area (just outside of Waterton National Park), Alberta. The student will examine how different grazing regimes and other management actions influence birds. Fieldwork, which will occur from approximately May to July each year, […]

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Developing a machine learning-based diagnostic strategy to detect early onset of double negative prostate cancer by integrating SEMA3C-associated genomic variations and blood biopsies

The main goal of this research project is to study if a protein named SEMA3C can be a biomarker for early detection of an aggressive and lethal form of prostate cancer, named Double Negative Prostate Cancer (DNPC). To test if SEMA3C is a contributing factor in the progression of DNPC, we will compare SEMA3C level […]

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Synchrotron Imaging of Ovaries Ex Situ

Conventional ultrasonography is limited in its ability to image small structures within the ovaries (eg. the eggs and surrounding cells, small fluid filled sacs that contain the eggs known as ‘early antral follicles’, the structure of the ovulation glands). Preliminary data obtained from our research team at the Canadian Light Source (CLS) have indicated that […]

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Calcium Supplements, Elemental Bioavailability, and Uptake by Bone (Part 2)

There is an increasing number and variety of calcium supplements being made available to the Canadian public, often making claims regarding improved action over competitor products. The purpose of this project is to evaluate the effects of drugs and nutraceuticals upon bone health, particularly if they contain elements (such as calcium) which incorporate into newly […]

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Technology Innovations to Improve Patient Outcomes After Spinal Cord Injury

Spinal cord injury (SCI) results in severe paralysis, for which there are no effective treatments. Advanced technologies, however, can play an important role in assisting in the diagnosis, monitoring, and treatment of SCI patients who suffer many impairments beyond the loss of voluntary muscle control. In this proposal, we will develop and apply innovative technologies […]

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Using long-term monitoring data to quantify the impact of white-tailed deer reduction on vegetation and avian communities at Long Point, Ontario

Through analysis of vegetation data collected between 1991 and 2021 in Long Point National Wildlife Area, it is the goal of the research to identify trends and changes in sand dune vegetation communities following a reduction of white-tailed deer browsing pressure. By evaluating the rate and level of change in vegetation diversity, structure, and composition, […]

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Empreintre écologique du son associé au trafic maritime sur les bivalves marins

L’objectif principal est d’évaluer les impacts acoustiques sur la dynamique naturelle des bivalves sur deux sites contrastés, l’un perturbé et l’autre vierge dans la région de Saint-Pierre et Miquelon carcatérisée par la présence unique de large ondes interne générant des variations de température importantes et régulière en moins de 24 heures. Dans un premier temps, […]

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Threats to urban-forest sustainability in Halifax Regional Municipality

Our research aims to provide reliable information to HRM’s urban forestry staff for decision-making to enhance the sustainability of the city’s tree population. One student will investigate the factors that contribute to poor health and mortality of new street trees, aiming to assist the urban forestry staff to alleviate these factors in future plantings. Another […]

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Building sustainable midwifery associations: Application of an evidence-informed framework for midwifery professional association strengthening

There is a severe shortage of midwives in Canada and globally. As a result, there is a large unmet need for sexual and reproductive healthcare in communities. Midwifery associations are an example of largely women led civil society organizations that play a critical role in improving the profession and supporting sexual and reproductive health and […]

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Human-Based Study to Characterize the Biomechanical, Physiological and Comfort Impact of Alternative Torso-Borne Loads and Load Distributions

Torso-borne protective clothing and load carrying equipment (ie. bulletproof vests) is fundamental to the safety of Canadian Armed Forces personnel. To make informed decisions on purchasing and developing new equipment, a suite of mannequin-based tools was developed by Defense Research and Development Canada. They are developing a female model to reflect the Canadian Armed Forces’ […]

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Population-based recurrence probability map to define the microscopic clinical target volume for salvage radiotherapy after prostatectomy (PORTRAy)

Radiotherapy is an effective method to prevent recurrence of disease after the prostate is surgically removed as part of the cancer treatment process. However, since microscopic disease is not visible by conventional imaging techniques, treatment sites are typically determined based on consensus guidelines. PSMA-PET is a novel imaging modality which is able to detect recurrences […]

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